Diabetes Care:开滦研究发文称,预测心脏风险不能只看单点血糖,还要看血糖变化趋势

2017-09-29 文韬 中国循环杂志

根据空腹血糖范围与变化模式,研究者识别了5种空腹血糖轨迹:升高-稳定型、升高-降低型、中等-升高型、中等-稳定型和低等-稳定型。

根据空腹血糖范围与变化模式,研究者识别了5种空腹血糖轨迹:升高-稳定型、升高-降低型、中等-升高型、中等-稳定型和低等-稳定型。

校正混杂因素后,与空腹血糖轨迹为中等-稳定型(范围为4.9~5.1 mmol/l)者相比,升高-稳定型(范围为6.1~6.3 mmol/l)者发生心肌梗死的风险升高53%。

而升高-降低型(从6 mmol/l降至5.4 mmol/l)者的心肌梗死风险则降低39%。

与之一致的是,研究期间的空腹血糖累计平均值和增加率能够预测未来心肌梗死风险,而非单次测量的基线空腹血糖水平。

研究者认为,空腹血糖的长期轨迹可能是心肌梗死甚至其他大血管病变风险的重要预测因素。

这是一项前瞻性队列研究,纳入近7万2010年之前没有糖尿病、心肌梗死、卒中和癌症的让人,分别在2006、2008和2010年测量了这些人的空腹血糖水平,并识别了变化轨迹。中位随访3.9年期间,共新发283例心肌梗死。

原始出处:
Cheng Jin, Shuohua Chen, Anand Vaidya,et al.Longitudinal Change in Fasting Blood Glucose and Myocardial Infarction Risk in a Population Without Diabetes,Diabetes Care 2017 Sep; dc170610. https://doi.org/10.2337/dc17-0610

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    2017-09-29 lovetcm

    开滦研究成果会越来越多

    0

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