CIRC J:血清维生素D与普通日本人群全因死亡及特定原因死亡之间的关系--久山研究

2017-04-26 MedSci MedSci原创

目前很少有研究调查一般亚洲人群血清维生素D水平与死亡率之间的关系。近期来自日本的学者发表研究性论着于circulation journal。研究者检测血清1,25-二羟维生素D(1,25(OH)2D)水平与全因死亡及特定原因死亡之间的关系。研究纳入2002 - 2012年,即平均9.5年随访时间中,3,292例年龄≥40岁的社区住院日本人。随着血清1,25(OH)2D水平降低,全因死亡的多变量调整

目前很少有研究调查一般亚洲人群血清维生素D水平与死亡率之间的关系。

近期来自日本的学者发表研究性论着于circulation journal。研究者检测血清1,25-二羟维生素D(1,25(OH)2D)水平与全因死亡及特定原因死亡之间的关系。研究纳入2002 - 2012年,即平均9.5年随访时间中,3,292例年龄≥40岁的社区住院日本人。

随着血清1,25(OH)2D水平降低,全因死亡的多变量调整危险比(HR)显着升高(最低四分位数HR 1.54 [95%置信区间,1.18-2.01],第二四分位数1.31 [0.99-1.73 ],第三四分位数为0.94 [0.70-1.25],最高四分位数为1.00; P <0.001)。观察到心血管和呼吸道感染死亡也有类似的关联(P均为<0.01),而癌症死亡或由于其他原因导致的死亡则没有。在分层分析中,肾小球滤过率(eGFR)<60 mL / min / 1.73 m2的受试者较eGFR≥60mL / min / 1.73 m2 患者相比,低血清1,25(OH)2D水平与呼吸道感染死亡风险之间的关联更强。而与eGFR水平之间的联系存在显着的异质性(异质性P = 0.04)。

研究结果表明,普通日本人群血清1,25(OH)2水平较低是导致全因死亡,特别是心血管和呼吸道感染死亡的潜在危险因素,血清1,25(OH)2D水平大大增加了患有肾功能障碍的受试者呼吸道感染的死亡风险。

原始出处:


Umehara K, Mukai N,  et al. Association Between Serum Vitamin D and All-Cause and Cause-Specific Death in a General Japanese Population - The Hisayama Study. Circ J. 2017 Apr 20.

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    2018-03-08 wshxjq
  2. [GetPortalCommentsPageByObjectIdResponse(id=2070230, encodeId=f45720e02300a, content=<a href='/topic/show?id=1f28592221b' target=_blank style='color:#2F92EE;'>#日本人#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59222, encryptionId=1f28592221b, topicName=日本人)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fd34186, createdName=wshxjq, createdTime=Thu Mar 08 11:01:00 CST 2018, time=2018-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=194486, encodeId=ab1e194486eb, content=学习了,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/101296147/1A51842815047D40BFDAA8D69AA8E519/100, createdBy=fd7f2029163, createdName=绛珠草小姐, createdTime=Sat May 06 09:34:39 CST 2017, time=2017-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=194053, encodeId=eac0194053be, content=文章不错,值得拜读, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Fri May 05 08:34:13 CST 2017, time=2017-05-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1294315, encodeId=b418129431513, content=<a href='/topic/show?id=ca6e592189b' target=_blank style='color:#2F92EE;'>#日本#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59218, encryptionId=ca6e592189b, topicName=日本)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f634250, createdName=chentianping, createdTime=Fri Apr 28 05:01:00 CST 2017, time=2017-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=190854, encodeId=378619085433, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Wed Apr 26 20:20:28 CST 2017, time=2017-04-26, status=1, ipAttribution=)]
    2017-05-06 绛珠草小姐

    学习了,谢谢

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=2070230, encodeId=f45720e02300a, content=<a href='/topic/show?id=1f28592221b' target=_blank style='color:#2F92EE;'>#日本人#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59222, encryptionId=1f28592221b, topicName=日本人)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fd34186, createdName=wshxjq, createdTime=Thu Mar 08 11:01:00 CST 2018, time=2018-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=194486, encodeId=ab1e194486eb, content=学习了,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/101296147/1A51842815047D40BFDAA8D69AA8E519/100, createdBy=fd7f2029163, createdName=绛珠草小姐, createdTime=Sat May 06 09:34:39 CST 2017, time=2017-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=194053, encodeId=eac0194053be, content=文章不错,值得拜读, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Fri May 05 08:34:13 CST 2017, time=2017-05-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1294315, encodeId=b418129431513, content=<a href='/topic/show?id=ca6e592189b' target=_blank style='color:#2F92EE;'>#日本#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59218, encryptionId=ca6e592189b, topicName=日本)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f634250, createdName=chentianping, createdTime=Fri Apr 28 05:01:00 CST 2017, time=2017-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=190854, encodeId=378619085433, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Wed Apr 26 20:20:28 CST 2017, time=2017-04-26, status=1, ipAttribution=)]
    2017-05-05 1e10c84am36(暂无匿称)

    文章不错,值得拜读

    0

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    2017-04-26 1e0f8808m18(暂无匿称)

    学习了

    0

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