Plons One:研究确定形成血栓的“罪魁祸首”,新药将问世!

2017-05-25 Heather_z727 来宝网

血小板虽然可以支撑伤口,帮助伤口愈合,但是当血小板凝固形成血栓的时候就会导致心脏病和中风的发生,一些血液稀释剂,如阿司匹林可以减少血栓形成的风险。除了防止初期血栓形成之外,还可以防止伤口失血过多。




【科学家找到抗血栓药物的最好目标】血小板虽然可以支撑伤口,帮助伤口愈合,但是当血小板凝固形成血栓的时候就会导致心脏病和中风的发生,一些血液稀释剂,如阿司匹林可以减少血栓形成的风险。除了防止初期血栓形成之外,还可以防止伤口失血过多。

来自托马斯·杰斐逊大学的研究人员已经发现了再血栓形成中,起着至关重要作用的分子,为研制全新的血液稀释药物带来新思路。

完整的研究报告发表于《国家公共图书馆》杂志中。在血栓研究领域,既要做到阻止血栓的形成,又不能影响血小板正常的功能。当出现伤口时,血小板就会迅速被激活,它们一个又一个的连接起来形成血小板栓,血小板不断变化形状,把红细胞包围起来,继而为了帮助伤口愈合,血小板栓会齐心协力,拉近伤口的两端。血块收缩的过程也会使其他游浮的血栓球集中起来。

在先前的研究中,科学家已经确定如果没有CIB1蛋白质就不会形成血栓。为了研究这种可能性,研究人员进行了一系列的试验,试验结果证明,CIB1是抗血栓药物的最好目标,研究人员表示:“如果我们可以阻隔CIB1,那就可以在不阻碍血小板正常功能的情况下,阻隔血栓的形成。而且,进一步来说,可以很大程度上预防心脏病和中风的发生。

原始出处:

Meghna U. Naik, Tejal U. Naik, Ross Summer, et al. Binding of CIB1 to the αIIb tail of αIIbβ3 is required for FAK recruitment and activation in platelets. PLOS ONE (2017). DOI: 10.1371/journal.pone.0176602.

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    2017-05-26 日月生辉

    好方法希望药物不贵!

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=202685, encodeId=8c722026851d, content=好方法希望药物不贵!, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib260FNcic8ThYQJjaU2fLIb1yNqibkbdJs7gVIDr9xJyYeiapArSMjn3W61bPJtpIazSdAxRaFEOKYgfQjX4achN2d/0, createdBy=68472058812, createdName=日月生辉, createdTime=Fri May 26 07:28:02 CST 2017, time=2017-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=202572, encodeId=d70d2025e2eb, content=CIB1是抗血栓药物的最好目标,研究人员表示:“如果我们可以阻隔CIB1,那就可以在不阻碍血小板正常功能的情况下,阻隔血栓的形成。而且,进一步来说,可以很大程度上预防心脏病和中风的发生。”, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151226/IMG567EB873985DE3928.jpg, createdBy=ea941622301, createdName=inter158, createdTime=Fri May 26 00:08:20 CST 2017, time=2017-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=202550, encodeId=3fdb202550d4, content=学习而期待着。, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1ee71931136, createdName=旺哥, createdTime=Thu May 25 22:47:49 CST 2017, time=2017-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=202476, encodeId=e5342024e6fd, content=介绍时能不能详细一点?, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87df1446011, createdName=waxibin, createdTime=Thu May 25 17:59:51 CST 2017, time=2017-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=202426, encodeId=8f0920242694, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Thu May 25 13:44:27 CST 2017, time=2017-05-25, status=1, ipAttribution=)]
    2017-05-26 inter158

    CIB1是抗血栓药物的最好目标,研究人员表示:“如果我们可以阻隔CIB1,那就可以在不阻碍血小板正常功能的情况下,阻隔血栓的形成。而且,进一步来说,可以很大程度上预防心脏病和中风的发生。”

