ASCO 2022:肝细胞癌患者肝移植后 30 天再入院率的预测因素

2022-06-01 MedSci原创 MedSci原创

肝移植术后再入院与较高的死亡率相关,并导致较高的医疗保健负担。

肝移植对肝细胞癌(HCC)患者来说是一种有效的手段,手术效果良好,术后可恢复正常工作学习生活。然而,HCC患者肝移植后再入院很常见,且可能与医疗负担增加有关。

近期,在ASCO大会上,研究人员进行了一项回顾性研究,该研究收纳了来自2017 年全国再入院数据库 (NRD) 的肝移植后30 天再内再入院的肝细胞癌患者,并对其进行基础诊断。对于肝硬化患者中,研究人员使用BAVENO评分来划分代偿性肝硬化和失代偿性肝硬化。研究主要目的是确定接受肝移植手术的患者 30 天再入院率、死亡率、与医疗保健相关资源的消耗和再入院的独立预测因素。

结果显示,共有 2092 名 HCC 患者接受了肝移植。30天再入院率为25.6%。再入院的主要原因是肝移植手术后的并发症、败血症和肝衰竭。再入院的患者不太可能有私人保险(40.5% vs 34.5%;P<0.01)、肥胖(18.2% vs 7.9%;P<0.01)、高血压(51.2% vs 39.5%;P<0.01)、非酒精性脂肪性肝炎病史(16.5% vs 2.3%;P<0.01)。

肝移植后,患者再次入院的因素

另外,再入院与较高的院内死亡相关(0.1% vs. 1.5%;P<0.01)。再入院的总医疗保健经济负担为 5610 万美元。再入院的独立预测因素是2型糖尿病、入院期间输血产品、蛋白质-热量营养不良、败血症。

总之,肝移植术后再入院与较高的死亡率相关,并导致较高的医疗保健负担。研究确定了可以针对的风险因素,以减少患者的总体发病率、死亡率和医疗负担。

原始出处

Miguel Salazar, Shristi Upadhyay Upadhyay Banskota, Lou Anne Acevedo, Pedro Palacios, Estefania Gauto, Binav Baral, Trilok Shrivastava, Nabin Khanal.Predictors of 30-day readmission rate after liver transplant in patients with hepatocellular carcinoma.

