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ARD：高嘌呤食物可增加五倍痛风发作风险

2012-09-16 佚名 网络

高嘌呤食物痛风
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高嘌呤食物与痛风发作的相关性已是众所周知，但究竟两者之间存在怎样的量化关系？为回答这个问题，研究者设计了一项病例交叉设计研究，对633例痛风患者进行了一年的随访，检测了一系列可能导致周期性痛风发作的危险因素。受试者在痛风发作时需回答以下问题：痛风发作开始的时间、临床症状和体征、用药（包括抗痛风药物）及在痛风发作前两天内存在的潜在危险因素（包括每日摄入的不同嘌呤含量的食物种类）。在痛风控制期也有两天

高嘌呤食物与痛风发作的相关性已是众所周知，但究竟两者之间存在怎样的量化关系？为回答这个问题，研究者设计了一项病例交叉设计研究，对633例痛风患者进行了一年的随访，检测了一系列可能导致周期性痛风发作的危险因素。

受试者在痛风发作时需回答以下问题：痛风发作开始的时间、临床症状和体征、用药（包括抗痛风药物）及在痛风发作前两天内存在的潜在危险因素（包括每日摄入的不同嘌呤含量的食物种类）。在痛风控制期也有两天需回答同样的问题。

相对于两日内最低嘌呤摄入量的五分之一，每增加五分之一的嘌呤摄入，周期性痛风发作的几率明显上升。相应地，从动物源食物摄入嘌呤，每增加五分之一，周期性痛风发作的几率也会上升。而在植物源食物，这种上升的趋势不明显。通过性别、酒精摄入或应用利尿剂、别嘌呤醇、NSAIDs及秋水仙碱等药物进行亚组分析校正，研究者认为，在痛风患者中，急性的嘌呤摄入可增加近五倍的急性痛风发作风险。减少或避免摄入嘌呤含量丰富的食物，特别是动物源的食物，有助于降低痛风发作的风险。

链接：Zhang Y Chen C Choi H Chaisson C Hunter D Niu J Neogi T.Purine-rich foods intake and recurrent gout attacks.Ann Rheum Dis 2012 71 9 :1448-53

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    2012-09-18 楚秀娟

    #痛风发作#

    0

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    2012-09-18 yhy100201

    #食物#

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    2012-09-18 爆笑小医

    #高嘌呤#

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