Diabetes Care:青年2型糖尿病患者较1型有更高的长期并发症及致死风险

2013-07-29 Diabetes Care dxy

代谢组学T2DM和T1DM患者累积存活率 为了评价青年2型糖尿病(T2DM)患者的长期临床结局和存活率,并将其与具有相似发病年龄的1型糖尿病(T1DM)患者进行比较,来自澳大利亚皇家阿尔弗雷德王子医院糖尿病中心的Constantino等进行了一项研究,研究发现,与T1DM比较,青年T2DM是更致命的糖尿病表型,具有较高的死亡率、更多的糖尿病并发症和不良心血管疾病危险因素。研究结果在线发表于201


代谢组学T2DM和T1DM患者累积存活率

为了评价青年2型糖尿病(T2DM)患者的长期临床结局和存活率,并将其与具有相似发病年龄的1型糖尿病(T1DM)患者进行比较,来自澳大利亚皇家阿尔弗雷德王子医院糖尿病中心的Constantino等进行了一项研究,研究发现,与T1DM比较,青年T2DM是更致命的糖尿病表型,具有较高的死亡率、更多的糖尿病并发症和不良心血管疾病危险因素。研究结果在线发表于2013年7月11日的美国《糖尿病治疗》(Diabetes Care)杂志上。

患者记录来自1986年皇家阿尔弗雷德王子医院建立的糖尿病临床数据库,将病人数据与澳大利亚国家死亡指数匹配,以明确至2011年6月所有受试者的死亡结局。从多个方面对354名发病年龄在15-30岁的T2DM患者(T2DM15-30)和T1DM患者的临床和死亡结局进行比较,然而主要与470名与T2DM患者有相似发病年龄的T1DM受试者(T1DM15-30)比较,这样使得年龄对结局的混杂影响减少到最低程度。

对T2DM和T1DM两组患者的中位观察时间分别为21.4年和23.4年,结果显示,824名患者有71例死亡,死亡率为8.6%。T2DM15-30组死亡率明显增多,死亡风险增高(HR 2.0),出现死亡时病程明显较短,年龄相对较年轻。T2DM15-30组心血管疾病死亡人数较多。T2DM和T1DM组比较,尽管血糖控制情况和病程相当,T2DM15-30组蛋白尿发生率和不良的心血管危险因素较高,甚至出现在糖尿病发病后不久。T2DM15-30组神经病变评分和大血管并发症也升高(P<0.0001)。

研究发现,与T1DM比较,青年T2DM是更致命的糖尿病表型,具有较高的死亡率及更多的糖尿病并发症和不良心血管疾病风险。

Constantino MI, Molyneaux L, Limacher-Gisler F, Al-Saeed A, Luo C, Wu T, Twigg SM, Yue DK, Wong J.Long-Term Complications and Mortality in Young-Onset Diabetes: Type 2 diabetes is more hazardous and lethal than type 1 diabetes.Diabetes Care. 2013 Jul 11. [Epub ahead of print]