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1939379, encodeId=9c0519393e9f4, content=<a href='/topic/show?id=1c292818fd' target=_blank style='color:#2F92EE;'>#ASC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2818, encryptionId=1c292818fd, topicName=ASC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Sun Aug 14 16:37:36 CST 2022, time=2022-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1863672, encodeId=0aca18636e2cc, content=<a href='/topic/show?id=c0b68135561' target=_blank style='color:#2F92EE;'>#肝细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81355, encryptionId=c0b68135561, topicName=肝细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Sat Mar 04 22:37:36 CST 2023, time=2023-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1979340, encodeId=810219e934067, content=<a href='/topic/show?id=3b90e79787f' target=_blank style='color:#2F92EE;'>#细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77978, encryptionId=3b90e79787f, topicName=细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Wed Apr 12 23:37:36 CST 2023, time=2023-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1264405, encodeId=f7f412644054b, content=<a href='/topic/show?id=daf1100226fb' target=_blank style='color:#2F92EE;'>#预测因素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100226, encryptionId=daf1100226fb, topicName=预测因素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a57b78, createdName=朱睿睿, createdTime=Fri Jun 03 02:37:36 CST 2022, time=2022-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1529996, encodeId=e4bc15299965e, content=<a href='/topic/show?id=bcc5306146d' target=_blank style='color:#2F92EE;'>#再入院率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30614, encryptionId=bcc5306146d, topicName=再入院率)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6a1e11986162, createdName=yzh403, createdTime=Fri Jun 03 02:37:36 CST 2022, time=2022-06-03, status=1, ipAttribution=)]
    2022-08-14 quxin068
  2. [GetPortalCommentsPageByObjectIdResponse(id=1939379, encodeId=9c0519393e9f4, content=<a href='/topic/show?id=1c292818fd' target=_blank style='color:#2F92EE;'>#ASC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2818, encryptionId=1c292818fd, topicName=ASC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Sun Aug 14 16:37:36 CST 2022, time=2022-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1863672, encodeId=0aca18636e2cc, content=<a href='/topic/show?id=c0b68135561' target=_blank style='color:#2F92EE;'>#肝细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81355, encryptionId=c0b68135561, topicName=肝细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Sat Mar 04 22:37:36 CST 2023, time=2023-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1979340, encodeId=810219e934067, content=<a href='/topic/show?id=3b90e79787f' target=_blank style='color:#2F92EE;'>#细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77978, encryptionId=3b90e79787f, topicName=细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Wed Apr 12 23:37:36 CST 2023, time=2023-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1264405, encodeId=f7f412644054b, content=<a href='/topic/show?id=daf1100226fb' target=_blank style='color:#2F92EE;'>#预测因素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100226, encryptionId=daf1100226fb, topicName=预测因素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a57b78, createdName=朱睿睿, createdTime=Fri Jun 03 02:37:36 CST 2022, time=2022-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1529996, encodeId=e4bc15299965e, content=<a href='/topic/show?id=bcc5306146d' target=_blank style='color:#2F92EE;'>#再入院率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30614, encryptionId=bcc5306146d, topicName=再入院率)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6a1e11986162, createdName=yzh403, createdTime=Fri Jun 03 02:37:36 CST 2022, time=2022-06-03, status=1, ipAttribution=)]
    2023-03-04 xjy02
  3. [GetPortalCommentsPageByObjectIdResponse(id=1939379, encodeId=9c0519393e9f4, content=<a href='/topic/show?id=1c292818fd' target=_blank style='color:#2F92EE;'>#ASC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2818, encryptionId=1c292818fd, topicName=ASC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Sun Aug 14 16:37:36 CST 2022, time=2022-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1863672, encodeId=0aca18636e2cc, content=<a href='/topic/show?id=c0b68135561' target=_blank style='color:#2F92EE;'>#肝细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81355, encryptionId=c0b68135561, topicName=肝细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Sat Mar 04 22:37:36 CST 2023, time=2023-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1979340, encodeId=810219e934067, content=<a href='/topic/show?id=3b90e79787f' target=_blank style='color:#2F92EE;'>#细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77978, encryptionId=3b90e79787f, topicName=细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Wed Apr 12 23:37:36 CST 2023, time=2023-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1264405, encodeId=f7f412644054b, content=<a href='/topic/show?id=daf1100226fb' target=_blank style='color:#2F92EE;'>#预测因素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100226, encryptionId=daf1100226fb, topicName=预测因素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a57b78, createdName=朱睿睿, createdTime=Fri Jun 03 02:37:36 CST 2022, time=2022-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1529996, encodeId=e4bc15299965e, content=<a href='/topic/show?id=bcc5306146d' target=_blank style='color:#2F92EE;'>#再入院率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30614, encryptionId=bcc5306146d, topicName=再入院率)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6a1e11986162, createdName=yzh403, createdTime=Fri Jun 03 02:37:36 CST 2022, time=2022-06-03, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1939379, encodeId=9c0519393e9f4, content=<a href='/topic/show?id=1c292818fd' target=_blank style='color:#2F92EE;'>#ASC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2818, encryptionId=1c292818fd, topicName=ASC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Sun Aug 14 16:37:36 CST 2022, time=2022-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1863672, encodeId=0aca18636e2cc, content=<a href='/topic/show?id=c0b68135561' target=_blank style='color:#2F92EE;'>#肝细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81355, encryptionId=c0b68135561, topicName=肝细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Sat Mar 04 22:37:36 CST 2023, time=2023-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1979340, encodeId=810219e934067, content=<a href='/topic/show?id=3b90e79787f' target=_blank style='color:#2F92EE;'>#细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77978, encryptionId=3b90e79787f, topicName=细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Wed Apr 12 23:37:36 CST 2023, time=2023-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1264405, encodeId=f7f412644054b, content=<a href='/topic/show?id=daf1100226fb' target=_blank style='color:#2F92EE;'>#预测因素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100226, encryptionId=daf1100226fb, topicName=预测因素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a57b78, createdName=朱睿睿, createdTime=Fri Jun 03 02:37:36 CST 2022, time=2022-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1529996, encodeId=e4bc15299965e, content=<a href='/topic/show?id=bcc5306146d' target=_blank style='color:#2F92EE;'>#再入院率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30614, encryptionId=bcc5306146d, topicName=再入院率)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6a1e11986162, createdName=yzh403, createdTime=Fri Jun 03 02:37:36 CST 2022, time=2022-06-03, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1939379, encodeId=9c0519393e9f4, content=<a href='/topic/show?id=1c292818fd' target=_blank style='color:#2F92EE;'>#ASC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2818, encryptionId=1c292818fd, topicName=ASC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Sun Aug 14 16:37:36 CST 2022, time=2022-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1863672, encodeId=0aca18636e2cc, content=<a href='/topic/show?id=c0b68135561' target=_blank style='color:#2F92EE;'>#肝细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81355, encryptionId=c0b68135561, topicName=肝细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Sat Mar 04 22:37:36 CST 2023, time=2023-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1979340, encodeId=810219e934067, content=<a href='/topic/show?id=3b90e79787f' target=_blank style='color:#2F92EE;'>#细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77978, encryptionId=3b90e79787f, topicName=细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Wed Apr 12 23:37:36 CST 2023, time=2023-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1264405, encodeId=f7f412644054b, content=<a href='/topic/show?id=daf1100226fb' target=_blank style='color:#2F92EE;'>#预测因素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100226, encryptionId=daf1100226fb, topicName=预测因素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a57b78, createdName=朱睿睿, createdTime=Fri Jun 03 02:37:36 CST 2022, time=2022-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1529996, encodeId=e4bc15299965e, content=<a href='/topic/show?id=bcc5306146d' target=_blank style='color:#2F92EE;'>#再入院率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30614, encryptionId=bcc5306146d, topicName=再入院率)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6a1e11986162, createdName=yzh403, createdTime=Fri Jun 03 02:37:36 CST 2022, time=2022-06-03, status=1, ipAttribution=)]

