CLIN CANCER RES：恩杂鲁胺对卡巴他赛药代动力学的影响

2018-02-25 MedSci MedSci原创

在转移性去势抵抗前列腺癌的临床研究中，目前正在探索紫杉烷类联合AR靶向药物，即恩杂鲁胺和阿比特龙的治疗效果是否可以得到增强。因为恩杂鲁胺可以诱导CYP3A4酶而紫杉烷类药物由这种酶代谢，需要研究其潜在的药物之间的相互作用。CLIN CANCER RES近期发表了一篇文章研究这一问题。

在转移性去势抵抗前列腺癌的临床研究中，目前正在探索紫杉烷类联合AR靶向药物，即恩杂鲁胺和阿比特龙的治疗效果是否可以得到增强。因为恩杂鲁胺可以诱导CYP3A4酶而紫杉烷类药物由这种酶代谢，需要研究其潜在的药物之间的相互作用。CLIN CANCER RES近期发表了一篇文章研究这一问题。

作者在接受卡巴他赛Q3W（25mg/m2）的转移性去势抵抗前列腺癌患者中进行该研究。患者进行3个连续周期的卡巴他赛治疗。恩杂鲁胺（160mg 每天1次）在第一个卡巴他赛周期后开始输入，持续6周时间。主要的研究终点为第一个周期（卡巴他赛单药）和第三个卡巴他赛周期（联合恩杂鲁胺）的平均曲线下面积（AUC）的差别。研究结果表明，联合恩杂鲁胺后，卡巴他赛暴露降低了22%。第三个周期卡巴他赛的平均AUC为181ng*h/mL，第一个周期为234ng*h/mL。这一联合策略并未导致毒性增强且PSA反应良好。

文章最后认为，联合恩杂鲁胺后卡巴他赛暴露显着下降。在研究转移性去势抵抗前列腺癌患者的联合治疗策略时，药物之间的相互作用十分重要。由于最近的研究支持使用更低剂量的卡巴他赛，这一药物之间的相互作用便更有意义，因为联合恩杂鲁胺可能会降低卡巴他赛暴露剂量。

原始出处：

Bodine P.S.Belderbos,Sander Bins,et al.Influence of Enzalutamide on Cabazitaxel Pharmacokinetics:a Drug-Drug Interaction Study in Metastatic Castration-resistant Prostate Cancer(mCRPC) Patients.CLIN CANCER RES.February 2018 doi:10.1158/1079-0432.CCR-17-2336

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2018-08-15 fengyqf

#药代#

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2018-02-27 lou.minghong

学习谢谢分享!

70 0
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2018-02-27 zhaojie88

#药代动力学#

35 0
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2018-02-26 sunfeifeiyang

阅

70 0
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2018-02-26 神功盖世

阅

64 0
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2018-02-25 wzb521zf

一起学习学习

58 0
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2018-02-25 1ddf0692m34(暂无匿称)

学习了.涨知识

62 0
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