SCI REP:中国人群中肾小球滤过率降低与无症状性颅内动脉狭窄相关!

2017-07-04 xing.T MedSci原创

总之,在中国一般人群中,减少的eGFR,而不是蛋白尿,与无症状的ICAS相关,尤其是60岁以上的受试者中。

慢性肾脏疾病(CKD),它是指由估计的肾小球滤过率(eGFR)降低和/或蛋白尿,其与无症状颅内动脉狭窄(ICAS)之间的相关性在很大程度上是未知的。

近日,Scientific reports 杂志上发表了一篇研究文章,研究人员进行了一项基于人群的横断面研究,该研究招募了5209名没有发生脑卒中、短暂性脑缺血发作和冠心病的参与者。eGFR是采用慢性肾脏病流行病学合作组(CKD-EPI)的计算公式来进行计算获得,并且尿蛋白是通过尿试纸来进行评估。研究人员采用经颅彩色多普勒(TCD)的技术来评估ICAS。

在整个受试者人群中,684名(13.1%)受访者发生了ICAS。在调整了混杂因素后,研究人员发现eGFR<45毫升/分钟/平方米是无症状性ICAS的独立危险因素(比值比[OR]为3.29,95%可信区间[CI]为1.67-6.51),但总的趋势在根据年龄为60岁进行分层的两组之间有所不同(P=0.01)。然而,蛋白尿与无症状性ICAS之间的相关性无统计学意义。

总之,在中国一般人群中,减少的eGFR,而不是蛋白尿,与无症状的ICAS相关,尤其是60岁以上的受试者中。

原始出处:

Zhaoxia Li, et al. Decreased Estimated Glomerular Filtration Rate (eGFR), Not Proteinuria, Is Associated with Asymptomatic Intracranial Arterial Stenosis in Chinese General Population.Scientific reports. 2017. https://www.nature.com/articles/s41598-017-04549-0

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createdTime=Tue Jul 04 22:01:31 CST 2017, time=2017-07-04, status=1, ipAttribution=)]
    2017-07-05 flysky120

    学习一下知识了

    0

  8. 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GetPortalCommentsPageByObjectIdResponse(id=218705, encodeId=308a218e0534, content=酱紫啊,有意思了, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCclExeQ6LOGMD4dTsia4Ty4HtZCxRmG5vO5XIKfKX3a3vusfhHSej4Iib517vmhFW7RQgh7bpDp1yw/0, createdBy=50951609779, createdName=baihao215, createdTime=Wed Jul 05 07:09:11 CST 2017, time=2017-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218589, encodeId=98fb218589c1, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuCl4zaE0zq0kFsKQmg3vef7gFticiaFX50TWZibZibNHbk3YSJ5uSh1a0DcUiaVIHkoe2Om3eYg7oUTlf/0, createdBy=442c2063958, createdName=海棠胜雪, createdTime=Tue Jul 04 22:01:31 CST 2017, time=2017-07-04, status=1, ipAttribution=)]
    2017-07-05 baihao215

    酱紫啊,有意思了

    0

  9. 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GetPortalCommentsPageByObjectIdResponse(id=218705, encodeId=308a218e0534, content=酱紫啊,有意思了, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCclExeQ6LOGMD4dTsia4Ty4HtZCxRmG5vO5XIKfKX3a3vusfhHSej4Iib517vmhFW7RQgh7bpDp1yw/0, createdBy=50951609779, createdName=baihao215, createdTime=Wed Jul 05 07:09:11 CST 2017, time=2017-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218589, encodeId=98fb218589c1, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuCl4zaE0zq0kFsKQmg3vef7gFticiaFX50TWZibZibNHbk3YSJ5uSh1a0DcUiaVIHkoe2Om3eYg7oUTlf/0, createdBy=442c2063958, createdName=海棠胜雪, createdTime=Tue Jul 04 22:01:31 CST 2017, time=2017-07-04, status=1, ipAttribution=)]
    2017-07-04 海棠胜雪

    学习了

    0

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