SCI REP:孕妇口腔和肠道微生物对胎盘微生物定植的作用!

2017-06-08 xing.T MedSci原创

这些结果表明胎盘微生物组与妊娠女性的口服微生物组具有较高的相似性。口腔和肠道微生物都有助于胎盘微生物的种植,这表明胎盘定植可能具有多种生态来源。

胎盘中独特细菌特征已被报道,这提供了胎儿并不是在无菌环境中进行发育的证据。基于与非妊娠女性口腔中微生物组的相似性,研究人员提出了口腔微生物可能作为胎盘中细菌DNA的来源。近日,Scientific reports 杂志上发表了一篇研究文章,研究人员评估了胎盘微生物的可能来源,并检测了同一孕妇肠道、口腔和胎盘的微生物。

研究人员通过16SrRNA测序的手段检查了37名超重和肥胖孕妇的微生物谱。并对粪便和口腔在胎盘微生物群落建立的贡献进行了评估。研究人员确定了身体部位和宏基因组预测功能之间的核心种系。

研究人员发现胎盘微生物组与妊娠女性口腔微生物组表现出较高的相似性和系统发育接近。然而,基于组织起源,在较低分类级别和微生物群中的相似性有所降低。核心菌种有:普雷沃氏菌属、链球菌属和维雷龙菌,在所有的机体腔室均有共生。编码色氨酸、脂肪酸代谢和苯甲酸酯降解的通路在胎盘中高度富集。

这些结果表明胎盘微生物组与妊娠女性的口服微生物组具有较高的相似性。口腔和肠道微生物都有助于胎盘微生物的种植,这表明胎盘定植可能具有多种生态来源。

原始出处:


Luisa F. Gomez-Arango,et al. Contributions of the maternal oral and gut microbiome to placental microbial colonization in overweight and obese pregnant women.Scientific reports. 2017. https://www.nature.com/articles/s41598-017-03066-4

本文系梅斯医学(MedSci)原创编译整理,转载需授权!


版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (4)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1824779, encodeId=1e8e1824e798c, content=<a href='/topic/show?id=702a5065860' target=_blank style='color:#2F92EE;'>#微生物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50658, encryptionId=702a5065860, topicName=微生物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Thu Jan 25 09:39:00 CST 2018, time=2018-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1406832, encodeId=7b2a140683268, content=<a href='/topic/show?id=2aca8365e2c' target=_blank style='color:#2F92EE;'>#胎盘#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83657, encryptionId=2aca8365e2c, topicName=胎盘)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTItxfbnwF4Yku2j227me6wl2EGarBoTicR3tHxrMtib5tnyyEEsgxlHkk8JAS4ZjHsEF7PxhBwh1QwQ/132, createdBy=c8162575557, createdName=liuyong2981, createdTime=Sat Jun 10 00:39:00 CST 2017, time=2017-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208285, encodeId=7c5c20828550, content=这应该是母胎医学的基石, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Thu Jun 08 22:08:36 CST 2017, time=2017-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208120, encodeId=9f1220812066, content=注意口腔菌群, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDcohE5MKT1FYlH69x7qib45icLgBDMANxIh0DDaZibQ2wQL6WianQKpDacEu0ibD5KC4r1PLl1uUcZlaQ/0, createdBy=a7ea2070227, createdName=158****8818, createdTime=Thu Jun 08 09:52:16 CST 2017, time=2017-06-08, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1824779, encodeId=1e8e1824e798c, content=<a href='/topic/show?id=702a5065860' target=_blank style='color:#2F92EE;'>#微生物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50658, encryptionId=702a5065860, topicName=微生物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Thu Jan 25 09:39:00 CST 2018, time=2018-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1406832, encodeId=7b2a140683268, content=<a href='/topic/show?id=2aca8365e2c' target=_blank style='color:#2F92EE;'>#胎盘#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83657, encryptionId=2aca8365e2c, topicName=胎盘)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTItxfbnwF4Yku2j227me6wl2EGarBoTicR3tHxrMtib5tnyyEEsgxlHkk8JAS4ZjHsEF7PxhBwh1QwQ/132, createdBy=c8162575557, createdName=liuyong2981, createdTime=Sat Jun 10 00:39:00 CST 2017, time=2017-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208285, encodeId=7c5c20828550, content=这应该是母胎医学的基石, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Thu Jun 08 22:08:36 CST 2017, time=2017-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208120, encodeId=9f1220812066, content=注意口腔菌群, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDcohE5MKT1FYlH69x7qib45icLgBDMANxIh0DDaZibQ2wQL6WianQKpDacEu0ibD5KC4r1PLl1uUcZlaQ/0, createdBy=a7ea2070227, createdName=158****8818, createdTime=Thu Jun 08 09:52:16 CST 2017, time=2017-06-08, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1824779, encodeId=1e8e1824e798c, content=<a href='/topic/show?id=702a5065860' target=_blank style='color:#2F92EE;'>#微生物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50658, encryptionId=702a5065860, topicName=微生物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Thu Jan 25 09:39:00 CST 2018, time=2018-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1406832, encodeId=7b2a140683268, content=<a href='/topic/show?id=2aca8365e2c' target=_blank style='color:#2F92EE;'>#胎盘#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83657, encryptionId=2aca8365e2c, topicName=胎盘)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTItxfbnwF4Yku2j227me6wl2EGarBoTicR3tHxrMtib5tnyyEEsgxlHkk8JAS4ZjHsEF7PxhBwh1QwQ/132, createdBy=c8162575557, createdName=liuyong2981, createdTime=Sat Jun 10 00:39:00 CST 2017, time=2017-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208285, encodeId=7c5c20828550, content=这应该是母胎医学的基石, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Thu Jun 08 22:08:36 CST 2017, time=2017-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208120, encodeId=9f1220812066, content=注意口腔菌群, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDcohE5MKT1FYlH69x7qib45icLgBDMANxIh0DDaZibQ2wQL6WianQKpDacEu0ibD5KC4r1PLl1uUcZlaQ/0, createdBy=a7ea2070227, createdName=158****8818, createdTime=Thu Jun 08 09:52:16 CST 2017, time=2017-06-08, status=1, ipAttribution=)]
    2017-06-08 lovetcm

