NATURE:减肥新思路,吃货福音有多远?

2017-06-05 MedSci MedSci原创

绝经与骨质流失和内脏肥胖有关。之前报道靶向垂体激素促卵泡激素(Fsh)的β亚单位的多克隆抗体可增加小鼠的骨量。近日,国际杂志《NATURE》上在线发表一项关于抑制垂体的促囊泡生成素可以减少小鼠肥胖的发生的研究。

绝经与骨质流失和内脏肥胖有关。之前报道靶向垂体激素促卵泡激素(Fsh)的β亚单位的多克隆抗体可增加小鼠的骨量。近日,国际杂志《NATURE》上在线发表一项关于抑制垂体的促囊泡生成素可以减少小鼠肥胖的发生的研究。

更年期与骨质疏松和腹部脂肪的积累有关。 此前,Mone Zaidi及其同事表明,抗垂体激素Fsh的抗体增加了小鼠的骨量。 在本研究中,他们表明,该抗体还可以降低已经去除卵巢的小鼠中的脂肪组织,或者在高脂肪饮食中减少小鼠的脂肪组织。 抗肥胖效应伴随着UCP1表达的增加和激活棕色脂肪组织并增强产热,增加了全身氧气消耗率及身体活动。

研究表明,只需抑制垂体的促囊泡生成素,即便对小鼠进行高脂肪喂食,仍可减少肥胖的发生。这些发现可以为肥胖和骨质疏松的综合治疗开辟新机会。

原始出处:

Peng Liu, Yaoting Ji,Tony Yuen.et al.Blocking FSH induces thermogenic adipose tissue and reduces body fat.2017

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    2017-12-14 liye789132251
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    2018-05-12 晓辰
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    2017-06-07 cqykthl

    抑制垂体肯定会有很大的副作用啊

    0

  4. 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objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2SEXGDldsNfP4rKvY7vJmaHcyvLXicuyaCTJtVOkX3jvd6DwNMD88hDjJwsU7MnUH6zeqC4zt3yGV/0, createdBy=4e701628585, createdName=flyingzyx, createdTime=Tue Jun 06 09:07:34 CST 2017, time=2017-06-06, status=1, ipAttribution=)]
    2017-06-07 往日如昨

    学习了谢谢分享

    0

  5. 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objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2SEXGDldsNfP4rKvY7vJmaHcyvLXicuyaCTJtVOkX3jvd6DwNMD88hDjJwsU7MnUH6zeqC4zt3yGV/0, createdBy=4e701628585, createdName=flyingzyx, createdTime=Tue Jun 06 09:07:34 CST 2017, time=2017-06-06, status=1, ipAttribution=)]
    2017-06-07 七九九八

    减肥减肥

    0

  6. 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objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2SEXGDldsNfP4rKvY7vJmaHcyvLXicuyaCTJtVOkX3jvd6DwNMD88hDjJwsU7MnUH6zeqC4zt3yGV/0, createdBy=4e701628585, createdName=flyingzyx, createdTime=Tue Jun 06 09:07:34 CST 2017, time=2017-06-06, status=1, ipAttribution=)]
    2017-06-06 Y—xianghai

    学习了新知识

    0

  7. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLPeNmuNF9ibgMfMOAs7Iic5MpiaU8RLmRH67xCKuk5wzfhb7G4ib7ia6z9lrnsTicj1nAUfEOMecZDtvvu/0, createdBy=d7f91939785, createdName=186****0580(小山羊), createdTime=Tue Jun 06 09:40:33 CST 2017, time=2017-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=207219, encodeId=dd5c20e2199a, content=新知识,新理念,, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220317/1c3b2db4747d42e88e5018b394979434/be0fcebf07344e9ab886c37c502e2f29.jpg, createdBy=6bb22051299, createdName=微笑人参, createdTime=Tue Jun 06 09:12:06 CST 2017, time=2017-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=207218, encodeId=227220e218cf, content=很受启发,谢谢。, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2SEXGDldsNfP4rKvY7vJmaHcyvLXicuyaCTJtVOkX3jvd6DwNMD88hDjJwsU7MnUH6zeqC4zt3yGV/0, createdBy=4e701628585, createdName=flyingzyx, createdTime=Tue Jun 06 09:07:34 CST 2017, time=2017-06-06, status=1, ipAttribution=)]
    2017-06-06 ylzr123

    认真学习,不断进步,把经验分享给同好。点赞了!

