Hypertension:尿酸是高血压前期发展为高血压的风险标记!

2017-12-05 xing.T MedSci原创

由此可见,增加血清尿酸是高血压前期发展为高血压的较强风险标记。需要进一步的研究来明确高血压前期者针对高尿酸血症进行治疗是否可以阻止高血压发生。

高血压前期经常进展为高血压,该疾病与心血管疾病和卒中的高发病率和死亡率相关。然而,研究人员对从高血压前期发展为高血压的危险因素仍然知之甚少。

近日,心血管权威杂志Hypertension上发表了一篇研究文章,研究人员使用3584例在2004年发现及2009年复查的高血压前期成年患者(52.1±11岁,2081名男性)的数据进行了一项回顾性队列研究。在对年龄、性别、体重指数、吸烟和饮酒习惯、基线收缩压、舒张压、脉率、糖尿病、血脂异常、慢性肾脏疾病、血尿酸水平进行调整后,研究人员计算了过去的5年间高血压的累计发病率、研究的风险因素,并计算了发生高血压的比值比(OR)。额外的分析评估了血清尿酸(高尿酸血症)是否是发展为高血压的独立危险因素。

研究人员发现高血压前期到高血压的5年累积发生率为25.3%。女性和男性之间没有显著差异(24.4% vs. 26%,P=0.28)。高尿酸血症患者高血压的累积发病率(n=726)明显高于无高尿酸血症者(n=2858,30.7% vs. 24%,P<0.001)。在多变量调整后,从高血压前期发展为高血压的危险因素有:年龄(比值比(OR)为1.023;P<0.001),女性(OR为1.595;P<0.001),较大的体重指数(OR为1.051;P<0.001),较高的基线收缩压(OR为1.072;P<0.001)和舒张血压(OR为1.085;P<0.001),以及较高的血尿酸(OR为1.149;P<0.001)。

由此可见,增加血清尿酸是高血压前期发展为高血压的较强风险标记。需要进一步的研究来明确高血压前期者针对高尿酸血症进行治疗是否可以阻止高血压发生。

原始出处:

Masanari Kuwabara,et al. Uric Acid Is a Strong Risk Marker for Developing Hypertension From Prehypertension A 5-Year Japanese Cohort Study.Hypertension.2017. https://doi.org/10.1161/HYPERTENSIONAHA.117.10370

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    2017-12-16 feather89
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    2017-12-05 戒馋,懒,贪

    谢谢分享学习了

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