Alzheimers Dementia:筛选6000文章,新冠后长期认知功能如何改变?

2022-03-26 网络 网络

与健康对照组相比,从COVID-19康复的患者在感染后7个月内的一般认知能力较低。

随着越来越多的人从严重急性呼吸系统综合症冠状病毒2(SARS-CoV-2)感染中恢复过来,迫切需要研究该疾病的中期和长期后果。越来越多的证据表明,一些患者在急性感染阶段后表现出疲劳、"脑雾 "或认知方面的抱怨等症状,通常被称为 "长COVID"。一项为期6个月的研究利用73,435名2019年冠状病毒病(COVID-19)患者的医疗记录中的多维数据表明,在患病的头30天后,个人的死亡风险增加,卫生资源利用率提高,神经认知障碍带来的负担也增加。事实上,以往流行病的证据显示,随后的神经系统,特别是认知方面的并发症会发生,如1918年至1921年的严重流感流行(也称为西班牙流感)。

最近,在2012年中东呼吸综合征冠状病毒(MERS-CoV)爆发期间,报告了脑炎、感觉障碍、昏迷和严重的神经系统损害的案例,在2003年严重急性呼吸综合征冠状病毒(SARS-CoV)爆发期间,报告了大脑和中枢神经系统的血管或炎症损害。

认知功能障碍对功能和生活质量有很大影响。鉴于COVID-19的高发病率和相关的经济、健康和社会负担,研究其发生和潜在机制是至关重要的。

阿根廷Fleni研究所的Lucia Crivelli等人,评估了以前没有认知障碍的成年COVID-19患者的认知障碍发生率是否增加。

在2020年1月1日至2021年12月13日的Medline/Web of Science/Embase中,按照系统回顾和元分析的首选报告项目(PRISMA)指南进行搜索。

并进行了蒙特利尔认知评估(MoCA)总分的荟萃分析,对康复的COVID-19和健康对照组进行了比较。

在6202篇文章中,纳入了27项研究,涉及2049人(平均年龄=56.05岁,评估时间从急性期到感染后7个月不等)。

在COVID-19后的病人中发现了执行功能、注意力和记忆的损害。

对290人的亚组进行了荟萃分析,显示COVID-19后患者与对照组之间的MoCA得分有差异(P=0.0049)。

该研究的重要意义在于发现了:与健康对照组相比,从COVID-19康复的患者在感染后7个月内的一般认知能力较低。



原文出处:
Crivelli L, Palmer K, Calandri I, et al. Changes in cognitive functioning after COVID‐19: A systematic review and meta‐analysis. Alzheimer’s & Dementia. Published online March 17, 2022:alz.12644. doi:10.1002/alz.12644

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    2022-07-14 anminleiryan
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