Circulation:步行速度可预测经导管主动脉瓣置换术后30天的死亡率

2016-03-02 崔倩 译 MedSci原创

手术风险评分不包括脆弱性评估(例如,步速),但这对于严重主动脉瓣狭窄患者考虑经导管主动脉瓣置换术(TAVR)尤其重要。研究人员在接受TAVR(11/2011-06/2014)的8039例患者队列中,这些患者来自于登记在胸外科医师/美国心脏病经导管瓣膜治疗的注册表™协会(STS/ACC TVT注册表),研究人员评估了5米的步行速度与结果的关系。研究人员评估了连续和分类步速和30天的全因死亡率之间的关

手术风险评分不包括脆弱性评估(例如,步速),但这对于严重主动脉瓣狭窄患者考虑经导管主动脉瓣置换术(TAVR)尤其重要。

研究人员在接受TAVR(11/2011-06/2014)的8039例患者队列中,这些患者来自于登记在胸外科医师/美国心脏病经导管瓣膜治疗的注册表™协会(STS/ACC TVT注册表),研究人员评估了5米的步行速度与结果的关系。研究人员评估了连续和分类步速和30天的全因死亡率之间的关联,调整了STS-预测死亡率得分风险和关键变量。次要终点包括住院死亡率、出血、急性肾损伤和卒中。中位数步态速度为0.63米/秒(0.47-0.79),28%为最慢的步行者(0.5米/秒),48%为缓慢步行​​者(0.5至0.83米/秒),而正常的步行者为24%(>0.83米/秒)。速度最慢的,缓慢的,正常的步行者的30天全因死亡率分别为8.4%,6.6%和5.4%(P<0.001)。步行速度每减少0.2米/秒,相对应的30天死亡率增加11%(调整后的比值比为1.11,95%可信区间1.01-1.22)。最慢的步行者比正常步行者的30天死亡率高35%(调整后的比值比为1.35,95%可信区间1.01-1.80),有显著较长的住院时间,并且出院概率较低。

TAVR后的步行速度与30天死亡率独立相关。身体虚弱的患者最慢的速度步态识别有利于预评价手术和手术后更高水平的护理。

原始出处:

Alfredsson J,Stebbins A,Brennan JM,et al.Gait Speed Predicts 30-Day Mortality Following Transcatheter Aortic Valve Replacement,Circulation,2016.2.26

