解读《中国科学院“十三五”发展规划纲要》(生命科学部分)

2016-09-28 MedSci MedSci原创

8月31日,中国科学院在北京召开新闻发布会,发布了《中国科学院“十三五”发展规划纲要》(以下简称规划)。 规划主要围绕基础前沿交叉、先进材料、能源、生命与健康、海洋、资源生态环境、信息、光电空间等8大创新领域,中科院凝练提出了60项有望实现跨越发展的重大突破和80项塑造未来发展新优势的重点培育方向。 在这60项有望实现的重大突破中,“生命与健康”领域占17个。其中,针对神经、心血管、消

8月31日,中国科学院在北京召开新闻发布会,发布了《中国科学院“十三五”发展规划纲要》(以下简称规划)。


规划主要围绕基础前沿交叉、先进材料、能源、生命与健康、海洋、资源生态环境、信息、光电空间等8大创新领域,中科院凝练提出了60项有望实现跨越发展的重大突破和80项塑造未来发展新优势的重点培育方向。


在这60项有望实现的重大突破中,“生命与健康”领域占17个。其中,针对神经、心血管、消化、生殖及代谢等系统的重大疾病,中科院将以实现组织再生、器官修复、器官再造和替代为目标,解答细胞潜能及命运转变机制等基础性科学问题,研发器官修复及再造的关键技术。


按照规划,“十三五”时期,中科院将围绕基本实现“四个率先”目标,在全面深化改革的基础上,重点抓好研究所分类改革、人才发展体制机制改革、科技领域 “放管服” 改革、以重大科技成果产出为导向的资源配置体系改革、分类科技评价机制改革、促进国内外开放合作和资源共享等。


同时,中科院还将实施促进科技成果转移转化专项行动,重点推动一批基础好、见效快、带动性强的重大科技成果转化应用,并积极参与国家全面创新改革试验和北京、上海科技创新中心建设,支持区域创新体系建设和发展,支撑和服务“双创”。同时,加强党建和创新文化建设,积极开展科学普及等工作。

生命与健康( 17 个)

1. 健康方向

( 18)脑科学与类脑智能研究。 以脑认知功能的神经基础和类脑智能计算模型为核心科学问题,在脑科学、脑机智能技术和脑疾病早期诊断精准干预等前沿领域,取得国际领先的成果,促进我国人口健康与智能产业发展。

( 19) 生物超大分子复合体的结构、功能与调控。 以生命过程中重大基础科学问题为导向,以发展生物大分子复合体研究的新技术新方法为支撑,在染色质与遗传信息解码、膜蛋白结构功能、生物膜整合、病原体等超大分子机器等领域开展研究,在染色质高级结构、细胞自噬、真核膜蛋白、高致病性病原体、非编码核酸、原位生物成像等方向产出重大成果,推进对生命本质的认知与理解。

( 20) 细胞命运决定的分子调控。 围绕核酸修饰与代谢对表观遗传的调控、信号网络对细胞谱系建立的调控、亚细胞结构动态变化对细胞活动的调控三大主要内容,破解生物分子调控细胞增殖与运动、分化与转分化、凋亡与坏死、衰老与病变等奥秘。

( 21) 病原微生物与宿主免疫。 聚焦重要病原微生物的溯源与跨种传播机制及其与宿主的相互作用,研究病原微生物传播过程与突变规律、 病原微生物建立和维持感染的关键机制,以及宿主对病原体的免疫应答和保护等重要科学问题,为发展有效的传染病预防与治疗提供新靶标和新策略,为我国重大传染病防治提供理论基础。

( 22)个性化药物——基于疾病分子分型的普惠新药研发。 以肿瘤和代谢性疾病为核心,针对中国人群高发的肝癌、 胃癌、 Ⅱ型糖尿病等重大复杂性疾病,发展个性化药物研究的 新理论、新方法和新技术,推动实现从疾病分子分型到个性化 药物研发模式的变革。

( 23) 器官修复与再造。 针对神经、心血管、消化、生殖 及代谢等系统的重大疾病,以实现组织再生、器官修复、器官 再造和替代为目标,解答细胞潜能及命运转变机制等基础性科 学问题,研发器官修复及再造的关键技术,促进人民健康水平 提升和健康产业发展。

( 24)生物合成。 围绕绿色低碳可持续发展的需求,基于合成生物学和系统生物学等手段,重点发展酶催化体系及细胞 催化体系,实现重大化工产品的生物合成,发酵产品技术提升 以及重污染行业的绿色清洁生产,推动生物基材料产业发展, 发展单细胞高通量筛选等技术平台建设,在生物制造业领域实 现一批关键技术体系和代表产品的突破,推动产业竞争力提升。

( 25) 健康保障技术与装备。 以提高城乡居民体质机能、 慢病知晓率与控制率和健康老龄化为目标,综合应用生物、物 理、信息、工程材料等学科相关研究手段,开发健康辨识、评 估、决策、干预等各类健康管理技术与产品,开展基于生物传 感、穿戴设备和移动医疗技术的健康大数据收集、分析与应用。 研发临床急需的高端医疗装备和低成本系列化健康促进装备, 为建立普惠健康体系提供科技支撑。

塑造未来新优势的重点培育方向( 80 个, 不含国防科技创新)
生命与健康( 22 个)

1. 健康方向
( 27) 生物大数据研究
( 28) 核酸与人类健康
( 29) 灵长类动物表型与遗传
( 30) 细胞发育分化分子机理
( 31) 精准医学研究
( 32) 生殖生物学
( 33) 计算与系统生物学
( 34) 生物膜动态过程
( 35) 表观遗传调控与功能
( 36) 合成生物学
( 37) 先进生物制造
( 38) 生物安全科技支撑体系建设
( 39) 新型疫苗、抗体及生物类似物开发及评价技术
( 40) 重大和罕见疾病防治药物的作用新机制、新靶点和新策略研究

