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Clin Chem：唾液AMY1拷贝数变异调控年龄相关的2型糖尿病风险？

2020-07-17 MedSci原创 MedSci原创

2型糖尿病；风险
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唾液淀粉酶基因（AMY1）中的拷贝数变异（CNV）调节唾液α-淀粉酶水平，并与餐后血糖性状相关。 AMY1-CNV是否在年龄介导的胰岛素抵抗(IR)变化中起作用尚不清楚。

唾液淀粉酶基因（AMY1）中的拷贝数变异（CNV）调节唾液α-淀粉酶水平，并与餐后血糖性状相关。 AMY1-CNV是否在年龄介导的胰岛素抵抗(IR)变化中起作用尚不清楚。

在波士顿波多黎各健康研究(BPRHS, n = 749)和降脂药物和饮食网络研究(GOLDN, n = 980)两项研究中使用双重定量实时聚合酶链反应检测了AMY1-CNV，并在BPRHS中测定了血浆代谢组学特征。根据AMY1基因的高拷贝数或低拷贝数来评估年龄与血糖特性和2型糖尿病(T2D)之间的关系，从而检测AMY1- cnv与年龄之间的相互作用。此外，还研究了代谢物与AMY1-CNV和年龄相互作用对T2D风险的关系。

研究发现在两项研究中，AMY1拷贝数低的受试者的IR与年龄呈正相关。T2D与BPRHS中淀粉1拷贝数低但淀粉1拷贝数高的参与者的年龄相关性不大。代谢途径富集分析发现戊糖代谢途径是基于与IR和AMY1-CNV与年龄相互作用相关的代谢物。此外，在老年参与者中，高淀粉1拷贝数往往与较低水平的核糖酸、红藻酸和阿拉伯酸相关，所有这些都与IR呈正相关。

研究发现的证据支持AMY1-CNV在改变年龄和IR之间的关系中的作用。AMY1拷贝数低的个体随着年龄的增长，其IR也会增加。

原始出处：

Yuwei Liu,  Caren E Smith,Salivary AMY1 Copy Number Variation Modifies Age-Related Type 2 Diabetes Risk

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    2021-05-16 ms3994565386320060

    #2型糖尿病风险#

    0

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    2020-12-03 lily1616

    #年龄相关#

    0

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    2020-11-15 pps20019

    #拷贝数变异#

    0

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    2020-12-31 bsmagic9132

    #拷贝数#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1956329, encodeId=604319563293e, content=<a href='/topic/show?id=a74d1109c8' target=_blank style='color:#2F92EE;'>#2型糖尿病风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1109, encryptionId=a74d1109c8, topicName=2型糖尿病风险)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/4E6244DB7C1860858424437821E08291/100, createdBy=a6a52500039, createdName=ms3994565386320060, createdTime=Sun May 16 13:18:45 CST 2021, time=2021-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1933485, encodeId=f2e6193348542, content=<a href='/topic/show?id=79654901349' target=_blank style='color:#2F92EE;'>#年龄相关#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49013, encryptionId=79654901349, topicName=年龄相关)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8143398, createdName=lily1616, createdTime=Thu Dec 03 01:18:45 CST 2020, time=2020-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2019228, encodeId=5a57201922848, content=<a href='/topic/show?id=19305629924' target=_blank style='color:#2F92EE;'>#拷贝数变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56299, encryptionId=19305629924, topicName=拷贝数变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ae503, createdName=pps20019, createdTime=Sun Nov 15 05:18:45 CST 2020, time=2020-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1983923, encodeId=ed591983923e5, content=<a href='/topic/show?id=3a375629858' target=_blank style='color:#2F92EE;'>#拷贝数#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56298, encryptionId=3a375629858, topicName=拷贝数)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3eaf430, createdName=bsmagic9132, createdTime=Thu Dec 31 12:18:45 CST 2020, time=2020-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1779878, encodeId=c4df1e79878e6, content=<a href='/topic/show?id=937f24663e' target=_blank style='color:#2F92EE;'>#AMY1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2466, encryptionId=937f24663e, topicName=AMY1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e524260, createdName=dinorsor524, createdTime=Sun Sep 27 02:18:45 CST 2020, time=2020-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=803319, encodeId=6063803319fa, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJp0sD8Z3gbQpmzBtwg9CW7YicibuHSzMIfhBANYvGZiaEcH2gk0IrjXgRzR231rEUtXkHIBBbvbe6Zw/132, createdBy=80725261937, createdName=wangzheng00, createdTime=Sun Jul 19 14:55:05 CST 2020, time=2020-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1342710, encodeId=61271342e1065, content=<a href='/topic/show?id=34cb381023e' target=_blank style='color:#2F92EE;'>#变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38102, encryptionId=34cb381023e, topicName=变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=78c32500188, createdName=12498dabm77暂无昵称, createdTime=Sun Jul 19 13:18:45 CST 2020, time=2020-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043220, encodeId=a18d1043220c0, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Sat Jul 18 01:18:45 CST 2020, time=2020-07-18, status=1, ipAttribution=)]
    2020-09-27 dinorsor524