    这应该是母胎医学的基石

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1824779, encodeId=1e8e1824e798c, content=<a href='/topic/show?id=702a5065860' target=_blank style='color:#2F92EE;'>#微生物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50658, encryptionId=702a5065860, topicName=微生物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Thu Jan 25 09:39:00 CST 2018, time=2018-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1406832, encodeId=7b2a140683268, content=<a href='/topic/show?id=2aca8365e2c' target=_blank style='color:#2F92EE;'>#胎盘#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83657, encryptionId=2aca8365e2c, topicName=胎盘)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTItxfbnwF4Yku2j227me6wl2EGarBoTicR3tHxrMtib5tnyyEEsgxlHkk8JAS4ZjHsEF7PxhBwh1QwQ/132, createdBy=c8162575557, createdName=liuyong2981, createdTime=Sat Jun 10 00:39:00 CST 2017, time=2017-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208285, encodeId=7c5c20828550, content=这应该是母胎医学的基石, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Thu Jun 08 22:08:36 CST 2017, time=2017-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208120, encodeId=9f1220812066, content=注意口腔菌群, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDcohE5MKT1FYlH69x7qib45icLgBDMANxIh0DDaZibQ2wQL6WianQKpDacEu0ibD5KC4r1PLl1uUcZlaQ/0, createdBy=a7ea2070227, createdName=158****8818, createdTime=Thu Jun 08 09:52:16 CST 2017, time=2017-06-08, status=1, ipAttribution=)]
    2017-06-08 158****8818

    注意口腔菌群

    0

相关资讯

Obstet Gynecol:肝硬化孕妇的临床和产科并发症!

与早期研究相比,尽管孕妇和胎儿死亡率较低,但肝硬化妇女的妊娠仍然与产科不良结局的高风险相关。

宿迁:孕妇产前筛查有补偿

近日,江苏省宿迁市出台孕妇产前筛查补偿政策,强力推进产前筛查这一惠民行动。

J Allergy Clin Immun:维生素D与哮喘

在《过敏和临床免疫学杂志》上发表的一项新研究发现,在怀孕期间服用维生素D补充剂可以积极地改变新生儿的免疫系统,这可以有助于新生儿防止哮喘和呼吸道感染。英国伦敦国王学院的研究人员研究了在怀孕的第二和第三个月每天补充4,400 IU维生素D3对新生儿的影响情况。

J Dent Res:孕期女性吸烟与后代牙齿发育不全之间的联系

到目前为止,我们对牙齿发育不全的环境风险因素所知甚少。这篇研究的目的是为了调查普通环境风险因素与牙齿发育不全之间的联系,例如:怀孕期间女性吸烟、饮酒和咖啡因摄入。

Obstet Gynecol:母亲种族/民族差异对新生儿不良出生结局的影响不同

近期发表在Obstet Gynecol上的一项研究探讨了借助或不借助辅助生殖技术(ART)的单胎生产中,孕妇的种族/民族对早产儿和低出生体重儿(LBW)的影响差异。本研究是一项回顾性队列研究,使用了2000-2010年间美国马萨诸塞州、佛罗里达州居民出生证明数据和国家ART监测系统的数据。有4568822个活产婴儿被纳入研究,其中有64834名借助于ART。研究人员使用χ测试比较了跨种族/民族组产

Cell Metab:准妈妈请放轻松,放轻松,不然以后你的女儿很容易出现暴饮暴食的呢

人们普遍认为,压力会引发饮食失调,如暴饮暴食,而女性比男性更为常见。一度认为两者之间存在的这种联系纯粹是心理上的,但现在,研究人员越来越多地转向用遗传学和生物学原因进行解释。一项最新研究表明,小鼠妊娠后期压力增大可重新激活了大脑诱发其雌性后代表现出暴饮暴食的行为。这项研究还表明,暴饮暴食可通过在青春期改变某些营养素之间的平衡加以预防。