( 41) 生命科学新技术新方法
( 42) 生命科学与数理、化学、技术科学交叉前沿研究

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  4. 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GetPortalCommentsPageByObjectIdResponse(id=137322, encodeId=a49213e3224e, content=谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Wed Sep 28 20:55:59 CST 2016, time=2016-09-28, status=1, ipAttribution=)]
  5. 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  6. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=137324, encodeId=f34213e3248b, content=赞一个!, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Wed Sep 28 20:56:49 CST 2016, time=2016-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=137323, encodeId=81a213e32307, content=继续关注!, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Wed Sep 28 20:56:21 CST 2016, time=2016-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=137322, encodeId=a49213e3224e, content=谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Wed Sep 28 20:55:59 CST 2016, time=2016-09-28, status=1, ipAttribution=)]
    2016-10-20 respect
  7. [GetPortalCommentsPageByObjectIdResponse(id=1976216, encodeId=001a19e621656, content=<a href='/topic/show?id=ac3fe4911c3' target=_blank style='color:#2F92EE;'>#科学院#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74911, encryptionId=ac3fe4911c3, topicName=科学院)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c49e75, createdName=qjddjq, createdTime=Fri Jun 02 08:29:00 CST 2017, time=2017-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2070837, encodeId=2dce20e083741, content=<a href='/topic/show?id=29e36896181' target=_blank style='color:#2F92EE;'>#生命科学部#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68961, encryptionId=29e36896181, topicName=生命科学部)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8942242, createdName=jj000001, createdTime=Sun Feb 26 00:29:00 CST 2017, time=2017-02-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1647623, encodeId=8a20164e623c6, content=<a href='/topic/show?id=b08121943e9' target=_blank style='color:#2F92EE;'>#中国科学院#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=21943, encryptionId=b08121943e9, topicName=中国科学院)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=382d23462296, createdName=huperzia, createdTime=Thu May 25 23:29:00 CST 2017, time=2017-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1907275, encodeId=9921190e2754d, content=<a href='/topic/show?id=85fe35655ea' target=_blank style='color:#2F92EE;'>#十三五#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=35655, encryptionId=85fe35655ea, topicName=十三五)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a8e213, createdName=hongbochen, createdTime=Thu Sep 07 22:29:00 CST 2017, time=2017-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2024263, encodeId=2e42202426314, content=<a href='/topic/show?id=79f4219392b' target=_blank style='color:#2F92EE;'>#中国科学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=21939, encryptionId=79f4219392b, topicName=中国科学)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Thu Feb 09 01:29:00 CST 2017, time=2017-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1672433, encodeId=38b016e24336a, content=<a href='/topic/show?id=60819060283' target=_blank style='color:#2F92EE;'>#规划#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90602, encryptionId=60819060283, topicName=规划)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=676926912123, createdName=respect, createdTime=Thu Oct 20 19:29:00 CST 2016, time=2016-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1439513, encodeId=0fae1439513a4, content=<a href='/topic/show?id=3d52689512b' target=_blank style='color:#2F92EE;'>#生命科学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68951, encryptionId=3d52689512b, topicName=生命科学)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Fri Sep 30 05:29:00 CST 2016, time=2016-09-30, status=1, 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GetPortalCommentsPageByObjectIdResponse(id=137322, encodeId=a49213e3224e, content=谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Wed Sep 28 20:55:59 CST 2016, time=2016-09-28, status=1, ipAttribution=)]
  8. 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level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90602, encryptionId=60819060283, topicName=规划)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=676926912123, createdName=respect, createdTime=Thu Oct 20 19:29:00 CST 2016, time=2016-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1439513, encodeId=0fae1439513a4, content=<a href='/topic/show?id=3d52689512b' target=_blank style='color:#2F92EE;'>#生命科学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68951, encryptionId=3d52689512b, topicName=生命科学)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Fri Sep 30 05:29:00 CST 2016, time=2016-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=137324, encodeId=f34213e3248b, content=赞一个!, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Wed Sep 28 20:56:49 CST 2016, time=2016-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=137323, encodeId=81a213e32307, content=继续关注!, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Wed Sep 28 20:56:21 CST 2016, time=2016-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=137322, encodeId=a49213e3224e, content=谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Wed Sep 28 20:55:59 CST 2016, time=2016-09-28, status=1, ipAttribution=)]
    2016-09-28 知难而进

    赞一个!

    0

  9. 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level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90602, encryptionId=60819060283, topicName=规划)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=676926912123, createdName=respect, createdTime=Thu Oct 20 19:29:00 CST 2016, time=2016-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1439513, encodeId=0fae1439513a4, content=<a href='/topic/show?id=3d52689512b' target=_blank style='color:#2F92EE;'>#生命科学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68951, encryptionId=3d52689512b, topicName=生命科学)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Fri Sep 30 05:29:00 CST 2016, time=2016-09-30, status=1, 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GetPortalCommentsPageByObjectIdResponse(id=137322, encodeId=a49213e3224e, content=谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Wed Sep 28 20:55:59 CST 2016, time=2016-09-28, status=1, ipAttribution=)]
    2016-09-28 知难而进

    继续关注!

    0

  10. 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GetPortalCommentsPageByObjectIdResponse(id=137322, encodeId=a49213e3224e, content=谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Wed Sep 28 20:55:59 CST 2016, time=2016-09-28, status=1, ipAttribution=)]
    2016-09-28 知难而进

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