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Novel Porphyrinic Covalent Organic Polymer with Polarity-Switchable Dual Wavelength for Accurate and Sensitive Photoelectrochemical Sensing

期刊: ANALYTICAL CHEMISTRY, 2023; 95 (37)

Herein, we synthesized a novel porphyrinic covalent organic polymer (TPAPP-PTCA PCOP) for constructing a polarity-switchable dual-wavelength photoelec......

Reaction-Activated Disassembly of the NIR-II Probe Enables Fast Detection and Ratiometric Photoacoustic Imaging of Glutathione In Vivo

期刊: ANALYTICAL CHEMISTRY, 2023; 95 (37)

Glutathione (GSH), the most abundant nonprotein biothiol, is a significant endogenous molecule that plays a key role in redox equilibrium in vivo and ......

Hairpin Switches-Based Isothermal Transcription Amplification for Simple, Sensitivity Detection of MicroRNA

期刊: ANALYTICAL CHEMISTRY, 2023; 95 (37)

The ability to simply, selectively, and sensitively detect low numbers of miRNAs in clinical samples is highly valuable but remains a challenge. In th......

Solution and Gas-Phase Stability of DNA Junctions from Temperature-Controlled Electrospray Ionization and Surface-Induced Dissociation

期刊: ANALYTICAL CHEMISTRY, 2023; 95 (38)

DNA three-way junction (TWJ) structures transiently form during key cellular processes such as transcription, replication, and DNA repair. Despite the......

Integrated Microfluidic Chip for Rapid Antimicrobial Susceptibility Testing Directly from Positive Blood Cultures

期刊: ANALYTICAL CHEMISTRY, 2023; 95 (38)

Rapid and accurate antimicrobial prescriptions are critical for bloodstream infection (BSI) patients, as they can guide drug use and decrease mortalit......

Advancing Intact Protein Quantitation with Updated Deconvolution Routines

期刊: ANALYTICAL CHEMISTRY, 2023; 95 (40)

Analysis of intact proteins by mass spectrometry enables direct quantitation of the specific proteoforms present in a sample and is an increasingly im......

Using Multidimensional Separations to Distinguish Isomeric Amino Acid-Bile Acid Conjugates and Assess Their Presence and Perturbations in Model Systems

期刊: ANALYTICAL CHEMISTRY, 2023; 95 (41)

Bile acids play key roles in nutrient uptake, inflammation, signaling, and microbiome composition. While previous bile acid analyses have primarily fo......

Low-Background CRISPR/Cas12a Sensors for Versatile Live-Cell Biosensing

期刊: ANALYTICAL CHEMISTRY, 2023; 95 (42)

The trans-cleavage activity of CRISPR/Cas12a has been widely used in biosensing. However, many CRISPR/Cas12a-based biosensors, especially those that w......

Mobile Affinity Selection Chromatography Analysis of Therapeutic Monoclonal Antibodies

期刊: ANALYTICAL CHEMISTRY, 2023; 95 (44)

Federal regulatory agencies require continuous verification of recombinant therapeutic monoclonal antibody (mAb) quality that is commonly achieved in ......

NIR Light-Activated Mitochondrial RNA Cross-Linking Strategy for H2S Monitoring and Prolonged Colorectal Tumor Imaging

期刊: ANALYTICAL CHEMISTRY, 2023; 95 (46)

Molecular diffusion and leakage impede the long-term retention of probes/drugs and may cause potential adverse effects in theranostic fields. Spatiote......

Recognition of Oligonucleotide C by Polydopamine-Coated Solid-State Nanopores

期刊: ANALYTICAL CHEMISTRY, 2023; 95 (47)

Selective recognition of short oligonucleotides at the single-molecule level is particularly important for early disease detection and treatment. In t......

Relaxation-Assisted Magnetization Transfer Phenomena for a Sensitivity-Enhanced 2D NMR

期刊: ANALYTICAL CHEMISTRY, 2023; 95 (49)

2D NOESY and TOCSY play central roles in contemporary NMR. We have recently discussed how solvent-driven exchanges can significantly enhance the sensi......

Dual Self-Amplification Homogeneous Electrochemiluminescence Biosensor for Terminal Deoxynucleotidyl Transferase Activity Based on Controlling the Surface Morphology and Charge of Reporter Nanoparticles

期刊: ANALYTICAL CHEMISTRY, 2023; 95 (50)

Terminal deoxynucleotidyl transferase (TdT) is upregulated in several types of leukemia and is considered a disease biomarker and a potential therapeu......

Phage Tail Fiber Protein as a Specific Probe for Recognition of Shiga Toxin-Producing Escherichia coli O91, O103, and O111

期刊: ANALYTICAL CHEMISTRY, 2023; 95 (50)

The ability to quickly identify specific serotypes of Shiga toxin-producing Escherichia coli (STEC) could facilitate the monitoring and control of STE......

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