Am J Gastroenterol:地中海饮食、非酒精性脂肪肝与胰岛素抵抗

2017-10-26 zhangfan MedSci原创

研究认为,坚持地中海饮食模式可降低非酒精性脂肪肝患病率,对于NAFLD患者,高地中海饮食依从性可降低胰岛素抵抗

由于生活方式和饮食习惯等因素,西方国家心血管疾病,包括非酒精性脂肪肝(NAFLD)的患病率不断增长。地中海饮食(Med-Diet)是预防血管疾病的有效方法,但与NAFLD的关系尚未考察。

研究招募了584名门诊患者,患者存在有一个或多个心血管危险因素,如II型糖尿病(T2DM)、动脉高血压、超重、肥胖和血脂异常。超声检查提示存在肝脂肪变性。通过膳食问卷调查患者的地中海饮食依从性,分为低、中、高依从性,同时考察胰岛素抵抗情况。

参与者平均年龄56.2±12.4岁,其中女性占38.2%,82.7%的患者存在肝脂肪变性,地中海饮食依从性高的患者和低的患者相比,其病变率分别为71.4%和96.5%。多元逻辑回归分析显示,高甘油三酯(OR:2.913;P=0.002)、log (ALT) (OR:6.186;P<0.001)、地中海饮食的依从性(依从性中等vs低OR:0.115;P=0.041,高vs低OR:0.093;P=0.030), 糖尿病(OR:3.940;P=0.003)以及高腰围(OR:3.012;P<0.001)与 NAFLD相关。食物方面,低肉类摄入(OR: 0.178; P<0.001)可显著降低NAFLD风险。在334名非糖尿病NAFLD患者中,年龄 (OR:1.035,P=0.025)、高腰围(OR:7.855,P<0.001)、高甘油三酯 (OR:2.152,P=0.011)以及Log (ALT) (OR:2.549,P=0.002)与胰岛素抵抗直接相关, 地中海饮食与其呈负相关 (OR:0.801,P=0.018)。

研究认为,坚持地中海饮食模式可降低非酒精性脂肪肝患病率,对于NAFLD患者,高地中海饮食依从性可降低胰岛素抵抗。

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    2018-09-19 baoya
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    2018-08-20 许安
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    2017-10-28 wgx311
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    2017-10-27 雅文博武

    学习了很多先进的技术水平

    0

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