    0

  8. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLPeNmuNF9ibgMfMOAs7Iic5MpiaU8RLmRH67xCKuk5wzfhb7G4ib7ia6z9lrnsTicj1nAUfEOMecZDtvvu/0, createdBy=d7f91939785, createdName=186****0580(小山羊), createdTime=Tue Jun 06 09:40:33 CST 2017, time=2017-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=207219, encodeId=dd5c20e2199a, content=新知识,新理念,, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220317/1c3b2db4747d42e88e5018b394979434/be0fcebf07344e9ab886c37c502e2f29.jpg, createdBy=6bb22051299, createdName=微笑人参, createdTime=Tue Jun 06 09:12:06 CST 2017, time=2017-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=207218, encodeId=227220e218cf, content=很受启发,谢谢。, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2SEXGDldsNfP4rKvY7vJmaHcyvLXicuyaCTJtVOkX3jvd6DwNMD88hDjJwsU7MnUH6zeqC4zt3yGV/0, createdBy=4e701628585, createdName=flyingzyx, createdTime=Tue Jun 06 09:07:34 CST 2017, time=2017-06-06, status=1, ipAttribution=)]
    2017-06-06 186****0580(小山羊)

    学习了谢谢了。

    0

  9. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLPeNmuNF9ibgMfMOAs7Iic5MpiaU8RLmRH67xCKuk5wzfhb7G4ib7ia6z9lrnsTicj1nAUfEOMecZDtvvu/0, createdBy=d7f91939785, createdName=186****0580(小山羊), createdTime=Tue Jun 06 09:40:33 CST 2017, time=2017-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=207219, encodeId=dd5c20e2199a, content=新知识,新理念,, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220317/1c3b2db4747d42e88e5018b394979434/be0fcebf07344e9ab886c37c502e2f29.jpg, createdBy=6bb22051299, createdName=微笑人参, createdTime=Tue Jun 06 09:12:06 CST 2017, time=2017-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=207218, encodeId=227220e218cf, content=很受启发,谢谢。, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2SEXGDldsNfP4rKvY7vJmaHcyvLXicuyaCTJtVOkX3jvd6DwNMD88hDjJwsU7MnUH6zeqC4zt3yGV/0, createdBy=4e701628585, createdName=flyingzyx, createdTime=Tue Jun 06 09:07:34 CST 2017, time=2017-06-06, status=1, ipAttribution=)]
    2017-06-06 微笑人参

    新知识,新理念,

    0

  10. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLPeNmuNF9ibgMfMOAs7Iic5MpiaU8RLmRH67xCKuk5wzfhb7G4ib7ia6z9lrnsTicj1nAUfEOMecZDtvvu/0, createdBy=d7f91939785, createdName=186****0580(小山羊), createdTime=Tue Jun 06 09:40:33 CST 2017, time=2017-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=207219, encodeId=dd5c20e2199a, content=新知识,新理念,, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220317/1c3b2db4747d42e88e5018b394979434/be0fcebf07344e9ab886c37c502e2f29.jpg, createdBy=6bb22051299, createdName=微笑人参, createdTime=Tue Jun 06 09:12:06 CST 2017, time=2017-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=207218, encodeId=227220e218cf, content=很受启发,谢谢。, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2SEXGDldsNfP4rKvY7vJmaHcyvLXicuyaCTJtVOkX3jvd6DwNMD88hDjJwsU7MnUH6zeqC4zt3yGV/0, createdBy=4e701628585, createdName=flyingzyx, createdTime=Tue Jun 06 09:07:34 CST 2017, time=2017-06-06, status=1, ipAttribution=)]
    2017-06-06 flyingzyx

    很受启发,谢谢。

    0

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