BJC:CDX2对Ⅱ期结肠癌患者预后的影响

2018-11-30 MedSci MedSci原创

BJC近期发表了一篇文章,研究CDX2表达对II期结肠癌患者预后的影响。

BJC近期发表了一篇文章,研究CDX2表达对II期结肠癌患者预后的影响。

研究分析了两个无偏倚的队列,代表了2002年和2003年期间在丹麦接受手术的II期结肠癌的所有患者。利用免疫组化在肿瘤切片上评估CDX2表达情况。根据结果将患者分为三组,CDX2阳性组,CDX2中度组和CDX2阴性组,用于与临床数据进行比较。研究共纳入1157名患者。研究结果表明两个队列中CDX2表达缺失和无病生存不良具有显着关系,p ?= 0.0267和0.0118。第一个队列中,CDX2表达阴性,中度和阳性组的五年无病生存率分别为66%,72%和74%,第二个队列中分别为的62%,65%和75%。两个队列数据组合后进行多重Cox回归分析证实了CDX2对无病生存的独立预后影响。

文章最后认为,该回顾性研究对CDX2对II期结肠癌患者预后的影响进行了验证。结果验证了前瞻性试验的结果。

原始出处:

Torben Frøstrup Hansen, Sanne Kjær-Frifeldt, et al. Prognostic impact of CDX2 in stage II colon cancer: results from two nationwide cohorts. BJC. November 2018 doi: https://doi.org/10.1038/s41416-018-0285-5

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    2019-02-02 wodejia-dayu
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    2018-12-01 1209e435m98(暂无昵称)

    学习了,谢谢分享

    0

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    2018-11-30 王秀

    学习了,涨知识了!

    0

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