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Cell：皮肤微生物菌群，高度稳定，又一个健康保护神

2016-05-06 MedSci MedSci原创

皮肤微生物菌群
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虽然皮肤中的免疫细胞能保护机体免受有害生物的侵害，但到现在为止，皮肤中自然存在的数以百万计的共生细菌（统称为皮肤菌群）是否也具有有益作用。NIH研究小组利用小鼠模型观察到共生菌群通过与皮肤的免疫细胞相互作用有助于提高免疫保护。他们的研究结果刊登2012年的Science杂志上。研究者使用人体皮肤共生表皮葡萄球菌种植与无菌小鼠（小鼠在肠道或皮肤中不存在自然发生的微生物繁殖）身上。研究小组观察到，种植

虽然皮肤中的免疫细胞能保护机体免受有害生物的侵害，但到现在为止，皮肤中自然存在的数以百万计的共生细菌（统称为皮肤菌群）是否也具有有益作用。 皮肤免疫系统包括免疫细胞和免疫分子两部系，它们形成一个复杂的网络系统，并与体内其它免疫系统相互作用，共同维持着皮肤微环境和体内环境的稳定。皮肤免疫细胞包括角质形成细胞、淋巴细胞、朗格汉斯细胞、内皮细胞、肥大细胞、巨噬细胞、真皮成纤维细胞。皮肤免疫分包括细胞因子、免疫球蛋白、补体、神经肽。 根据一项新的宏基因组学研究，尽管经常清洗和接触富含细菌的物体，我们个人的皮肤微生物环境在一段时间后仍然保持高度稳定。这一认识可能能够被用来更好地理解一系列人类皮肤疾病，从而有助开发益菌素（prebiotic）、益生菌（probiotic）和微生物移植方法。相关研究结果发表在2016年5月5日那期Cell期刊上，论文标题为“Temporal Stability of the Human Skin Microbiome”。论文通信作者为来自美国国家癌症研究所的Heidi Kong和来自美国国家人类基因组研究所的Julie Segre。 人皮肤是一种生态系统，由各种各

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    2016-11-13 wjcjjian

    #微生物#

    0

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    2016-09-26 维他命

    #CEL#

    0

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    2017-03-30 zhaozhouchifen

    #Cell#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1824649, encodeId=595318246494e, content=<a href='/topic/show?id=702a5065860' target=_blank style='color:#2F92EE;'>#微生物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50658, encryptionId=702a5065860, topicName=微生物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Sun Nov 13 17:38:00 CST 2016, time=2016-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1959610, encodeId=d06a1959610fa, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Mon Sep 26 17:38:00 CST 2016, time=2016-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1869353, encodeId=201418693537b, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Thu Mar 30 02:38:00 CST 2017, time=2017-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=86047, encodeId=cf068604e24, content=好东西，学知识啦, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e1ee1610161, createdName=sundyli, createdTime=Mon May 16 22:59:00 CST 2016, time=2016-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85083, encodeId=754b8508329, content=学习共存, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e4e21675717, createdName=卡莲, createdTime=Mon May 09 17:13:00 CST 2016, time=2016-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1619309, encodeId=7d6316193095e, content=<a href='/topic/show?id=eb9150e29aa' target=_blank style='color:#2F92EE;'>#微生物菌群#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50729, encryptionId=eb9150e29aa, topicName=微生物菌群)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Sun May 08 13:38:00 CST 2016, time=2016-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=84706, encodeId=24cd84e0663, content=好高大上的感觉, beContent=null, objectType=article, channel=null, level=null, likeNumber=124, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Sun May 08 13:16:00 CST 2016, time=2016-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=84707, encodeId=79db84e0729, content=好高大上的感觉, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Sun May 08 13:16:00 CST 2016, time=2016-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=84701, encodeId=cf0b84e0125, content=好高大上的感觉, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Sun May 08 13:15:00 CST 2016, time=2016-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=84702, encodeId=db5b84e022f, content=好高大上的感觉, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Sun May 08 13:15:00 CST 2016, time=2016-05-08, status=1, ipAttribution=)]
    2016-05-16 sundyli