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    2016-05-10 smlt2008
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    2017-01-15 yxch48
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  4. 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createdName=yxch48, createdTime=Sun Jan 15 13:10:00 CST 2017, time=2017-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1646654, encodeId=99f316466546d, content=<a href='/topic/show?id=dc2263294a3' target=_blank style='color:#2F92EE;'>#步行速度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63294, encryptionId=dc2263294a3, topicName=步行速度)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=735f23318189, createdName=shijzhiewnjhch, createdTime=Sat May 21 00:10:00 CST 2016, time=2016-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1654809, encodeId=c669165480994, content=<a href='/topic/show?id=4eb6632899b' target=_blank style='color:#2F92EE;'>#步行#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63289, encryptionId=4eb6632899b, topicName=步行)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6a5524567114, createdName=yuanming15, createdTime=Mon Sep 19 09:10:00 CST 2016, time=2016-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1332386, encodeId=ef90133238650, content=<a href='/topic/show?id=1dd6231822d' target=_blank style='color:#2F92EE;'>#主动脉瓣#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23182, encryptionId=1dd6231822d, topicName=主动脉瓣)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dc4b2500077, createdName=hittouch, createdTime=Fri Mar 04 12:10:00 CST 2016, time=2016-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1367076, encodeId=0f62136e076cb, content=<a href='/topic/show?id=b6222320322' target=_blank style='color:#2F92EE;'>#主动脉瓣置换术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23203, encryptionId=b6222320322, topicName=主动脉瓣置换术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b24249, createdName=medsci246, createdTime=Fri Mar 04 12:10:00 CST 2016, time=2016-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1415033, encodeId=2bc51415033d8, content=<a href='/topic/show?id=04812314540' target=_blank style='color:#2F92EE;'>#主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23145, encryptionId=04812314540, topicName=主动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77603112682, createdName=circumcision, createdTime=Fri Mar 04 12:10:00 CST 2016, time=2016-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1510041, encodeId=77e915100417a, content=<a href='/topic/show?id=e9bce8254ef' target=_blank style='color:#2F92EE;'>#经导管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78254, encryptionId=e9bce8254ef, topicName=经导管)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Fri Mar 04 12:10:00 CST 2016, time=2016-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1536485, encodeId=a299153648598, content=<a href='/topic/show?id=a894e826546' target=_blank style='color:#2F92EE;'>#经导管主动脉瓣置换#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78265, encryptionId=a894e826546, topicName=经导管主动脉瓣置换)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b38112697961, createdName=yytms, createdTime=Fri Mar 04 12:10:00 CST 2016, time=2016-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1576518, encodeId=b9f715e6518d6, content=<a href='/topic/show?id=48fee966468' target=_blank style='color:#2F92EE;'>#置换术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79664, encryptionId=48fee966468, topicName=置换术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Fri Mar 04 12:10:00 CST 2016, time=2016-03-04, status=1, ipAttribution=)]
    2016-09-19 yuanming15
  5. [GetPortalCommentsPageByObjectIdResponse(id=1977759, encodeId=352c19e7759b0, content=<a href='/topic/show?id=93a211600a' target=_blank style='color:#2F92EE;'>#30天#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1160, encryptionId=93a211600a, topicName=30天)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c39f145, createdName=smlt2008, createdTime=Tue May 10 03:10:00 CST 2016, time=2016-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1742353, encodeId=42891e42353d7, content=<a href='/topic/show?id=39cae96626f' target=_blank style='color:#2F92EE;'>#置换#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79662, encryptionId=39cae96626f, topicName=置换)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3a7c35056336, 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encryptionId=4eb6632899b, topicName=步行)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6a5524567114, createdName=yuanming15, createdTime=Mon Sep 19 09:10:00 CST 2016, time=2016-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1332386, encodeId=ef90133238650, content=<a href='/topic/show?id=1dd6231822d' target=_blank style='color:#2F92EE;'>#主动脉瓣#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23182, encryptionId=1dd6231822d, topicName=主动脉瓣)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dc4b2500077, createdName=hittouch, createdTime=Fri Mar 04 12:10:00 CST 2016, time=2016-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1367076, encodeId=0f62136e076cb, content=<a href='/topic/show?id=b6222320322' target=_blank style='color:#2F92EE;'>#主动脉瓣置换术#</a>, beContent=null, 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04 12:10:00 CST 2016, time=2016-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1576518, encodeId=b9f715e6518d6, content=<a href='/topic/show?id=48fee966468' target=_blank style='color:#2F92EE;'>#置换术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79664, encryptionId=48fee966468, topicName=置换术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Fri Mar 04 12:10:00 CST 2016, time=2016-03-04, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1977759, encodeId=352c19e7759b0, content=<a href='/topic/show?id=93a211600a' target=_blank style='color:#2F92EE;'>#30天#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1160, encryptionId=93a211600a, topicName=30天)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c39f145, createdName=smlt2008, createdTime=Tue May 10 03:10:00 CST 2016, time=2016-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1742353, encodeId=42891e42353d7, content=<a href='/topic/show?id=39cae96626f' target=_blank style='color:#2F92EE;'>#置换#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79662, encryptionId=39cae96626f, topicName=置换)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3a7c35056336, 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encryptionId=4eb6632899b, topicName=步行)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6a5524567114, createdName=yuanming15, createdTime=Mon Sep 19 09:10:00 CST 2016, time=2016-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1332386, encodeId=ef90133238650, content=<a href='/topic/show?id=1dd6231822d' target=_blank style='color:#2F92EE;'>#主动脉瓣#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23182, encryptionId=1dd6231822d, topicName=主动脉瓣)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dc4b2500077, createdName=hittouch, createdTime=Fri Mar 04 12:10:00 CST 2016, time=2016-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1367076, encodeId=0f62136e076cb, content=<a href='/topic/show?id=b6222320322' target=_blank style='color:#2F92EE;'>#主动脉瓣置换术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23203, encryptionId=b6222320322, topicName=主动脉瓣置换术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b24249, createdName=medsci246, createdTime=Fri Mar 04 12:10:00 CST 2016, time=2016-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1415033, encodeId=2bc51415033d8, content=<a href='/topic/show?id=04812314540' target=_blank style='color:#2F92EE;'>#主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23145, encryptionId=04812314540, topicName=主动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77603112682, createdName=circumcision, createdTime=Fri Mar 04 12:10:00 CST 2016, time=2016-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1510041, 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04 12:10:00 CST 2016, time=2016-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1576518, encodeId=b9f715e6518d6, content=<a href='/topic/show?id=48fee966468' target=_blank style='color:#2F92EE;'>#置换术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79664, encryptionId=48fee966468, topicName=置换术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Fri Mar 04 12:10:00 CST 2016, time=2016-03-04, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=1977759, encodeId=352c19e7759b0, content=<a href='/topic/show?id=93a211600a' target=_blank style='color:#2F92EE;'>#30天#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1160, encryptionId=93a211600a, topicName=30天)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c39f145, createdName=smlt2008, createdTime=Tue May 10 03:10:00 CST 2016, time=2016-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1742353, encodeId=42891e42353d7, content=<a href='/topic/show?id=39cae96626f' target=_blank style='color:#2F92EE;'>#置换#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79662, encryptionId=39cae96626f, topicName=置换)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3a7c35056336, 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