诺贝尔生理学医学奖大隅良典自称性情乖僻,做没人做的事很快乐

2016-10-04 MedSci MedSci原创

瑞典的卡罗林斯卡学院3日宣布,2016年诺贝尔生理学医学奖将授予东京工业大学名誉教授大隅良典(Yoshinori Ohsumi),表彰其探明了细胞分解自身蛋白质进行循环利用的自噬作用的机理。大隅自认有“乖僻”精神,这让他在科学研究上有所斩获。 自噬作用被认为是确保细胞正常工作的基础性机理。若有异常,就可能导致癌症或阿尔茨海默症等众多疾病。这项被期待也有助于今后药品研发的研究此次获得了最高荣誉

瑞典的卡罗林斯卡学院3日宣布,2016年诺贝尔生理学医学奖将授予东京工业大学名誉教授大隅良典(Yoshinori Ohsumi),表彰其探明了细胞分解自身蛋白质进行循环利用的自噬作用的机理。大隅自认有“乖僻”精神,这让他在科学研究上有所斩获。

自噬作用被认为是确保细胞正常工作的基础性机理。若有异常,就可能导致癌症或阿尔茨海默症等众多疾病。这项被期待也有助于今后药品研发的研究此次获得了最高荣誉。获悉得奖后,大隅表示:“对单独获得该奖项感到吃惊。我觉得非常荣幸。”

大隅这样形容自己:“我讨厌与人竞争,没人做的领域,我身为先锋,开疆辟土,这样比较快乐。”(其实,我也讨厌与人竞争,但是原创性发现,哪里有,哪里有,哪里有?)

大隅在获得诺贝尔奖之前就曾说过:“觉得自己在做的事有乐趣,这对科学来讲,是最重要的。现在细胞自噬作用的研究成了‘流行’,反而让我觉得不太舒服。我这个人性情就是有点乖僻。”(小编:盘算一下,小编性格也挺乖僻,会不会有得奖的可能?大家给我一个辛苦奖吧)

据报道,71岁的大隅研究酵母约40年,这研究主题原本是不获其他研究人员青睐的领域,他之所以专注于这研究主题,是因为他有乖僻精神。(小编:小编离71岁还有近50年!有希望,不好意思,暴露年龄了)

大隅生于福冈市,家中4个小孩,他是老幺。父亲大隅芳雄是九州岛大学工学部矿山学的教授。他家住在福冈市郊外,朋友大多是农家子弟,常在大自然的环境中一起游玩、他很喜爱抓昆虫。

大隅就读小学时,大他12岁、在东京念大学的哥哥返家,买了一本有关宇宙、生物以及化学的书籍送给他,当时大隅很感动,心想哥哥在东京过着穷学生的日子,竟还买书送他,不过这本书也影响大隅甚深,让他立志日后要从事自然科学研究。

在就读福冈高中时,大隅隶属于化学部。原本他想专攻化学,但就读东京大学时,遇到研究阿兹海默症的权威、名誉教授今堀和友,让大隅后来也立志专攻生物学。(小编:曾经多少广告鼓吹21世纪是生物医学的世纪,小编从此入错行了)

大隅后来到美国留学,在研究过程中接触到“酵母”的研究主题,这改变了他的命运。

大隅留学归国,在东京大学担任助教授时,持续以显微镜观察酵母细胞内的“液胞”,创造了他今天能获得诺贝尔奖的开端。

他说:“我所走的路都是很细很细的,但小小的发现,能造成大漩涡”(梅斯医学小编:感觉我天天的工作也是很细很细的,偷笑)。

大隅1988年成为助教授时,已43岁、升为教授是在51岁那年,并不算早。细胞自噬作用的研究在当时是不获其他学者青睐的。但他没改变志向去追求容易拿到研究费、易写出论文的“流行”研究主题。(果然偏执,不喜欢流行,在中国,估计得要下岗或被淘汰了)

对于现代年轻学者有追求眼前成果的倾向,大隅表示,科学本来就无法预估前景的,或许科学无法立刻显现出成果,但可以挑战与众不同或有趣的事务。他希望未来也能营造这样的环境。

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    2016-10-07 童小孩

    !_!