    好东西，学知识啦

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1824649, encodeId=595318246494e, content=<a href='/topic/show?id=702a5065860' target=_blank style='color:#2F92EE;'>#微生物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50658, encryptionId=702a5065860, topicName=微生物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Sun Nov 13 17:38:00 CST 2016, time=2016-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1959610, encodeId=d06a1959610fa, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Mon Sep 26 17:38:00 CST 2016, time=2016-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1869353, encodeId=201418693537b, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Thu Mar 30 02:38:00 CST 2017, time=2017-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=86047, encodeId=cf068604e24, content=好东西，学知识啦, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e1ee1610161, createdName=sundyli, createdTime=Mon May 16 22:59:00 CST 2016, time=2016-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85083, encodeId=754b8508329, content=学习共存, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e4e21675717, createdName=卡莲, createdTime=Mon May 09 17:13:00 CST 2016, time=2016-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1619309, encodeId=7d6316193095e, content=<a href='/topic/show?id=eb9150e29aa' target=_blank style='color:#2F92EE;'>#微生物菌群#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50729, encryptionId=eb9150e29aa, topicName=微生物菌群)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Sun May 08 13:38:00 CST 2016, time=2016-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=84706, encodeId=24cd84e0663, content=好高大上的感觉, beContent=null, objectType=article, channel=null, level=null, likeNumber=124, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Sun May 08 13:16:00 CST 2016, time=2016-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=84707, encodeId=79db84e0729, content=好高大上的感觉, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Sun May 08 13:16:00 CST 2016, time=2016-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=84701, encodeId=cf0b84e0125, content=好高大上的感觉, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Sun May 08 13:15:00 CST 2016, time=2016-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=84702, encodeId=db5b84e022f, content=好高大上的感觉, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Sun May 08 13:15:00 CST 2016, time=2016-05-08, status=1, ipAttribution=)]
    2016-05-09 卡莲

    学习共存

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1824649, encodeId=595318246494e, content=<a href='/topic/show?id=702a5065860' target=_blank style='color:#2F92EE;'>#微生物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50658, encryptionId=702a5065860, topicName=微生物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Sun Nov 13 17:38:00 CST 2016, time=2016-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1959610, encodeId=d06a1959610fa, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Mon Sep 26 17:38:00 CST 2016, time=2016-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1869353, encodeId=201418693537b, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Thu Mar 30 02:38:00 CST 2017, time=2017-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=86047, encodeId=cf068604e24, content=好东西，学知识啦, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e1ee1610161, createdName=sundyli, createdTime=Mon May 16 22:59:00 CST 2016, time=2016-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85083, encodeId=754b8508329, content=学习共存, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e4e21675717, createdName=卡莲, createdTime=Mon May 09 17:13:00 CST 2016, time=2016-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1619309, encodeId=7d6316193095e, content=<a href='/topic/show?id=eb9150e29aa' target=_blank style='color:#2F92EE;'>#微生物菌群#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50729, encryptionId=eb9150e29aa, topicName=微生物菌群)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Sun May 08 13:38:00 CST 2016, time=2016-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=84706, encodeId=24cd84e0663, content=好高大上的感觉, beContent=null, objectType=article, channel=null, level=null, likeNumber=124, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Sun May 08 13:16:00 CST 2016, time=2016-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=84707, encodeId=79db84e0729, content=好高大上的感觉, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Sun May 08 13:16:00 CST 2016, time=2016-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=84701, encodeId=cf0b84e0125, content=好高大上的感觉, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Sun May 08 13:15:00 CST 2016, time=2016-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=84702, encodeId=db5b84e022f, content=好高大上的感觉, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Sun May 08 13:15:00 CST 2016, time=2016-05-08, status=1, ipAttribution=)]
    2016-05-08 docwu2019

