多发性骨髓瘤肾损伤诊治专家共识

2017-11-20 多发性骨髓瘤肾损伤诊治专家共识协作组 中华内科杂志,2017,56(11): 871-875.

多发性骨髓瘤(MM)是骨髓中浆细胞系异常增生的恶性疾病,其能产生异常的单克隆免疫球蛋白,引起骨骼破坏、贫血、肾功能损害和免疫功能异常。MM占所有肿瘤的1%,在血液系统肿瘤中占第二位,诊断时中位年龄约70岁,发病率与人种相关,黑人发病率最高,亚洲人群较低。随着更新、更有效治疗方案的应用,MM的5年生存率已由1975年的25%提高至2003年的34%。 肾脏受累常见,根据肾损伤定义的不同,MM

中文标题:

多发性骨髓瘤肾损伤诊治专家共识

发布日期:

2017-11-20

简要介绍:

多发性骨髓瘤(MM)是骨髓中浆细胞系异常增生的恶性疾病,其能产生异常的单克隆免疫球蛋白,引起骨骼破坏、贫血、肾功能损害和免疫功能异常。MM占所有肿瘤的1%,在血液系统肿瘤中占第二位,诊断时中位年龄约70岁,发病率与人种相关,黑人发病率最高,亚洲人群较低。随着更新、更有效治疗方案的应用,MM的5年生存率已由1975年的25%提高至2003年的34%。

肾脏受累常见,根据肾损伤定义的不同,MM患者初诊或在病程的不同时期,发生肾损伤的比例为20%~50%,其中约半数肾功能可完全逆转,而其余可能演化为不同程度的肾功能不全,约2%~12%MM患者需要肾脏替代治疗。虽然目前国内外已有多个MM的诊疗指南,但国内尚缺乏规范的、系统的MM肾损伤的诊断与治疗方案。近年来国际上陆续发表、更新的MM指南中,以国际骨髓瘤工作组(IMWG)[2]和英国血液病学会标准委员会指定的指南/推荐较多涉及MM肾损伤的内容,本协作组在借鉴上述指南并参考美国国家综合癌症网络(NCCN) 的骨髓瘤诊疗指南的基础上,结合国内临床实践,制定了本共识。

 

拓展指南:多发性骨髓瘤相关指南:

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    2021-04-25 周美子

    学习了

    0

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    2018-01-07 lingxiao

    0

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    2018-01-07 lingxiao

    学习了

    0

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    2017-11-24 jennyli5986

    学习了

    0

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    2017-11-23 惠映实验室

    学习了.谢谢.

    0