Am J Kidney Dis:IgA肾病患者妊娠及肾脏结局如何?

2017-03-21 xing.T MedSci原创

由此可见,妊娠会加速IgAN以及CKD 3期女性肾脏疾病的进展速度,但不会加快CKD 1或2期患者肾脏疾病的进展速度。

IgA肾病(IgAN)的妊娠结局是有争议的。近日,肾脏病领域权威杂志Am J Kidney Dis上发表了一篇研究文章。该队列研究评估了妊娠对IgAN患者肾脏疾病的进展和不良妊娠结局危险因素的影响。

该研究的参与者为育龄IgAN妇女,在2003年12月至2014年9月期间至少随访一年。研究人员将妊娠作为一个随时间变化的变量;测定了基础(活检时间)估计的肾小球滤过率(eGFR)、蛋白尿、血压和肾脏病理等指标。研究结局为肾脏疾病进展事件,其被定义为eGFR下降30%或终末期肾脏疾病;eGFR下降率;不良妊娠结局,包括重度子痫前期和流产。

在413例招募的患者中,慢性肾脏病(CKD)1、2、3和4期的患者分别有266名(64.4%)、101名(24.5%)、40名(9.6%)和6名(1.5%)。在随访期间,104名参与者共有116次妊娠,其中110次妊娠持续超过20周,309例患者没有怀孕。调整年龄、EGFR、平均动脉压、尿蛋白和活检时病理组织类型后,研究人员发现在CKD3期到4期的患者,而不是CKD1期到2期患者,随后的妊娠与更快的eGFR下降(-7.44 vs. -3.90ml/min/1.73m2每年;P=0.007)和增加的肾脏进展事件发生率(风险比为5.14;95%可信区间为1.16-22.74)有关,相比于没有怀孕的患者。

由此可见,妊娠会加速IgAN以及CKD 3期女性肾脏疾病的进展速度,但不会加快CKD 1或2期患者肾脏疾病的进展速度。

原始出处:

Xiaole Su, et al. Pregnancy and Kidney Outcomes in Patients With IgA Nephropathy: A Cohort Study. Am J Kidney Dis.2017. http://dx.doi.org/10.1053/j.ajkd.2017.01.043

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    2017-03-23 yibei
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    2017-03-23 gwc389
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    2017-03-22 朱朱*^_^*

    学习了

    0

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    2017-03-21 knowheart

    妊娠会加速IgAN以及CKD 3期女性肾脏疾病的进展速度,但不会加快CKD 1或2期患者肾脏疾病的进展速度

    0

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JASN:IgAN患者通常会有更好的预后

  2012年9月6号,西班牙研究人员发现肾功能正常且无血尿、蛋白尿的IgAN患者长期预后效果理想,该研究结果在线发表于《美国肾脏学会杂志》上(J Am Soc Nephrol. 2012 Sep 6.)。     按照惯例,肾脏病医生将对高水平蛋白尿(尿蛋白,1-2 g/d)患者进行肾活检。西班牙已有8家医院为轻度异常患者采用肾活检,因此Eduardo Gutiérrez博士和他的