    #微生物菌群#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1824649, encodeId=595318246494e, content=<a href='/topic/show?id=702a5065860' target=_blank style='color:#2F92EE;'>#微生物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50658, encryptionId=702a5065860, topicName=微生物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Sun Nov 13 17:38:00 CST 2016, time=2016-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1959610, encodeId=d06a1959610fa, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Mon Sep 26 17:38:00 CST 2016, time=2016-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1869353, encodeId=201418693537b, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Thu Mar 30 02:38:00 CST 2017, time=2017-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=86047, encodeId=cf068604e24, content=好东西，学知识啦, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e1ee1610161, createdName=sundyli, createdTime=Mon May 16 22:59:00 CST 2016, time=2016-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85083, encodeId=754b8508329, content=学习共存, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e4e21675717, createdName=卡莲, createdTime=Mon May 09 17:13:00 CST 2016, time=2016-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1619309, encodeId=7d6316193095e, content=<a href='/topic/show?id=eb9150e29aa' target=_blank style='color:#2F92EE;'>#微生物菌群#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50729, encryptionId=eb9150e29aa, topicName=微生物菌群)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Sun May 08 13:38:00 CST 2016, time=2016-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=84706, encodeId=24cd84e0663, content=好高大上的感觉, beContent=null, objectType=article, channel=null, level=null, likeNumber=124, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Sun May 08 13:16:00 CST 2016, time=2016-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=84707, encodeId=79db84e0729, content=好高大上的感觉, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Sun May 08 13:16:00 CST 2016, time=2016-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=84701, encodeId=cf0b84e0125, content=好高大上的感觉, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Sun May 08 13:15:00 CST 2016, time=2016-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=84702, encodeId=db5b84e022f, content=好高大上的感觉, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Sun May 08 13:15:00 CST 2016, time=2016-05-08, status=1, ipAttribution=)]
    2016-05-08 stead

    好高大上的感觉

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1824649, encodeId=595318246494e, content=<a href='/topic/show?id=702a5065860' target=_blank style='color:#2F92EE;'>#微生物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50658, encryptionId=702a5065860, topicName=微生物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Sun Nov 13 17:38:00 CST 2016, time=2016-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1959610, encodeId=d06a1959610fa, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Mon Sep 26 17:38:00 CST 2016, time=2016-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1869353, encodeId=201418693537b, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Thu Mar 30 02:38:00 CST 2017, time=2017-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=86047, encodeId=cf068604e24, content=好东西，学知识啦, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e1ee1610161, createdName=sundyli, createdTime=Mon May 16 22:59:00 CST 2016, time=2016-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85083, encodeId=754b8508329, content=学习共存, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e4e21675717, createdName=卡莲, createdTime=Mon May 09 17:13:00 CST 2016, time=2016-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1619309, encodeId=7d6316193095e, content=<a href='/topic/show?id=eb9150e29aa' target=_blank style='color:#2F92EE;'>#微生物菌群#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50729, encryptionId=eb9150e29aa, topicName=微生物菌群)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Sun May 08 13:38:00 CST 2016, time=2016-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=84706, encodeId=24cd84e0663, content=好高大上的感觉, beContent=null, objectType=article, channel=null, level=null, likeNumber=124, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Sun May 08 13:16:00 CST 2016, time=2016-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=84707, encodeId=79db84e0729, content=好高大上的感觉, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Sun May 08 13:16:00 CST 2016, time=2016-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=84701, encodeId=cf0b84e0125, content=好高大上的感觉, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Sun May 08 13:15:00 CST 2016, time=2016-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=84702, encodeId=db5b84e022f, content=好高大上的感觉, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Sun May 08 13:15:00 CST 2016, time=2016-05-08, status=1, ipAttribution=)]
    2016-05-08 stead