相关资讯

中药及活性成分可以发挥抗肿瘤活性,抑制肝癌

肝细胞癌 (HCC) 是全球主要的致死性肿瘤之一,其治疗仍然是一项巨大的医学挑战。手术和化学疗法是目前HCC患者的标准治疗方法,但预后仍然不佳。最近,中医药(TCM)被广泛应用于有效治疗HCC。

Clin Cancer Res:派姆单抗单药治疗初治晚期肝细胞癌

派姆单抗治疗可为初治晚期肝细胞癌患者提供持久的抗肿瘤活性、可期的总生存期

Clin Cancer Res:甲胎蛋白可作为肝细胞癌采用Atezolizuma+贝伐单抗治疗的预后生物标志物

治疗第6周时的AFP反应可作为受Atezolizuma+贝伐单抗治疗的肝细胞癌患者预后的替代生物标志物

CGH:恶病质在肝细胞癌患者中普遍存在并与更差的预后相关

肝细胞癌是原发性肝癌中的一种,原发性肝癌主要包括肝细胞性肝癌、胆管细胞性肝癌和混合性肝癌。

European Radiology:热消融在肝细胞癌治疗中的价值

本研究发现,TA对原发性和复发性HCC都是一种有效的治疗方式。虽然许多患者在随访过程中出现复发,但本研究证明,大多数患者可以通过重复TA进行治疗以缓解病情。

J Hepatol:新型的儿童肝癌分子亚型已被科学家识别到!

本文分析结果表明,携带肝细胞癌特征的儿童或许会得益于不同于肝母细胞癌和肝细胞癌患者治疗指南的治疗策略。