PMID:
23846814

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (6)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1901133, encodeId=d4051901133fc, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Sun Sep 29 21:52:00 CST 2013, time=2013-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1759330, encodeId=e6f31e5933006, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Mon Jan 06 16:52:00 CST 2014, time=2014-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1757578, encodeId=0cf81e57578a9, content=<a href='/topic/show?id=84ba49031f9' target=_blank style='color:#2F92EE;'>#并发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49031, encryptionId=84ba49031f9, topicName=并发)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a27e37327108, createdName=丁鹏鹏, createdTime=Wed Oct 30 05:52:00 CST 2013, time=2013-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1636724, encodeId=fc351636e24f4, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sat Nov 23 11:52:00 CST 2013, time=2013-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1383136, encodeId=32d413831366f, content=<a href='/topic/show?id=196a1101f7' target=_blank style='color:#2F92EE;'>#2型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1101, encryptionId=196a1101f7, topicName=2型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Wed Jul 31 04:52:00 CST 2013, time=2013-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1473728, encodeId=5b3914e3728a4, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Wed Jul 31 04:52:00 CST 2013, time=2013-07-31, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1901133, encodeId=d4051901133fc, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Sun Sep 29 21:52:00 CST 2013, time=2013-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1759330, encodeId=e6f31e5933006, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Mon Jan 06 16:52:00 CST 2014, time=2014-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1757578, encodeId=0cf81e57578a9, content=<a href='/topic/show?id=84ba49031f9' target=_blank style='color:#2F92EE;'>#并发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49031, encryptionId=84ba49031f9, topicName=并发)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a27e37327108, createdName=丁鹏鹏, createdTime=Wed Oct 30 05:52:00 CST 2013, time=2013-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1636724, encodeId=fc351636e24f4, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sat Nov 23 11:52:00 CST 2013, time=2013-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1383136, encodeId=32d413831366f, content=<a href='/topic/show?id=196a1101f7' target=_blank style='color:#2F92EE;'>#2型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1101, encryptionId=196a1101f7, topicName=2型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Wed Jul 31 04:52:00 CST 2013, time=2013-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1473728, encodeId=5b3914e3728a4, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Wed Jul 31 04:52:00 CST 2013, time=2013-07-31, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1901133, encodeId=d4051901133fc, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Sun Sep 29 21:52:00 CST 2013, time=2013-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1759330, encodeId=e6f31e5933006, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Mon Jan 06 16:52:00 CST 2014, time=2014-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1757578, encodeId=0cf81e57578a9, content=<a href='/topic/show?id=84ba49031f9' target=_blank style='color:#2F92EE;'>#并发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49031, encryptionId=84ba49031f9, topicName=并发)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a27e37327108, createdName=丁鹏鹏, createdTime=Wed Oct 30 05:52:00 CST 2013, time=2013-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1636724, encodeId=fc351636e24f4, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sat Nov 23 11:52:00 CST 2013, time=2013-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1383136, encodeId=32d413831366f, content=<a href='/topic/show?id=196a1101f7' target=_blank style='color:#2F92EE;'>#2型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1101, encryptionId=196a1101f7, topicName=2型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Wed Jul 31 04:52:00 CST 2013, time=2013-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1473728, encodeId=5b3914e3728a4, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Wed Jul 31 04:52:00 CST 2013, time=2013-07-31, status=1, ipAttribution=)]
    2013-10-30 丁鹏鹏
  4. [GetPortalCommentsPageByObjectIdResponse(id=1901133, encodeId=d4051901133fc, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Sun Sep 29 21:52:00 CST 2013, time=2013-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1759330, encodeId=e6f31e5933006, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Mon Jan 06 16:52:00 CST 2014, time=2014-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1757578, encodeId=0cf81e57578a9, content=<a href='/topic/show?id=84ba49031f9' target=_blank style='color:#2F92EE;'>#并发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49031, encryptionId=84ba49031f9, topicName=并发)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a27e37327108, createdName=丁鹏鹏, createdTime=Wed Oct 30 05:52:00 CST 2013, time=2013-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1636724, encodeId=fc351636e24f4, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sat Nov 23 11:52:00 CST 2013, time=2013-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1383136, encodeId=32d413831366f, content=<a href='/topic/show?id=196a1101f7' target=_blank style='color:#2F92EE;'>#2型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1101, encryptionId=196a1101f7, topicName=2型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Wed Jul 31 04:52:00 CST 2013, time=2013-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1473728, encodeId=5b3914e3728a4, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Wed Jul 31 04:52:00 CST 2013, time=2013-07-31, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1901133, encodeId=d4051901133fc, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Sun Sep 29 21:52:00 CST 2013, time=2013-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1759330, encodeId=e6f31e5933006, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Mon Jan 06 16:52:00 CST 2014, time=2014-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1757578, encodeId=0cf81e57578a9, content=<a href='/topic/show?id=84ba49031f9' target=_blank style='color:#2F92EE;'>#并发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49031, encryptionId=84ba49031f9, topicName=并发)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a27e37327108, createdName=丁鹏鹏, createdTime=Wed Oct 30 05:52:00 CST 2013, time=2013-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1636724, encodeId=fc351636e24f4, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sat Nov 23 11:52:00 CST 2013, time=2013-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1383136, encodeId=32d413831366f, content=<a href='/topic/show?id=196a1101f7' target=_blank style='color:#2F92EE;'>#2型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1101, encryptionId=196a1101f7, topicName=2型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Wed Jul 31 04:52:00 CST 2013, time=2013-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1473728, encodeId=5b3914e3728a4, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Wed Jul 31 04:52:00 CST 2013, time=2013-07-31, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1901133, encodeId=d4051901133fc, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Sun Sep 29 21:52:00 CST 2013, time=2013-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1759330, encodeId=e6f31e5933006, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Mon Jan 06 16:52:00 CST 2014, time=2014-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1757578, encodeId=0cf81e57578a9, content=<a href='/topic/show?id=84ba49031f9' target=_blank style='color:#2F92EE;'>#并发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49031, encryptionId=84ba49031f9, topicName=并发)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a27e37327108, createdName=丁鹏鹏, createdTime=Wed Oct 30 05:52:00 CST 2013, time=2013-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1636724, encodeId=fc351636e24f4, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sat Nov 23 11:52:00 CST 2013, time=2013-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1383136, encodeId=32d413831366f, content=<a href='/topic/show?id=196a1101f7' target=_blank style='color:#2F92EE;'>#2型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1101, encryptionId=196a1101f7, topicName=2型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Wed Jul 31 04:52:00 CST 2013, time=2013-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1473728, encodeId=5b3914e3728a4, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Wed Jul 31 04:52:00 CST 2013, time=2013-07-31, status=1, ipAttribution=)]

