Neurology:术后谵妄患者的脑显微结构变化

2017-08-05 zhangfan MedSci原创

术后谵妄会导致脑结构异常进而导致认知轨迹发生变化

近日研究人员通过MR扩散张量成像考察了术后谵妄对纵向脑显微结构变化的影响。SAGES研究中,年龄超过70岁的,无痴呆患者进行了择期手术。对113名参与者进行了术前以及术后1年的MR扩散张量成像。研究人员统计术后谵妄的严重程度和发生率。研究人员在调整了年龄、性别、血管合并症和基线认知能力后,考察了谵妄严重程度与MR纵向扩散变化的关联。共发生了25起术后谵妄 (22%)。研究发现,术后谵妄的发生与严重程度与脑室周围、额叶和颞叶白质的纵向扩散变化相关。上述扩散变化与1年的认知表现变化相关,但认知变化与谵妄严重程度或发生不相关。研究人员认为,术后谵妄会导致脑结构异常进而导致认知轨迹发生变化。原始出处:Michele Cavallari et al. Longitudinal diffusion changes following postoperative delirium in older people without dementia. Neurology. August 4 2017.本文系梅斯医学(MedSci)原创编译整理,转载需授权!

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    2019-07-01 小微940490

    mark

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    2017-09-28 yinhl1978
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createdName=幸运8355, createdTime=Thu Aug 10 21:17:05 CST 2017, time=2017-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=231711, encodeId=8cfd231e1190, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6lR0HdZibhWZ60R0PbDKxKOKTx2cxC1B8bqCg5WFj3DV4YaTBzJv9RrNyScwZ6wVicroZ2As62f2cIA1SfN8hJAB/0, createdBy=6e241959371, createdName=幸运8355, createdTime=Wed Aug 09 07:58:19 CST 2017, time=2017-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=231538, encodeId=c24e23153803, content=学习了,感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6lR0HdZibhWZ60R0PbDKxKOKTx2cxC1B8bqCg5WFj3DV4YaTBzJv9RrNyScwZ6wVicroZ2As62f2cIA1SfN8hJAB/0, createdBy=6e241959371, createdName=幸运8355, createdTime=Tue Aug 08 15:56:32 CST 2017, time=2017-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=231201, encodeId=ec6023120190, content=学习了,感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6lR0HdZibhWZ60R0PbDKxKOKTx2cxC1B8bqCg5WFj3DV4YaTBzJv9RrNyScwZ6wVicroZ2As62f2cIA1SfN8hJAB/0, createdBy=6e241959371, createdName=幸运8355, createdTime=Mon Aug 07 18:45:40 CST 2017, time=2017-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1307298, encodeId=57f9130e29860, content=<a href='/topic/show?id=2fbb61104e6' target=_blank style='color:#2F92EE;'>#术后谵妄#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61104, encryptionId=2fbb61104e6, topicName=术后谵妄)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5462342, createdName=sunmin0219, createdTime=Sun Aug 06 22:26:00 CST 2017, time=2017-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=230807, encodeId=a58b23080e3b, content=学习了,感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6lR0HdZibhWZ60R0PbDKxKOKTx2cxC1B8bqCg5WFj3DV4YaTBzJv9RrNyScwZ6wVicroZ2As62f2cIA1SfN8hJAB/0, createdBy=6e241959371, createdName=幸运8355, createdTime=Sun Aug 06 20:15:50 CST 2017, time=2017-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=230713, encodeId=ca8d230e13cf, content=术后,难免存在并发症, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/C3426ED027FF661B0C576A5B3127C2E8/40, createdBy=39dc1706090, createdName=QQ25ed180f, createdTime=Sun Aug 06 12:07:57 CST 2017, time=2017-08-06, status=1, ipAttribution=)]
    2017-08-10 幸运8355

    学习了,感谢分享

    0

  5. 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content=术后,难免存在并发症, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/C3426ED027FF661B0C576A5B3127C2E8/40, createdBy=39dc1706090, createdName=QQ25ed180f, createdTime=Sun Aug 06 12:07:57 CST 2017, time=2017-08-06, status=1, ipAttribution=)]
    2017-08-09 幸运8355

    学习了,谢谢分享

    0

  6. 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content=术后,难免存在并发症, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/C3426ED027FF661B0C576A5B3127C2E8/40, createdBy=39dc1706090, createdName=QQ25ed180f, createdTime=Sun Aug 06 12:07:57 CST 2017, time=2017-08-06, status=1, ipAttribution=)]
    2017-08-08 幸运8355

    学习了,感谢分享

    0

  7. 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objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61104, encryptionId=2fbb61104e6, topicName=术后谵妄)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5462342, createdName=sunmin0219, createdTime=Sun Aug 06 22:26:00 CST 2017, time=2017-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=230807, encodeId=a58b23080e3b, content=学习了,感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6lR0HdZibhWZ60R0PbDKxKOKTx2cxC1B8bqCg5WFj3DV4YaTBzJv9RrNyScwZ6wVicroZ2As62f2cIA1SfN8hJAB/0, createdBy=6e241959371, createdName=幸运8355, createdTime=Sun Aug 06 20:15:50 CST 2017, time=2017-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=230713, encodeId=ca8d230e13cf, content=术后,难免存在并发症, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/C3426ED027FF661B0C576A5B3127C2E8/40, createdBy=39dc1706090, createdName=QQ25ed180f, createdTime=Sun Aug 06 12:07:57 CST 2017, time=2017-08-06, status=1, ipAttribution=)]
    2017-08-07 幸运8355

    学习了,感谢分享

    0

  8. 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createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6lR0HdZibhWZ60R0PbDKxKOKTx2cxC1B8bqCg5WFj3DV4YaTBzJv9RrNyScwZ6wVicroZ2As62f2cIA1SfN8hJAB/0, createdBy=6e241959371, createdName=幸运8355, createdTime=Tue Aug 08 15:56:32 CST 2017, time=2017-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=231201, encodeId=ec6023120190, content=学习了,感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6lR0HdZibhWZ60R0PbDKxKOKTx2cxC1B8bqCg5WFj3DV4YaTBzJv9RrNyScwZ6wVicroZ2As62f2cIA1SfN8hJAB/0, createdBy=6e241959371, createdName=幸运8355, createdTime=Mon Aug 07 18:45:40 CST 2017, time=2017-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1307298, encodeId=57f9130e29860, content=<a href='/topic/show?id=2fbb61104e6' target=_blank style='color:#2F92EE;'>#术后谵妄#</a>, beContent=null, 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  9. 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content=术后,难免存在并发症, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/C3426ED027FF661B0C576A5B3127C2E8/40, createdBy=39dc1706090, createdName=QQ25ed180f, createdTime=Sun Aug 06 12:07:57 CST 2017, time=2017-08-06, status=1, ipAttribution=)]
    2017-08-06 幸运8355

    学习了,感谢分享

    0

  10. 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content=术后,难免存在并发症, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/C3426ED027FF661B0C576A5B3127C2E8/40, createdBy=39dc1706090, createdName=QQ25ed180f, createdTime=Sun Aug 06 12:07:57 CST 2017, time=2017-08-06, status=1, ipAttribution=)]
    2017-08-06 QQ25ed180f

    术后,难免存在并发症

    0

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