NEJM:误食防冻剂所致的乙二醇中毒——病例报道

2017-10-14 MedSci MedSci原创

男性患者,80岁,酒精使用障碍史,在家中摔倒昏迷后被送往急诊科。因患者昏迷无法提供任何进一步的历史。血清研究显示,肌酐水平为2.4 mg/dl(212μmol/L;参考范围为0.6-1.3 mg/dl[53-115 μmol/L),碳酸氢盐水平为9 mmol /L(参考范围为21-32),阴离子间隙为26 mmol/L(参考范围为7-16),血清渗透压为357mOsm/kg水(参考范围275-29

男性患者,80岁,酒精使用障碍史,在家中摔倒昏迷后被送往急诊科。

因患者昏迷无法提供任何进一步的历史。血清研究显示,肌酐水平为2.4 mg/dl(212μmol/L;参考范围为0.6-1.3 mg/dl[53-115 μmol/L),碳酸氢盐水平为9 mmol /L(参考范围为21-32),阴离子间隙为26 mmol/L(参考范围为7-16),血清渗透压为357mOsm/kg水(参考范围275-295),渗透压差为49 mOsm /kg水(参考范围<10)。光学显微镜检查尿液沉积物显示,样本中具有两种不同形态特征的草酸钙一水合物晶体:具有尖端的窄矩形(图A)和哑铃形晶体(图B)。在偏振光下,晶体呈正双折射;与光平行时呈蓝色,垂直时为黄色(图C)。



鉴于患者乙二醇中毒的可能性很高,抽取患者血液用于检测乙二醇的水平,并立即开始使用甲吡唑和透析进行治疗。乙二醇中毒最常见于摄入防冻液或除冰溶液后。在抽取血清40小时后患者的乙二醇水平为211 mg/dl(34 mmol/L;参考范围<1 mg/dl [<0.2 mmol/L])。

甲吡唑治疗3天以及5天内4次透析治疗后患者的精神状态和肾功能恢复正常。患者后来自述自己误食了防冻剂。

原始出处:


Mohamad Hanouneh, Teresa K. Chen. Calcium Oxalate Crystals in Ethylene Glycol Toxicity. N Engl J Med 2017; 377:1467October 12, 2017DOI: 10.1056/NEJMicm1704369

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    2018-05-20 weiz
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    2017-10-25 lofter

    学习了感谢分享

    0

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    2017-10-17 1e2332e9m29(暂无匿称)

    食品中毒要处处小心

    0

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    2017-10-16 mashirong
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    2017-10-16 yjs木玉

    好很好.值得我努力学习

    0

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    2017-10-15 戒馋,懒,贪

    谢谢分享.有点意思

    0

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    2017-10-15 惠映实验室

    这个要注意.学习了.谢谢.

    0

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    2017-10-14 131****2916

    不错的文章值得推荐一下

    0