    0

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  6. 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    2016-10-05 少年尼采

    小编不害羞吗 当然那点奖金还不够魔都半套房子

    0

  7. 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createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K3j7ibEWPiarwpqibEYqqX9yVibV5uebib0O7hQSOPmqGrb5FfyDbLsLawnz7ShAb5ibtiayWgI5ClMTh5v/0, createdBy=a47c1614293, createdName=童小孩, createdTime=Fri Oct 07 07:50:45 CST 2016, time=2016-10-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1543472, encodeId=c88715434e2d4, content=<a href='/topic/show?id=274e340e5fd' target=_blank style='color:#2F92EE;'>#医学奖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=34075, encryptionId=274e340e5fd, topicName=医学奖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=250d13588803, createdName=斯嘉莉, createdTime=Thu Oct 06 06:14:00 CST 2016, time=2016-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140392, encodeId=ac1b14039287, content=小编不害羞吗 当然那点奖金还不够魔都半套房子, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=10071932021, createdName=少年尼采, createdTime=Wed Oct 05 14:46:41 CST 2016, time=2016-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140391, encodeId=456614039134, content=学习了,值得借鉴!, beContent=null, objectType=article, channel=null, level=null, likeNumber=1, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCEEr4dM45RatXXGAkFCicnNYiasFiaRicicO1YWsIeTFOhgapauqib8Z8TChNB3ttVC5RqNHptDvAxA72Q/0, createdBy=a82a1611288, createdName=yydlt, createdTime=Wed Oct 05 14:32:11 CST 2016, time=2016-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140360, encodeId=0aa5140360a0, content=在中国行不通,社会太浮躁了,国家科学理念要改变!, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=51721924864, createdName=1e0b7131m82(暂无匿称), createdTime=Wed Oct 05 11:05:13 CST 2016, time=2016-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140347, encodeId=de2114034e26, content=低调做人高调做事, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K3j7ibEWPiarwpqibEYqqX9yVibV5uebib0O7hQSOPmqGrb5FfyDbLsLawnz7ShAb5ibtiayWgI5ClMTh5v/0, createdBy=a47c1614293, createdName=童小孩, createdTime=Wed Oct 05 10:14:41 CST 2016, time=2016-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140294, encodeId=09e814029417, content=这样的人大多情况下会有大成就, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K3j7ibEWPiarwpqibEYqqX9yVibV5uebib0O7hQSOPmqGrb5FfyDbLsLawnz7ShAb5ibtiayWgI5ClMTh5v/0, createdBy=a47c1614293, createdName=童小孩, createdTime=Wed Oct 05 07:49:50 CST 2016, time=2016-10-05, status=1, ipAttribution=)]
    2016-10-05 yydlt

    学习了,值得借鉴!

