J Gastroenterology:经腹超声检查评估溃疡性结肠炎的有效性分析

2019-01-06 MedSci MedSci原创

据报道,经腹超声检查(US)是评估溃疡性结肠炎(UC)的有效工具,因此,本项前瞻性多中心研究旨在确定与超声检查用于评估UC的疾病程度和活动的有效性。

背景及目的
据报道,经腹超声检查(US)是评估溃疡性结肠炎(UC)的有效工具,因此,本项前瞻性多中心研究旨在确定与超声检查用于评估UC的疾病程度和活动的有效性。

方法
总共有156例UC患者进行了本项前瞻性研究。所有患者在入院2天内接受了超声检查和结肠镜检查。我们将结肠分为六个部分,并使用超声和结肠镜检查每个节段和直肠。肠壁厚度,分层和溃疡的严重程度按照评分定义为1-4分。根据Matts的内镜分类,结肠镜严重程度也评分为1-4分。使用kappa统计分析所有结肠区段的超声和结肠镜之间的一致性。还使用Spearman相关系数将超声和结肠镜的发现与临床疾病活动指数(CAI)和组织学分级进行了比较。

结果
在所有结肠段中,超声和结肠镜等级之间存在一致性(加权κ  = 0.55,p  <0.001)。超声分级与CAI评分(r  = 0.40,p <0.001)和组织学分级(r  = 0.35,p  <0.001)显着相关。

结论
这项前瞻性多中心研究显示,超声和结肠镜之间在评估UC疾病活动方面具有中等一致性。因此,超声可以更普遍地用于在日常临床实践中评估UC严重程度。

原始出处:

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    2019-12-03 nymo
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    2019-08-08 mjldent
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    2019-11-04 许安
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    2019-01-06 医者仁心5538

    很少用超声检查肠壁病变。

    0

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JCC :溃疡性结肠炎中内镜评分与组织学评分可以通过验证指数很好的关联起来

内镜检查和组织病理评估是评估溃疡性结肠炎疾病活动的关键;但目前尚未有研究将内镜和组织学指标进行相关性分析。本项研究的目标是将溃疡性结肠炎内窥镜严重程度指数[UCEIS]与已建立UC患者的两个新的验证组织学指标进行相关性分析。

DSS: 维持性阿达木单抗浓度可以使炎症性肠病长期处于缓解期

生物制剂疗法正在成为治疗炎症性肠病(IBD)[克罗恩病(CD)和溃疡性结肠炎(UC)]的新标准治疗方法。因此,本项研究旨在探究维持治疗期间血清阿达木单抗浓度与IBD生化,内镜和组织学缓解的关系。

Inflam Bowel Dis:miR-206可以作为溃疡性结肠炎对美沙拉嗪治疗反应的生物标志物

微小RNA(miRNA)是重要的翻译后调节因子。溃疡性结肠炎(UC)中升高的miR-206水平与抗炎性A3腺苷受体(A3AR)表达的抑制相关。然而,miR-206与UC患者组织学缓解的关系目前还不清楚。本研究将miR-206的表达水平与通过长期美沙拉嗪治疗的患者的组织学缓解进行研究分析,以确定该主要药物对UC的可能作用的模式。

Inflam Bowel Dis: Golimumab的连续临床反应与重度溃疡性结肠炎患者病程变化相关

在溃疡性结肠炎(UC)患者中使用golimumab维持治疗时,有约50%的患者接受诱导治疗的持续临床反应(CCR)会持续1年。本项研究旨在探究连续临床反应与golimumab治疗效果的关系。

JCC: AlphaE整合素表达在克罗恩病患者回肠中增加并且不受炎症影响

最近的研究结果表明,αE整合素表达在效应T细胞上会明显富集,并且肠αE+T细胞具有增加的炎性细胞因子的表达。αE整合素表达是对etrolizumab反应的潜在预测生物标志物,etrolizumab是针对β4整合素的单克隆抗体,其靶向α4β7和αEβ7。研究人员在本项研究中评估了健康和炎症性肠病患者中αE+细胞的流行和定位以及总αE基因表达情况。

JCC: 一种预测溃疡性结肠炎患者接受标准治疗无效的生物标志物

先前有研究已证实肠淋巴细胞浸润的糖基化谱的变化可以调节T细胞活性,并且与溃疡性结肠炎[UC]患者的疾病严重程度相关。本项研究旨在探究肠道炎症浸润中支化N-聚糖的异质表达是否可以在疾病早期预测治疗反应。