CHEST:早期胃癌患者发生肺结核的危险因素分析

2015-11-05 崔倩 译 MedSci原创

胃切除术是肺结核的危险因素之一。然而,没有研究报道关于早期胃癌(EGC)患者发展为结核病和胃切除之间的关联。这项研究评估了EGC患者发展为TB相关的传统危险因素,包括胃大部切除术。研究人员利用韩国国家癌症中心胃癌中心的数据库进行了一项回顾性队列研究。T1病变病理EGC患者通过胃切除或内镜下切除证实被列入此研究。总共有1935例患者构成的EGC队列。其中,1495例患者经胃大部分切除术,其余440例

胃切除术是肺结核(TB)的危险因素之一。然而,没有研究报道关于早期胃癌(EGC)患者发生结核病和胃切除之间的关联。这项研究评估了EGC患者发生TB相关的传统危险因素,包括胃大部切除术。

研究人员利用韩国国家癌症中心-胃癌中心的数据库进行了一项回顾性队列研究。T1病变病理EGC患者通过胃切除或内镜下切除被列入此研究。

总共有1935例患者构成的EGC队列。其中,1495例患者经胃大部分切除术,其余440例患者通过内镜切除。中位随访时间为4.9年,在此期间发生31例结核病(结核病发病率,334/10万人年;95%Cl,227-475)。多因素Cox回归分析表明,X线胸片和胃切除术旧的结核病变是显著的危险因素(风险比分别为[HR],5.01;95%Cl,2.44-10.28;P<0.001;HR,8.95;95%Cl,1.22-65.78;P =0.031)。在胃切除术人群中,旧的结核病变、胃大部切除术约1年后重量和白蛋白水平降低≥15%是显著的危险因素(分别为HR,4.80;95%Cl,2.26-10.18;P<0.001;HR,3.08;95 %Cl,1.47-6.48;P=0.003;HR,5.02;95%Cl,1.47-17.12;P =0.010)。

旧肺结核病灶和胃切除术是EGC人群发生肺结核显著的危险因素。此外,在胃切除亚组中,旧结核病灶和≥15%的术后重量和白蛋白水平减少量是显著的危险因素。

原始出处:

Il Ju Choi,Young-Woo Kim,Hee Seok Lee,et al.Risk Factors for TB in Patients With Early Gastric Cancer,CHEST,2015.9.28

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    2016-04-02 Smile2680
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