Int J Oncol：PPI或可有效治疗前列腺癌

2018-07-02 MedSci MedSci原创

Polyphyllin I（PPI）是一种天然化合物，从巴黎鸢尾根茎中提取，用于治疗发烧和头痛。在本研究中，研究人员评估了PPI在前列腺癌（PC）细胞中的抗肿瘤活性。在低剂量下，PPI可降低PC细胞的增殖、侵袭和上皮-间充质转化（EMT）。PPI降低了对肿瘤转移至关重要的基质金属蛋白酶7（MMP7）的表达，还降低了与EMT相关的因素Snail和波形蛋白的表达。此外，PPI抑制AP-1转录活性以及A

Polyphyllin I（PPI）是一种天然化合物，从巴黎鸢尾根茎中提取，用于治疗发烧和头痛。在本研究中，研究人员评估了PPI在前列腺癌（PC）细胞中的抗肿瘤活性。

在低剂量下，PPI可降低PC细胞的增殖、侵袭和上皮-间充质转化（EMT）。PPI降低了对肿瘤转移至关重要的基质金属蛋白酶7（MMP7）的表达，还降低了与EMT相关的因素Snail和波形蛋白的表达。此外，PPI抑制AP-1转录活性以及AP-1与MMP7和波形蛋白启动子的结合。

结果表明，PPI下调胞外信号相关激酶（ERK）的磷酸化，ERK是AP-1的上游调节剂。PPI可能通过抑制蛋白磷酸酶2A（CIP2A）/蛋白磷酸酶2A（PP2A）/ERK轴抑制剂，下调MMP7、vimentin和Snail的表达，抑制肿瘤侵袭和EMT。PC异种移植小鼠模型中发现，PPI可降低肿瘤生长和体重。此外，PPI还可抑制PPI治疗的肿瘤中的增殖细胞核抗原表达和CIP2A/PP2A/ERK信号传导通路。

综上所述，本研究的结果表明，PPI可通过抑制CIP2A/PP2A/ERK信号轴来抑制PC细胞的生长、侵袭和EMT。因此，PPI或可用于治疗PC。

原始出处：

Liu X, Sun Z, et al., Polyphyllin I inhibits invasion and epithelial-mesenchymal transition via CIP2A/PP2A/ERK signaling in prostate cancer. Int J Oncol. 2018 Jun 29. doi: 10.3892/ijo.2018.4464.

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2019-02-22 minlingfeng

#Oncol#

26 0
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2018-07-05 1e1c07bdm01(暂无匿称)

好

51 0
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2018-07-04 docwu2019

#有效治疗#

27 0
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2018-07-04 1e1c07bdm01(暂无匿称)

好

55 0
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2018-07-03 kafei

学习了谢谢

0 0
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2018-07-03 1dd8c52fm63(暂无匿称)

了解了解.继续关注

53 0
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2018-07-03 1e1c07bdm01(暂无匿称)

好

51 0
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2018-07-03 yjs木玉

好好好好好好好好

24 0
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2018-07-03 phoebeyan520

学习了.谢谢分享

19 0
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2018-07-03 飛歌

厉害了我的哥

29 0

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