    好高大上的感觉

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1824649, encodeId=595318246494e, content=<a href='/topic/show?id=702a5065860' target=_blank style='color:#2F92EE;'>#微生物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50658, encryptionId=702a5065860, topicName=微生物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Sun Nov 13 17:38:00 CST 2016, time=2016-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1959610, encodeId=d06a1959610fa, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Mon Sep 26 17:38:00 CST 2016, time=2016-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1869353, encodeId=201418693537b, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Thu Mar 30 02:38:00 CST 2017, time=2017-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=86047, encodeId=cf068604e24, content=好东西，学知识啦, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e1ee1610161, createdName=sundyli, createdTime=Mon May 16 22:59:00 CST 2016, time=2016-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85083, encodeId=754b8508329, content=学习共存, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e4e21675717, createdName=卡莲, createdTime=Mon May 09 17:13:00 CST 2016, time=2016-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1619309, encodeId=7d6316193095e, content=<a href='/topic/show?id=eb9150e29aa' target=_blank style='color:#2F92EE;'>#微生物菌群#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50729, encryptionId=eb9150e29aa, topicName=微生物菌群)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Sun May 08 13:38:00 CST 2016, time=2016-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=84706, encodeId=24cd84e0663, content=好高大上的感觉, beContent=null, objectType=article, channel=null, level=null, likeNumber=124, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Sun May 08 13:16:00 CST 2016, time=2016-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=84707, encodeId=79db84e0729, content=好高大上的感觉, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Sun May 08 13:16:00 CST 2016, time=2016-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=84701, encodeId=cf0b84e0125, content=好高大上的感觉, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Sun May 08 13:15:00 CST 2016, time=2016-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=84702, encodeId=db5b84e022f, content=好高大上的感觉, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Sun May 08 13:15:00 CST 2016, time=2016-05-08, status=1, ipAttribution=)]
    2016-05-08 stead

    好高大上的感觉

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=1824649, encodeId=595318246494e, content=<a href='/topic/show?id=702a5065860' target=_blank style='color:#2F92EE;'>#微生物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50658, encryptionId=702a5065860, topicName=微生物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Sun Nov 13 17:38:00 CST 2016, time=2016-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1959610, encodeId=d06a1959610fa, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Mon Sep 26 17:38:00 CST 2016, time=2016-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1869353, encodeId=201418693537b, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Thu Mar 30 02:38:00 CST 2017, time=2017-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=86047, encodeId=cf068604e24, content=好东西，学知识啦, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e1ee1610161, createdName=sundyli, createdTime=Mon May 16 22:59:00 CST 2016, time=2016-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=85083, encodeId=754b8508329, content=学习共存, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e4e21675717, createdName=卡莲, createdTime=Mon May 09 17:13:00 CST 2016, time=2016-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1619309, encodeId=7d6316193095e, content=<a href='/topic/show?id=eb9150e29aa' target=_blank style='color:#2F92EE;'>#微生物菌群#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50729, encryptionId=eb9150e29aa, topicName=微生物菌群)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Sun May 08 13:38:00 CST 2016, time=2016-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=84706, encodeId=24cd84e0663, content=好高大上的感觉, beContent=null, objectType=article, channel=null, level=null, likeNumber=124, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Sun May 08 13:16:00 CST 2016, time=2016-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=84707, encodeId=79db84e0729, content=好高大上的感觉, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Sun May 08 13:16:00 CST 2016, time=2016-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=84701, encodeId=cf0b84e0125, content=好高大上的感觉, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Sun May 08 13:15:00 CST 2016, time=2016-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=84702, encodeId=db5b84e022f, content=好高大上的感觉, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160509/IMG572FCF18A71237916.jpg, createdBy=d0861720708, createdName=stead, createdTime=Sun May 08 13:15:00 CST 2016, time=2016-05-08, status=1, ipAttribution=)]
    2016-05-08 stead

    好高大上的感觉

    0

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