相关资讯

Diabetes:通过开启Neu1的表达来抑制糖尿病的发生

II型糖尿病患者的胰岛素耐受性部分是由于机体缺少某种蛋白质所致,而这种特殊蛋白质和糖尿病并无关系,蒙特利尔大学等处的研究者的这项研究发现或可帮助开发有效抑制糖尿病发生的疗法,相关研究刊登于国际杂志Diabetes上。 II型糖尿病占据了全世界糖尿病人群中的90%,影响着250万加拿大人的健康,每年在加拿大因糖尿病相关的花费就高达150亿元;研究者通过研究发现,II型糖尿病患者出现的胰岛素耐受性

AIM:双水杨酯能明显降低II型糖尿病患者的血糖水平(TINSAL-T2D研究)

来自哈佛医学院的研究者通过研究发现,一种用于治疗关节炎的药物双水杨酯(salsalate)可以降低II型糖尿病患者的血糖水平以及改善其血糖控制,这或许就帮助科学家对双水杨酯进行开发以获取有效治疗II型糖尿病的药物。 双水杨酯是一种抗炎性药物,研究者在2010的一项研究中进行了TINSAL-T2D的第一阶段研究(对II型糖尿病患者使用双水杨酯进行靶向研究疗法),主要对108位II型糖尿病患者进行

社区中使用二甲双胍在糖尿病治疗中的应用1例

  糖尿病是目前社区卫生服务中心全科医师主要接触和管理的慢性病之一。只有社区全科医师与患者通力合作,加强血糖监测和控制,才能预防和延缓糖尿病并发症的发生。该文是1位社区全科医师在进行糖尿病患者管理过程中的感悟,让我们一同分享。   病例简介   现病史   患者李某,2011年1月于我院就诊。   患者患有2型糖尿病13年,原服药无规律,现服用二甲双胍500 mg,每日3

Diabetes:TNF-α具有类胰岛素样作用

TNF-α注射对血糖动静脉差异的影响 TNF-α具有广泛的代谢作用。然而,系统性TNF-α治疗产生复杂的激素和代谢效应。为了验证局部、安慰剂对照TNF-α输注是否能直接影响胰岛素抵抗和蛋白质分解。来自丹麦奥胡斯大学的Ermina Bach教授及其团队进行了一项研究,该研究发现TNF-α具有类胰岛素样作用。该研究结果在线发表在2013年7月8日的《糖尿病》(Diabetes)杂志上

以糖尿病为主要表现的血色病1例

  摘要  患者男性43岁,因口干、多饮、多尿4年,双下肢水肿5天,以2型糖尿病、糖尿病肾病入院。根据患者青铜色面容、血清铁及铁蛋白增高、肝脾肿大和肝活检病理所见,诊断为原发性血色病。该病历提示,肝血色病表现为色素沉着、肝脾肿大、肝硬化、糖尿病、心脏病变、关节病变、性功能减退,甚至睾丸萎缩;治疗主要为放血疗法,但贫血及严重低蛋白血症者接受长期铁草酰胺治疗可缓解并获生存期延长

Sciecne:胃分流手术可减少糖尿病相关风险因子

老鼠胃旁路手术前(左)后(右)的 PET/ CT 扫描 那些接受某种特别的胃分流手术的罹患糖尿病的肥胖病人会经历糖尿病相关性风险因子的减少,而在大鼠中的新的研究可以解释其原因--暗示在该过程中会有一种创伤性较小的减轻糖尿病的方法。 最近的研究显示,鲁氏Y形胃分流手术(RYGB)可快速减轻与II型糖尿病有关的高血糖。确实,接受 RYGB 的肥胖的糖尿病患者甚至会在其体重减轻之前常常就可停止服用他