糖尿病

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盘点：Diabetes Care 8月刊重要研究汇总

2017-08-05 MedSci MedSci原创

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【1】TCF7L2基因rs7903146变异可增加肥胖青少年IGT/T2D的发生风险Doi: 10.2337/dc17-0290新的一项研究探讨了TCF7L2 rs7903146的风险等位基因使得肥胖青少年糖耐量受损（IGT）或2型糖尿病（T2DM）发生的机制。结果显示，T等位基因与β细胞应答率减低及IGT有关。风险变异的受试者中，抑制内源性肝葡萄糖生成率较低。表明，TCF7L2基因中rs7903



【1】TCF7L2基因rs7903146变异可增加肥胖青少年IGT/T2D的发生风险

Doi: 10.2337/dc17-0290

新的一项研究探讨了TCF7L2 rs7903146的风险等位基因使得肥胖青少年糖耐量受损（IGT）或2型糖尿病（T2DM）发生的机制。结果显示，T等位基因与β细胞应答率减低及IGT有关。风险变异的受试者中，抑制内源性肝葡萄糖生成率较低。表明，TCF7L2基因中rs7903146变异可通过损伤β细胞功能来增加肥胖青少年IGT/T2D的发生风险，而且肝脏胰岛素敏感性可预测随着时间的推移IGT/T2D的发展。

【2】红肉的烹调方法和2型糖尿病的风险有关

Doi: 10.2337/dc17-0204

不同红肉烹调方法与2型糖尿病（2型糖尿病）的发生也有关系？新的研究证实了这一点。该研究中，研究人员探究了使用不同烹调方法常规摄入红肉（≥2顿每周）后2型糖尿病的发病风险。结果发现红肉摄入总量、高温或明火的红肉烹饪方法，尤其是烧烤和烤肉，可进一步增加定期吃肉者糖尿病的发生风险。 

【3】不同糖尿病状态个体的BMI与全因死亡率分析

Doi: 10.2337/dc16-1458

正常血糖、空腹血糖受损（IFG）、新诊断的糖尿病和已诊断的糖尿病患者BMI与死亡率之间的存在何种关联，各组与最低死亡率相关的BMI范围又是如何？为探究此问题，研究人员对12815006名成年人进行了前瞻性监测。结果显示，无论糖尿病状态、性别、年龄和吸烟史，研究人员观察到了U型相关性，而且在每一个年龄和性别群体中，随着糖尿病恶化，最低死亡率的最佳BMI范围逐渐升高。

【4】1型糖尿病患者严重低血糖的风险

Doi: 10.2337/dc16-2723

在DCCT试验期间严重低血糖发生率按季度报告，而在EDIC试验期间每年报告一次。研究人员对影响严重低血糖发生率的危险因素进行了调查。结果显示，在DCCT研究中，强化糖尿病治疗达到的平均HbA1c为~7%与低血糖发生率增加了三倍相关。严重低血糖的发生率在两个DCCT/EDIC研究治疗组之间随着时间而逐渐平衡，这与糖尿病病程进展和类似的HbA1c水平相关。严重低血糖的存在仍然是1型糖尿病患者的一个挑战。

【5】青少年1型糖尿病患者糖尿病相关健康生活质量的相关因素分析

Doi: 10.2337/dc16-1990

新的一项研究中研究人员描述了患有1型糖尿病（T1DM）的青少年和年轻成年人全球样本的糖尿病特异性健康相关生命质量（D-HRQOL），并确定了与生活质量相关的主要因素。该研究预先设定了3个年龄组：8-12岁、13-18岁，和19-25岁。为了评估D-HRQOL，参与者完成了PedsQL 糖尿病模块3.0，并被采访了家庭因素。研究人员从病例中收集了治疗方案和自我管理行为的细节。结果发现，三个年龄组HbA1c越低，D-HRQOL越好，强调在全球青少年和年轻成人样本中更好的D-HRQOL和最佳血糖控制之间的很强的相关性。三种糖尿病管理行为也与最佳血糖控制有关，这提示它们是提高D-HRQOL以及血糖控制临床干预的可能调节因素。

【6】生物标志物可更好的筛选单基因糖尿病

Doi: 10.2337/dc17-0224

单基因糖尿病，糖尿病的早发形式，常被误诊为1型糖尿病，导致不必要的胰岛素治疗。因此需要一种可以准确筛选单基因糖尿病的方法而无需昂贵的基因诊断。该研究中研究人员使用C肽和胰岛自身抗体来筛选单基因糖尿病。结果表明，生物标志物筛选的方法为单基因糖尿病的确定提供了一种有效、廉价和容易实现的手段，适合所有年轻发病的患者。年龄≤30岁的换种单基因糖尿病最低患病率为3.6%。

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    2017-08-16 ms9608593228839890

    #DIA#

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    2018-03-27 ms5439512287675881

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    2018-03-26 木头人513

    #Diabetes#

    0

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    2017-08-06 执着追梦

    学习，谢谢分享

    0

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    2017-08-06 130****4638

    学习了谢谢分享

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1637984, encodeId=ce59163e98491, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Wed Aug 16 02:09:00 CST 2017, time=2017-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1760162, encodeId=6f761e6016226, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=13, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Tue Mar 27 21:09:00 CST 2018, time=2018-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1901749, encodeId=e2101901e4910, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Mon Mar 26 01:09:00 CST 2018, time=2018-03-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=230582, encodeId=28e9230582ea, content=学习，谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhb9xDeHojCicsdRdyC3XXdGk2ib9yLypZuHN06WeW4HO8WN0GGrgEfvnTX8gsckof05GHOU5OM4Mvx/0, createdBy=9cee1982656, createdName=执着追梦, createdTime=Sun Aug 06 07:15:03 CST 2017, time=2017-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=230568, encodeId=2e8623056811, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Sun Aug 06 07:11:27 CST 2017, time=2017-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=230385, encodeId=b46723038525, content=学习，谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhb9xDeHojCicsdRdyC3XXdGk2ib9yLypZuHN06WeW4HO8WN0GGrgEfvnTX8gsckof05GHOU5OM4Mvx/0, createdBy=9cee1982656, createdName=执着追梦, createdTime=Sat Aug 05 16:29:09 CST 2017, time=2017-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=230384, encodeId=449623038471, content=好好好学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM6DGOvNrRdcib3UmzMgpEQpl0ENSJScphsFtdgfibXX1g1IuEYGCjP23UqCd52TxTpSZibtPiclyusaHicnNXd78alaia19Qy1nAFo18/0, createdBy=50381491660, createdName=zwjnj2, createdTime=Sat Aug 05 16:25:34 CST 2017, time=2017-08-05, status=1, ipAttribution=)]
    2017-08-05 执着追梦

    学习，谢谢分享

    0

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    2017-08-05 zwjnj2

    好好好学习学习学习

    0