J Periodontol:新鲜!重型地中海贫血可影响牙周组织的健康

2015-06-03 MedSci MedSci原创

J Periodontol:新鲜!重型地中海贫血可影响牙周组织的健康近日,土耳其牙医学院牙周科的研究人员研究表明,重型地中海贫血可潜在的影响全身的血液状况,并可通过降低淋巴细胞的活性提高破骨细胞的活性来影响牙龈炎症。该研究成果于2015年3月在线发表于JOURNAL OF PERIODONTOLOGY《牙周病学杂志》。该研究采用横断面研究,旨在比较伴或不伴有牙龈炎的重型地中海贫血患者(TM)体液中

近日,土耳其牙医学院牙周科的研究人员研究表明,重型地中海贫血可潜在的影响全身的血液状况,并可通过降低淋巴细胞的活性提高破骨细胞的活性来影响牙龈炎症。该研究成果于2015年3月在线发表于JOURNAL OF PERIODONTOLOGY《牙周病学杂志》。


该研究采用横断面研究,旨在比较伴或不伴有牙龈炎的重型地中海贫血患者(TM)体液中局部和全身的 sRANKL,OPG,APRIL,BAFF,IL-6 和 IL-8的水平。

研究共纳入77例患者(TM:n=29;身体健康: n=48)。使用ELISA测定龈沟液(GCF),唾液以及血清中 IL-6, IL-8,受体活化的核因子-κB配体(sRANKL),骨保护素(OPG) ,B细胞活化因子(BAFF),增值诱导配体(APRIL)。采用合适的非参数和参数统计检验分析数据。

结果发现,TM牙龈炎患者中GCF,唾液以及血清中 BAFF (p<0.001), IL-6 以及 IL-8 (p<0.005)的水平高于无TM身体健康的牙龈炎患者 (p<0.001)。TM患者的GCF,唾液以及血清中APRIL,sRANKL,IL-6, IL-8的水平高于全身以及牙周健康对照组 (p<0.05)。 TM组中,BOP及PI得分与 GCF中 APRIL的水平以及血清中sRANKL ,OPG和sRANKL 的水平呈正相关(p<0.05)。同样在全身健康组中也发现,BOP及PI得分,与体液中各种标志物的参数呈明显的正相关。

原始出处:

Akcalı A, Kahraman Çeneli S, Gümüş P, Buduneli N, Lappin DF, Özçaka Ö.The Association Between Thalassemia Major and Periodontal Health.J Periodontol. 2015 May 13:1-17.

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    2016-09-13 1e10c84am36(暂无匿称)

    好文章,还会关注

    0

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    2016-03-23 feather89
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    2015-06-09 ljjj1053

    认真学习了

    0

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    2015-06-06 s312486

    肯定的

    0

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  7. [GetPortalCommentsPageByObjectIdResponse(id=125059, encodeId=e5fc12505998, content=好文章,还会关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Tue Sep 13 11:53:00 CST 2016, time=2016-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1725855, encodeId=3c941e2585550, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Wed Mar 23 22:21:00 CST 2016, time=2016-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1969704, encodeId=61a71969e041e, content=<a href='/topic/show?id=641e6e5300d' target=_blank style='color:#2F92EE;'>#牙周组织#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67530, encryptionId=641e6e5300d, topicName=牙周组织)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=58df296, createdName=shock_melon, createdTime=Fri Jun 26 05:21:00 CST 2015, time=2015-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=26593, encodeId=631a26593b1, content=认真学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=136, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=ac181616815, createdName=ljjj1053, createdTime=Tue Jun 09 17:46:00 CST 2015, time=2015-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=26144, encodeId=e1bf2614432, content=肯定的, beContent=null, objectType=article, channel=null, level=null, likeNumber=152, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a7911626942, createdName=s312486, createdTime=Sat Jun 06 07:06:00 CST 2015, time=2015-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450420, encodeId=d1e61450420f8, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Fri Jun 05 03:21:00 CST 2015, time=2015-06-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1575429, encodeId=547b15e542960, content=<a href='/topic/show?id=cd9941326bc' target=_blank style='color:#2F92EE;'>#地中海#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41326, encryptionId=cd9941326bc, topicName=地中海)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=303116130321, createdName=wgx311, createdTime=Fri Jun 05 03:21:00 CST 2015, time=2015-06-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25871, encodeId=6ee4258e18a, content=牙齿可受累, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6e511627114, createdName=1dd7eb8am26(暂无匿称), createdTime=Wed Jun 03 21:38:00 CST 2015, time=2015-06-03, status=1, ipAttribution=)]
    2015-06-05 wgx311
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    2015-06-03 1dd7eb8am26(暂无匿称)

    牙齿可受累

    0

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