    #AMY1#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1956329, encodeId=604319563293e, content=<a href='/topic/show?id=a74d1109c8' target=_blank style='color:#2F92EE;'>#2型糖尿病风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1109, encryptionId=a74d1109c8, topicName=2型糖尿病风险)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/4E6244DB7C1860858424437821E08291/100, createdBy=a6a52500039, createdName=ms3994565386320060, createdTime=Sun May 16 13:18:45 CST 2021, time=2021-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1933485, encodeId=f2e6193348542, content=<a href='/topic/show?id=79654901349' target=_blank style='color:#2F92EE;'>#年龄相关#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49013, encryptionId=79654901349, topicName=年龄相关)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8143398, createdName=lily1616, createdTime=Thu Dec 03 01:18:45 CST 2020, time=2020-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2019228, encodeId=5a57201922848, content=<a href='/topic/show?id=19305629924' target=_blank style='color:#2F92EE;'>#拷贝数变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56299, encryptionId=19305629924, topicName=拷贝数变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ae503, createdName=pps20019, createdTime=Sun Nov 15 05:18:45 CST 2020, time=2020-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1983923, encodeId=ed591983923e5, content=<a href='/topic/show?id=3a375629858' target=_blank style='color:#2F92EE;'>#拷贝数#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56298, encryptionId=3a375629858, topicName=拷贝数)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3eaf430, createdName=bsmagic9132, createdTime=Thu Dec 31 12:18:45 CST 2020, time=2020-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1779878, encodeId=c4df1e79878e6, content=<a href='/topic/show?id=937f24663e' target=_blank style='color:#2F92EE;'>#AMY1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2466, encryptionId=937f24663e, topicName=AMY1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e524260, createdName=dinorsor524, createdTime=Sun Sep 27 02:18:45 CST 2020, time=2020-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=803319, encodeId=6063803319fa, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJp0sD8Z3gbQpmzBtwg9CW7YicibuHSzMIfhBANYvGZiaEcH2gk0IrjXgRzR231rEUtXkHIBBbvbe6Zw/132, createdBy=80725261937, createdName=wangzheng00, createdTime=Sun Jul 19 14:55:05 CST 2020, time=2020-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1342710, encodeId=61271342e1065, content=<a href='/topic/show?id=34cb381023e' target=_blank style='color:#2F92EE;'>#变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38102, encryptionId=34cb381023e, topicName=变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=78c32500188, createdName=12498dabm77暂无昵称, createdTime=Sun Jul 19 13:18:45 CST 2020, time=2020-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043220, encodeId=a18d1043220c0, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Sat Jul 18 01:18:45 CST 2020, time=2020-07-18, status=1, ipAttribution=)]
    2020-07-19 wangzheng00