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=202685, encodeId=8c722026851d, content=好方法希望药物不贵!, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib260FNcic8ThYQJjaU2fLIb1yNqibkbdJs7gVIDr9xJyYeiapArSMjn3W61bPJtpIazSdAxRaFEOKYgfQjX4achN2d/0, createdBy=68472058812, createdName=日月生辉, createdTime=Fri May 26 07:28:02 CST 2017, time=2017-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=202572, encodeId=d70d2025e2eb, content=CIB1是抗血栓药物的最好目标,研究人员表示:“如果我们可以阻隔CIB1,那就可以在不阻碍血小板正常功能的情况下,阻隔血栓的形成。而且,进一步来说,可以很大程度上预防心脏病和中风的发生。”, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151226/IMG567EB873985DE3928.jpg, createdBy=ea941622301, createdName=inter158, createdTime=Fri May 26 00:08:20 CST 2017, time=2017-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=202550, encodeId=3fdb202550d4, content=学习而期待着。, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1ee71931136, createdName=旺哥, createdTime=Thu May 25 22:47:49 CST 2017, time=2017-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=202476, encodeId=e5342024e6fd, content=介绍时能不能详细一点?, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87df1446011, createdName=waxibin, createdTime=Thu May 25 17:59:51 CST 2017, time=2017-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=202426, encodeId=8f0920242694, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Thu May 25 13:44:27 CST 2017, time=2017-05-25, status=1, ipAttribution=)]
    2017-05-25 旺哥

    学习而期待着。

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=202685, encodeId=8c722026851d, content=好方法希望药物不贵!, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib260FNcic8ThYQJjaU2fLIb1yNqibkbdJs7gVIDr9xJyYeiapArSMjn3W61bPJtpIazSdAxRaFEOKYgfQjX4achN2d/0, createdBy=68472058812, createdName=日月生辉, createdTime=Fri May 26 07:28:02 CST 2017, time=2017-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=202572, encodeId=d70d2025e2eb, content=CIB1是抗血栓药物的最好目标,研究人员表示:“如果我们可以阻隔CIB1,那就可以在不阻碍血小板正常功能的情况下,阻隔血栓的形成。而且,进一步来说,可以很大程度上预防心脏病和中风的发生。”, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151226/IMG567EB873985DE3928.jpg, createdBy=ea941622301, createdName=inter158, createdTime=Fri May 26 00:08:20 CST 2017, time=2017-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=202550, encodeId=3fdb202550d4, content=学习而期待着。, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1ee71931136, createdName=旺哥, createdTime=Thu May 25 22:47:49 CST 2017, time=2017-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=202476, encodeId=e5342024e6fd, content=介绍时能不能详细一点?, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87df1446011, createdName=waxibin, createdTime=Thu May 25 17:59:51 CST 2017, time=2017-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=202426, encodeId=8f0920242694, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Thu May 25 13:44:27 CST 2017, time=2017-05-25, status=1, ipAttribution=)]
    2017-05-25 waxibin

    介绍时能不能详细一点?

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=202685, encodeId=8c722026851d, content=好方法希望药物不贵!, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib260FNcic8ThYQJjaU2fLIb1yNqibkbdJs7gVIDr9xJyYeiapArSMjn3W61bPJtpIazSdAxRaFEOKYgfQjX4achN2d/0, createdBy=68472058812, createdName=日月生辉, createdTime=Fri May 26 07:28:02 CST 2017, time=2017-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=202572, encodeId=d70d2025e2eb, content=CIB1是抗血栓药物的最好目标,研究人员表示:“如果我们可以阻隔CIB1,那就可以在不阻碍血小板正常功能的情况下,阻隔血栓的形成。而且,进一步来说,可以很大程度上预防心脏病和中风的发生。”, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151226/IMG567EB873985DE3928.jpg, createdBy=ea941622301, createdName=inter158, createdTime=Fri May 26 00:08:20 CST 2017, time=2017-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=202550, encodeId=3fdb202550d4, content=学习而期待着。, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1ee71931136, createdName=旺哥, createdTime=Thu May 25 22:47:49 CST 2017, time=2017-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=202476, encodeId=e5342024e6fd, content=介绍时能不能详细一点?, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87df1446011, createdName=waxibin, createdTime=Thu May 25 17:59:51 CST 2017, time=2017-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=202426, encodeId=8f0920242694, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Thu May 25 13:44:27 CST 2017, time=2017-05-25, status=1, ipAttribution=)]
    2017-05-25 半夏微凉

    学习了谢谢分享

    0

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