    0

  8. 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likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=10071932021, createdName=少年尼采, createdTime=Wed Oct 05 14:46:41 CST 2016, time=2016-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140391, encodeId=456614039134, content=学习了,值得借鉴!, beContent=null, objectType=article, channel=null, level=null, likeNumber=1, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCEEr4dM45RatXXGAkFCicnNYiasFiaRicicO1YWsIeTFOhgapauqib8Z8TChNB3ttVC5RqNHptDvAxA72Q/0, createdBy=a82a1611288, createdName=yydlt, createdTime=Wed Oct 05 14:32:11 CST 2016, time=2016-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140360, encodeId=0aa5140360a0, content=在中国行不通,社会太浮躁了,国家科学理念要改变!, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=51721924864, createdName=1e0b7131m82(暂无匿称), createdTime=Wed Oct 05 11:05:13 CST 2016, time=2016-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140347, encodeId=de2114034e26, content=低调做人高调做事, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K3j7ibEWPiarwpqibEYqqX9yVibV5uebib0O7hQSOPmqGrb5FfyDbLsLawnz7ShAb5ibtiayWgI5ClMTh5v/0, createdBy=a47c1614293, createdName=童小孩, createdTime=Wed Oct 05 10:14:41 CST 2016, time=2016-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140294, encodeId=09e814029417, content=这样的人大多情况下会有大成就, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K3j7ibEWPiarwpqibEYqqX9yVibV5uebib0O7hQSOPmqGrb5FfyDbLsLawnz7ShAb5ibtiayWgI5ClMTh5v/0, createdBy=a47c1614293, createdName=童小孩, createdTime=Wed Oct 05 07:49:50 CST 2016, time=2016-10-05, status=1, ipAttribution=)]
    2016-10-05 1e0b7131m82(暂无匿称)

    在中国行不通,社会太浮躁了,国家科学理念要改变!

    0

  9. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=51721924864, createdName=1e0b7131m82(暂无匿称), createdTime=Wed Oct 05 11:05:13 CST 2016, time=2016-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140347, encodeId=de2114034e26, content=低调做人高调做事, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K3j7ibEWPiarwpqibEYqqX9yVibV5uebib0O7hQSOPmqGrb5FfyDbLsLawnz7ShAb5ibtiayWgI5ClMTh5v/0, createdBy=a47c1614293, createdName=童小孩, createdTime=Wed Oct 05 10:14:41 CST 2016, time=2016-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140294, encodeId=09e814029417, content=这样的人大多情况下会有大成就, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K3j7ibEWPiarwpqibEYqqX9yVibV5uebib0O7hQSOPmqGrb5FfyDbLsLawnz7ShAb5ibtiayWgI5ClMTh5v/0, createdBy=a47c1614293, createdName=童小孩, createdTime=Wed Oct 05 07:49:50 CST 2016, time=2016-10-05, status=1, ipAttribution=)]
    2016-10-05 童小孩

    低调做人高调做事

    0

  10. 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likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=10071932021, createdName=少年尼采, createdTime=Wed Oct 05 14:46:41 CST 2016, time=2016-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140391, encodeId=456614039134, content=学习了,值得借鉴!, beContent=null, objectType=article, channel=null, level=null, likeNumber=1, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLCEEr4dM45RatXXGAkFCicnNYiasFiaRicicO1YWsIeTFOhgapauqib8Z8TChNB3ttVC5RqNHptDvAxA72Q/0, createdBy=a82a1611288, createdName=yydlt, createdTime=Wed Oct 05 14:32:11 CST 2016, time=2016-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140360, encodeId=0aa5140360a0, content=在中国行不通,社会太浮躁了,国家科学理念要改变!, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=51721924864, createdName=1e0b7131m82(暂无匿称), createdTime=Wed Oct 05 11:05:13 CST 2016, time=2016-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140347, encodeId=de2114034e26, content=低调做人高调做事, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K3j7ibEWPiarwpqibEYqqX9yVibV5uebib0O7hQSOPmqGrb5FfyDbLsLawnz7ShAb5ibtiayWgI5ClMTh5v/0, createdBy=a47c1614293, createdName=童小孩, createdTime=Wed Oct 05 10:14:41 CST 2016, time=2016-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140294, encodeId=09e814029417, content=这样的人大多情况下会有大成就, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K3j7ibEWPiarwpqibEYqqX9yVibV5uebib0O7hQSOPmqGrb5FfyDbLsLawnz7ShAb5ibtiayWgI5ClMTh5v/0, createdBy=a47c1614293, createdName=童小孩, createdTime=Wed Oct 05 07:49:50 CST 2016, time=2016-10-05, status=1, ipAttribution=)]
    2016-10-05 童小孩

    这样的人大多情况下会有大成就

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