    学习

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1956329, encodeId=604319563293e, content=<a href='/topic/show?id=a74d1109c8' target=_blank style='color:#2F92EE;'>#2型糖尿病风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1109, encryptionId=a74d1109c8, topicName=2型糖尿病风险)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/4E6244DB7C1860858424437821E08291/100, createdBy=a6a52500039, createdName=ms3994565386320060, createdTime=Sun May 16 13:18:45 CST 2021, time=2021-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1933485, encodeId=f2e6193348542, content=<a href='/topic/show?id=79654901349' target=_blank style='color:#2F92EE;'>#年龄相关#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49013, encryptionId=79654901349, topicName=年龄相关)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8143398, createdName=lily1616, createdTime=Thu Dec 03 01:18:45 CST 2020, time=2020-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2019228, encodeId=5a57201922848, content=<a href='/topic/show?id=19305629924' target=_blank style='color:#2F92EE;'>#拷贝数变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56299, encryptionId=19305629924, topicName=拷贝数变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ae503, createdName=pps20019, createdTime=Sun Nov 15 05:18:45 CST 2020, time=2020-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1983923, encodeId=ed591983923e5, content=<a href='/topic/show?id=3a375629858' target=_blank style='color:#2F92EE;'>#拷贝数#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56298, encryptionId=3a375629858, topicName=拷贝数)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3eaf430, createdName=bsmagic9132, createdTime=Thu Dec 31 12:18:45 CST 2020, time=2020-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1779878, encodeId=c4df1e79878e6, content=<a href='/topic/show?id=937f24663e' target=_blank style='color:#2F92EE;'>#AMY1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2466, encryptionId=937f24663e, topicName=AMY1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e524260, createdName=dinorsor524, createdTime=Sun Sep 27 02:18:45 CST 2020, time=2020-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=803319, encodeId=6063803319fa, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJp0sD8Z3gbQpmzBtwg9CW7YicibuHSzMIfhBANYvGZiaEcH2gk0IrjXgRzR231rEUtXkHIBBbvbe6Zw/132, createdBy=80725261937, createdName=wangzheng00, createdTime=Sun Jul 19 14:55:05 CST 2020, time=2020-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1342710, encodeId=61271342e1065, content=<a href='/topic/show?id=34cb381023e' target=_blank style='color:#2F92EE;'>#变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38102, encryptionId=34cb381023e, topicName=变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=78c32500188, createdName=12498dabm77暂无昵称, createdTime=Sun Jul 19 13:18:45 CST 2020, time=2020-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043220, encodeId=a18d1043220c0, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Sat Jul 18 01:18:45 CST 2020, time=2020-07-18, status=1, ipAttribution=)]
    2020-07-19 12498dabm77暂无昵称

    #变异#

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1956329, encodeId=604319563293e, content=<a href='/topic/show?id=a74d1109c8' target=_blank style='color:#2F92EE;'>#2型糖尿病风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1109, encryptionId=a74d1109c8, topicName=2型糖尿病风险)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/4E6244DB7C1860858424437821E08291/100, createdBy=a6a52500039, createdName=ms3994565386320060, createdTime=Sun May 16 13:18:45 CST 2021, time=2021-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1933485, encodeId=f2e6193348542, content=<a href='/topic/show?id=79654901349' target=_blank style='color:#2F92EE;'>#年龄相关#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49013, encryptionId=79654901349, topicName=年龄相关)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8143398, createdName=lily1616, createdTime=Thu Dec 03 01:18:45 CST 2020, time=2020-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2019228, encodeId=5a57201922848, content=<a href='/topic/show?id=19305629924' target=_blank style='color:#2F92EE;'>#拷贝数变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56299, encryptionId=19305629924, topicName=拷贝数变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ae503, createdName=pps20019, createdTime=Sun Nov 15 05:18:45 CST 2020, time=2020-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1983923, encodeId=ed591983923e5, content=<a href='/topic/show?id=3a375629858' target=_blank style='color:#2F92EE;'>#拷贝数#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56298, encryptionId=3a375629858, topicName=拷贝数)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3eaf430, createdName=bsmagic9132, createdTime=Thu Dec 31 12:18:45 CST 2020, time=2020-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1779878, encodeId=c4df1e79878e6, content=<a href='/topic/show?id=937f24663e' target=_blank style='color:#2F92EE;'>#AMY1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2466, encryptionId=937f24663e, topicName=AMY1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e524260, createdName=dinorsor524, createdTime=Sun Sep 27 02:18:45 CST 2020, time=2020-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=803319, encodeId=6063803319fa, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJp0sD8Z3gbQpmzBtwg9CW7YicibuHSzMIfhBANYvGZiaEcH2gk0IrjXgRzR231rEUtXkHIBBbvbe6Zw/132, createdBy=80725261937, createdName=wangzheng00, createdTime=Sun Jul 19 14:55:05 CST 2020, time=2020-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1342710, encodeId=61271342e1065, content=<a href='/topic/show?id=34cb381023e' target=_blank style='color:#2F92EE;'>#变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38102, encryptionId=34cb381023e, topicName=变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=78c32500188, createdName=12498dabm77暂无昵称, createdTime=Sun Jul 19 13:18:45 CST 2020, time=2020-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043220, encodeId=a18d1043220c0, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Sat Jul 18 01:18:45 CST 2020, time=2020-07-18, status=1, ipAttribution=)]
    2020-07-18 misszhang

    谢谢MedSci提供最新的资讯

    0