Psychother Psychosom:加拿大研究称,抗抑郁药或显著增加死亡风险

2017-09-25 朱柳媛 中国循环杂志

现代社会,很多人遭受着各种各样的压力,抑郁、焦虑等精神症状越来越常见。据估计,美国大约1/10的人需要依赖抗抑郁药。

现代社会,很多人遭受着各种各样的压力,抑郁、焦虑等精神症状越来越常见。据估计,美国大约1/10的人需要依赖抗抑郁药。

近期,来自加拿大麦克马斯特大学的一项Meta分析提示,百忧解(氟西汀)、西酞普兰等常用的抗抑郁药可显着升高死亡风险。

与不用抗抑郁药的人相比,经常服用抗抑郁药的人早死的风险增加33%,出现不良心血管事件(脑卒中或心脏病)的风险增加14%。

不过,对于已有心脏病或糖尿病的人来说,抗抑郁药并没有明显的不良影响。研究者推测,这可能与抗抑郁药有一定的抗凝作用有关。

研究者指出,大多数抗抑郁药通过阻止神经元对5- 羟色胺的摄取而发挥作用,而心脏、肾脏、肺、肝脏等重要器官去需要应用5- 羟色胺而发挥其功能。因此,抗抑郁药可能通过阻碍多数器官的正常功能而升高死亡风险。

这项Meta分析共纳入16项相关研究,覆盖大约37.5万例受试者。

原始出处:
Marta M. Maslej, Benjamin M. Bolker, Marley J. Russell, et al. The Mortality and Myocardial Effects of Antidepressants Are Moderated by Preexisting Cardiovascular Disease: A Meta-Analysis. Psychotherapy and Psychosomatics, 2017; 268 DOI: 10.1159/000477940

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    2018-08-16 wetgdt
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    2017-09-26 138****9420

    希望在引用文献时.将影响机制.讨论等内容描述的更详细些.谢谢!

    0

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    2017-09-26 sunfeifeiyang

    什么药用多了都不好

    0

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    2017-09-25 1ddf0692m34(暂无匿称)

    学习了.涨知识

    0

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【血清素能够加重抑郁患者耳鸣】我们也许都经历过耳鸣,耳鸣会使人感到烦躁和焦虑。来自OHSU的科学家的研究表明,常见的抗抑郁药物可能会使耳鸣情况恶化。

Int J Cancer:抗抑郁药或能降低卵巢上皮癌的风险

卵巢上皮癌是常见的妇科恶性肿瘤,占卵巢肿瘤的;50%-70%.由于EOC早期(I、II期)缺乏典型临床表观。76%的病人在发现时已有腹腔内种植,肝实质和/或胸腔、颅内转移(III、IV期)这是导致较高病死率的主要原因。 抗抑郁药治疗在女性中被广泛使用,主要治疗抑郁症和焦虑症,但目前很少有研究探讨抗抑郁药对妇科癌症风险的影响。

[重复]JAMA:妊娠初期母亲使用抗抑郁药对子代有何影响?

有研究显示,出生前暴露于抗抑郁药与不良结局相关。然而,既往研究可能对混杂的解释不足。2017年4月,发表在《JAMA》的一项回顾性队列研究调查了妊娠初期母亲使用抗抑郁药与子代早产、小于胎龄儿、自闭症谱系障碍和注意力缺陷/多动障碍的相关性。