Cell Rep:视网膜神经节细胞的突触分布模式

2018-11-27 MedSci MedSci原创

华盛顿大学结构生物系的Yu WQ等人近日在Cell Rep上发表了他们的一项重要工作。在这篇文章中,作者强调了两个视觉环路,即树突状区域的突触后视网膜神经节细胞(RGC)及其轴突区域的突触前双极细胞(BC)在不同区域间的差异。

华盛顿大学结构生物系的Yu WQ等人近日在Cell Rep上发表了他们的一项重要工作。在这篇文章中,作者强调了两个视觉环路,即树突状区域的突触后视网膜神经节细胞(RGC)及其轴突区域的突触前双极细胞(BC)在不同区域间的差异。

调整感觉处理过程可以通过神经元的聚集面积,输入神经类型以及与这些输入神经元的连接比例和数量来衡量。聚集区域通常会随着样本空间的变化会在不同区域之间有较大的差异。

作者研究的两个视觉环路发现,在不同区域间的存在差异。同时指出,尽管存在这种差异,但在两种环路中,在不同的树突状区域的每种BC神经元类型的输入比例却保持恒定。此外,BC和RGC之间的突触密度在不同区域中也是不变的。

他们的结果证明,神经元通过调整突触延伸来确保特定BC类型与其对应的RGC之间在突触数量的一致性。

原文出处:

Yu, W.Q., et al., Synaptic Convergence Patterns onto Retinal Ganglion Cells Are Preserved despite Topographic Variation in Pre- and Postsynaptic Territories. Cell Rep, 2018. 25(8): p. 2017-2026.e3.

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    2018-12-08 维他命
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    2018-11-27 医者仁心5538

    学习了

    0

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