Neurobiology of Aging:中年肥胖使民众大脑老化速度加快10年

2016-08-05 MedSci MedSci原创

发表在Neurobiology of Aging的新近研究指出,与同年龄段正常体重的民众相比,肥胖或超重的面化工大脑白质体积减少。剑桥大学精神病学系的Paul Fletcher指出,白质减少的体积相当于大脑衰老十年左右。 世卫组织指出,自1980年以来全球肥胖人数已经翻了一倍多,仅在美国,就有超过1/3的成年人处于肥胖状态。 众所周知,肥胖可以增加民众出现许多健康问题包括心血管疾病、2型糖尿病和某

发表在Neurobiology of Aging的新近研究指出,与同年龄段正常体重的民众相比,肥胖或超重的民众大脑白质体积减少。

剑桥大学精神病学系的Paul Fletcher指出,白质减少的体积相当于大脑衰老十年左右。

世卫组织指出,自1980年以来全球肥胖人数已经翻了一倍多,仅在美国,就有超过1/3的成年人处于肥胖状态。 

众所周知,肥胖可以增加民众出现许多健康问题包括心血管疾病、2型糖尿病和某些癌症的风险。越来越多的研究人员发现,超重或肥胖可能对大脑也有负面影响。一些研究表明,肥胖可以加快大脑萎缩的速度,降低民众认知能力。

Fletcher教授指出,当今我们生活的社会老龄化速度加快,肥胖的民众人数越来越多,我们需要将二者联系起来以评估二者是否存在某种关联。为了进行深入研究,研究人员进行了一项横断面研究,招募了473名年龄范围为20-87岁且认知能力正常的民众参与研究。

参与者依据BMI将研究人员分为三组:正常组有246人(BMI:18.5-25),超重组有150人(BMI:25-30),肥胖组有77人(BMI>30)。此外,研究人员使用MRI测量参与者的大脑灰质和白纸体积。

研究人员发现,相比正常组而言,肥胖组和超重组民众白质体积显著减少,但民众的认知能力无明显差异。然后研究人员探究白质体积与年龄和体重之间的关系,他们发现肥胖和超重对中年人的大脑影响最大。

相比体重正常或偏瘦的中年人而言,肥胖或超重的中年人的大脑要衰老将近十岁,举例而言,一位50岁的肥胖成人实际上拥有60岁的大脑。

研究人员表示仍需进行更近一步的研究以探究减肥是否能规避这种风险,也要继续探究是中年肥胖导致大脑白质体积减少还是大脑白质体积减少导致民众肥胖。

原始出处:

[1] Brain aging accelerated by 10 years with midlife overweight obesity.MNT.2016 August 4.

[2] Lisa Ronan, et al. Obesity associated with increased brain-age from mid-life.Neurobiology of Aging.2016 July 27.

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    2017-04-18 sunylz
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    2016-10-09 ylzr123

    好文,从这里学习了好多新知识,新信息。赞了!

    0

  4. 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likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sat Sep 03 07:57:00 CST 2016, time=2016-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=101383, encodeId=57641013837c, content=继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Sat Aug 20 13:36:00 CST 2016, time=2016-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=101384, encodeId=c14d10138484, content=继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Sat Aug 20 13:36:00 CST 2016, time=2016-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1387994, encodeId=614d138e994fe, content=<a href='/topic/show?id=18b3800914e' target=_blank style='color:#2F92EE;'>#老化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80091, encryptionId=18b3800914e, topicName=老化)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/4v5DMqK7WnzoBdibNsryQ8OEM5gFSdRH9j3HNCKPfKXlObInweOSHdQPATeTicYp7nvg3bsgicjLgRkdlhrpry21w/132, createdBy=6bf82500013, createdName=ms5822920152752585, createdTime=Sun Aug 07 11:07:00 CST 2016, time=2016-08-07, status=1, ipAttribution=)]
    2016-09-15 ylzr123

    赞一个!好文章拜读了,认真学习了。

    0

  5. 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likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sat Sep 03 07:57:00 CST 2016, time=2016-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=101383, encodeId=57641013837c, content=继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Sat Aug 20 13:36:00 CST 2016, time=2016-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=101384, encodeId=c14d10138484, content=继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Sat Aug 20 13:36:00 CST 2016, time=2016-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1387994, encodeId=614d138e994fe, content=<a href='/topic/show?id=18b3800914e' target=_blank style='color:#2F92EE;'>#老化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80091, encryptionId=18b3800914e, topicName=老化)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/4v5DMqK7WnzoBdibNsryQ8OEM5gFSdRH9j3HNCKPfKXlObInweOSHdQPATeTicYp7nvg3bsgicjLgRkdlhrpry21w/132, createdBy=6bf82500013, createdName=ms5822920152752585, createdTime=Sun Aug 07 11:07:00 CST 2016, time=2016-08-07, status=1, ipAttribution=)]
    2016-09-09 1e10c84am36(暂无匿称)

    赞!好文章,拜读,深入学习。

    0

  6. 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likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sat Sep 03 07:57:00 CST 2016, time=2016-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=101383, encodeId=57641013837c, content=继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Sat Aug 20 13:36:00 CST 2016, time=2016-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=101384, encodeId=c14d10138484, content=继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Sat Aug 20 13:36:00 CST 2016, time=2016-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1387994, encodeId=614d138e994fe, content=<a href='/topic/show?id=18b3800914e' target=_blank style='color:#2F92EE;'>#老化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80091, encryptionId=18b3800914e, topicName=老化)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/4v5DMqK7WnzoBdibNsryQ8OEM5gFSdRH9j3HNCKPfKXlObInweOSHdQPATeTicYp7nvg3bsgicjLgRkdlhrpry21w/132, createdBy=6bf82500013, createdName=ms5822920152752585, createdTime=Sun Aug 07 11:07:00 CST 2016, time=2016-08-07, status=1, ipAttribution=)]
    2016-09-03 李东泽

    很好,不错,以后会多学习

    0

  7. 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likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sat Sep 03 07:57:00 CST 2016, time=2016-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=101383, encodeId=57641013837c, content=继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Sat Aug 20 13:36:00 CST 2016, time=2016-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=101384, encodeId=c14d10138484, content=继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Sat Aug 20 13:36:00 CST 2016, time=2016-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1387994, encodeId=614d138e994fe, content=<a href='/topic/show?id=18b3800914e' target=_blank style='color:#2F92EE;'>#老化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80091, encryptionId=18b3800914e, topicName=老化)], attachment=null, authenticateStatus=null, 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    2016-08-20 doctorJiangchao

    继续学习

    0

  8. 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    2016-08-20 doctorJiangchao

    继续关注

    0

  9. 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