Am J Kidney Dis:中国社区获得性急性肾损伤的地域特征有哪些?

2017-06-22 闫盈盈 吴刚 环球医学

2017年5月,发表在《Am J Kidney Dis》的一项由中国科学家进行的回顾性研究表明,中国不同地区中社区获得性AKI的特征存在大幅差异。

2017年5月,发表在《Am J Kidney Dis》的一项由中国科学家进行的回顾性研究表明,中国不同地区中社区获得性AKI的特征存在大幅差异。

背景:本研究旨在基于急性肾损伤(AKI)的全国调查,描述中国社区获得性AKI的负担。

研究设计:横断面、回顾性研究。

研究地点和参与者:使用的全国样本来自于中国大陆44家学术/区域医院的2223230名成年住院患者。根据2012年的KDIGO AKI肌酐标准或住院期间血清肌酐水平增加或降低50%定义AKI。入院时确定有AKI的患者鉴别为社区获得性AKI。

预测因素:社区获得性AKI的发生率、病因、识别和治疗根据患者入住的医院类型、纬度、区域经济发展情况进行分层。

结局:全因院内死亡率和出院时肾功能恢复。

结果:2个单月时间段(2013年1月和7月),共鉴别出4136名社区获得性AKI患者。其中,2020人(48.8%)为与肾脏血流灌注降低相关的病例,1111人(26.9%)为与内在肾病相关的病例,499人(12.1%)为与尿路梗阻相关的病例。北方vs南方,暴露于肾毒性物质或尿路梗阻的患者较多。536名社区获得性AKI患者(13.0%)具有肾脏替代治疗(RRT)的指征,但是仅有347人(64.7%)接受了RRT。及时诊断率和合理使用RRT在人均国内生产总值较高的地区更高。全因院内死亡率为7.3%(295/4068)。延迟识别AKI和位于中国北部为院内死亡率的独立风险因素,转诊到肾病科医生为独立的保护因素。

局限性:因无标准化的定义和血清肌酐数据的遗漏,因此可能错分AKI和社区获得性AKI。

结论:社区获得性AKI的特征在中国的不同地区具有大幅差异,与经济、环境和医疗资源密切相关。

原始出处:

Wang Y, Wang J, et al. Community-Acquired Acute Kidney Injury: A Nationwide Survey in China. Am J Kidney Dis. 2017 May;69(5):647-657. doi: 10.1053/j.ajkd.2016.10.034. 

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objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Thu Jun 22 22:15:47 CST 2017, time=2017-06-22, status=1, ipAttribution=)]
  5. 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objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Thu Jun 22 22:15:47 CST 2017, time=2017-06-22, status=1, ipAttribution=)]
    2017-06-24 gwc389
  6. 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objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Thu Jun 22 22:15:47 CST 2017, time=2017-06-22, status=1, ipAttribution=)]
    2017-06-23 dhzzm

    学习了分享了

    0

  7. 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content=学习了,谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Thu Jun 22 22:59:28 CST 2017, time=2017-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=214085, encodeId=4dd52140850e, content=好东西学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Thu Jun 22 22:21:02 CST 2017, time=2017-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=214077, encodeId=3ed22140e71c, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Thu Jun 22 22:15:47 CST 2017, time=2017-06-22, status=1, ipAttribution=)]
    2017-06-23 189****7206

    学习了谢谢分享

    0

  8. 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content=学习了,谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Thu Jun 22 22:59:28 CST 2017, time=2017-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=214085, encodeId=4dd52140850e, content=好东西学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Thu Jun 22 22:21:02 CST 2017, time=2017-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=214077, encodeId=3ed22140e71c, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Thu Jun 22 22:15:47 CST 2017, time=2017-06-22, status=1, ipAttribution=)]
    2017-06-22 惠映实验室

    学习了,谢谢分享。

    0

  9. 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encodeId=a2d6214242c7, content=学习了分享了, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387d1660055, createdName=dhzzm, createdTime=Fri Jun 23 07:52:37 CST 2017, time=2017-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=214122, encodeId=ff0421412211, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=08bb2061153, createdName=189****7206, createdTime=Fri Jun 23 00:03:50 CST 2017, time=2017-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=214103, encodeId=4b9721410380, content=学习了,谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Thu Jun 22 22:59:28 CST 2017, time=2017-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=214085, encodeId=4dd52140850e, content=好东西学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Thu Jun 22 22:21:02 CST 2017, time=2017-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=214077, encodeId=3ed22140e71c, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Thu Jun 22 22:15:47 CST 2017, time=2017-06-22, status=1, ipAttribution=)]
    2017-06-22 thlabcde

    好东西学习了!

    0

  10. 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objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Thu Jun 22 22:15:47 CST 2017, time=2017-06-22, status=1, ipAttribution=)]
    2017-06-22 清风拂面

    学习了,谢谢分享

    0

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,在中国不同地区的社区获得性AKI的特征变化较大,并且与环境、经济和医疗资源紧密联系在一起。

KIDNEY INT:社区获得性急性肾损伤增加慢性肾脏疾病和死亡风险

因此,社区获得性急性肾损伤明显增加CKD的风险,并适度增加死亡风险。研究结果强调了社区获得性急性肾损伤患者后续的随访的重要性,必要时可以及早开始肾保护措施。