Nutr Metab Cardiovasc Dis:老年人颈动脉粥样硬化斑块的强烈预测因素

2018-02-11 吴星 环球医学

2018年1月,发表在《Nutr Metab Cardiovasc Dis》的一项由意大利科学家进行的研究表明,嗜中性粒细胞与淋巴细胞比值(NLR)是老年人颈动脉粥样硬化斑块的强烈预测因素。

2018年1月,发表在《Nutr Metab Cardiovasc Dis》的一项由意大利科学家进行的研究表明,嗜中性粒细胞与淋巴细胞比值(NLR)是老年人颈动脉粥样硬化斑块的强烈预测因素。

背景和目的:NLR是全身性炎症的指数,已有研究报告NLR与亚临床动脉粥样硬化相关,但是其在颈动脉粥样硬化斑块中的预测作用仍未确定。本研究旨在评估老年人中,给予此生物标志物额外价值的此相关性,在主要风险因素方面,在颈动脉粥样硬化预测中的作用。

方法和结果:研究者招募了2014年1月~2016年12月324例≥65岁的无造血系统疾病和/或恶性肿瘤史的患者,这些患者无急性感染、慢性炎症状态和过去3个月内糖皮质激素治疗史证据,入住到意大利卡塔尼亚大学内科单元。所有患者都采集血液,用以分析白细胞、嗜中性粒细胞、淋巴细胞和血小板计数,并测量了炎症标志物,NLR的计算方法为绝对嗜中性粒细胞计数与绝对淋巴细胞计数的比值。患者也使用超声检查(US)进行了颈动脉扫描,从而评估颈动脉壁异常。NLR为颈动脉斑块的强烈预测因素。NLR>2.4预测颈动脉斑块的概率为80%(P<0.01),而NLR>3.68的概率为97%(P=0.013)。此外,NLR>2.4与平均存在2.86个颈动脉斑块相关(P<0.001)。纤维蛋白原和CRP作为颈动脉斑块的预测因素也很好,但是显著性稍低(P=0.002)。

结论:NLR为颈动脉粥样硬化斑块存在和数量的强烈预测因素。NLR在鉴别隐匿的颈动脉斑块风险中具有重要作用。

原始出处:

Corriere T, Di Marca S, Cataudella E, et.al. Neutrophil-to-Lymphocyte Ratio is a strong predictor of atherosclerotic carotid plaques in older adults. Nutr Metab Cardiovasc Dis. 2018 Jan

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    2018-09-07 guojianrong
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    2018-09-14 一闲
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target=_blank style='color:#2F92EE;'>#预测因素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100226, encryptionId=daf1100226fb, topicName=预测因素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a57b78, createdName=朱睿睿, createdTime=Tue Feb 13 09:56:00 CST 2018, time=2018-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1330072, encodeId=cf2513300e225, content=<a href='/topic/show?id=a91c5e92328' target=_blank style='color:#2F92EE;'>#斑块#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57923, encryptionId=a91c5e92328, topicName=斑块)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/4E6244DB7C1860858424437821E08291/100, createdBy=a6a52500039, createdName=ms3994565386320060, createdTime=Tue Feb 13 09:56:00 CST 2018, time=2018-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1459365, encodeId=96691459365a6, content=<a href='/topic/show?id=477610056158' target=_blank style='color:#2F92EE;'>#颈动脉粥样硬化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100561, encryptionId=477610056158, topicName=颈动脉粥样硬化)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=88db6138923, createdName=经常头晕, createdTime=Tue Feb 13 09:56:00 CST 2018, time=2018-02-13, status=1, ipAttribution=)]
    2018-12-29 quxin068
  5. 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  6. 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  7. 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    2018-02-19 zwjnj2

    好好好好

    0

  8. 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