Science Immunology:1型糖尿病病因新解

2018-02-12 药明康德 学术经纬

1型糖尿病患者 (type 1 diabetes, T1D) 的胰岛中存在着很多CD8+ T细胞,这些自身反应性CD8+ T细胞能够杀伤分泌胰岛素的β细胞,从而导致T1D的产生。

1型糖尿病患者 (type 1 diabetes, T1D) 的胰岛中存在着很多CD8+ T细胞,这些自身反应性CD8+ T细胞能够杀伤分泌胰岛素的β细胞,从而导致T1D的产生。法国巴黎科钦研究所 (Cochin Institute) 的研究人员对健康人和T1D患者体内对锌转运蛋白8186-194 抗原和其它胰岛抗原表位 (epitopes) 产生反应的CD8+ T细胞进行了研究。他们发现,在健康人和T1D患者的外周循环中这些T细胞出现的频率相当,而且T细胞的功能也一样。不同的是,在T1D患者中这些CD8+ T细胞会在胰脏富集,并且对共生的类杆菌也产生反应。这些结果表明T1D症状的产生需要外周免疫调控失常和促进炎症发生的胰岛微环境。

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    2018-02-14 jichang
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    2018-02-14 深海的鱼

    学习学习学习

    0

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    2018-02-13 紫迎馨

    学习了

    0

  4. 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createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Tue Feb 13 08:49:42 CST 2018, time=2018-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=287569, encodeId=1ea128e569d5, content=谢谢分享. , beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Tue Feb 13 07:52:58 CST 2018, time=2018-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=287568, encodeId=39cf28e56843, content=继续关注. , beContent=null, objectType=article, channel=null, level=null, likeNumber=52, 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GetPortalCommentsPageByObjectIdResponse(id=287532, encodeId=a55028e53272, content=^_^^_^, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Swp2ehfHpiciczeTntUyQOlIGMzQ705ic67sdMTVMbwTv7KbmlUvxrGvRSvQZjPkz7ib5tEDfIaORgczPtmHDpwojg/0, createdBy=c54b2163125, createdName=wqkm, createdTime=Tue Feb 13 07:05:54 CST 2018, time=2018-02-13, status=1, ipAttribution=)]
    2018-02-13 龙胆草

    学习谢谢分享

    0

  5. 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    2018-02-13 doctorJiangchao

    谢谢分享.

    0

  6. 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    2018-02-13 doctorJiangchao

    继续关注.

    0

  7. 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encodeId=1b6828e556e7, content=学习了分享了, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/21/39b6a0099eb602e8ac1f7e10d5d440a9.jpg, createdBy=dee01724555, createdName=杨利洪, createdTime=Tue Feb 13 07:30:12 CST 2018, time=2018-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=287542, encodeId=57a928e5421b, content=厉害了我的哥不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Tue Feb 13 07:09:02 CST 2018, time=2018-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=287532, encodeId=a55028e53272, content=^_^^_^, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Swp2ehfHpiciczeTntUyQOlIGMzQ705ic67sdMTVMbwTv7KbmlUvxrGvRSvQZjPkz7ib5tEDfIaORgczPtmHDpwojg/0, createdBy=c54b2163125, createdName=wqkm, createdTime=Tue Feb 13 07:05:54 CST 2018, time=2018-02-13, status=1, ipAttribution=)]
    2018-02-13 doctorJiangchao

    继续学习.

    0

  8. 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    2018-02-13 杨利洪

    学习了分享了

    0

  9. 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    2018-02-13 飛歌

    厉害了我的哥不错

    0

  10. 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    2018-02-13 wqkm

    ^_^^_^

    0

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