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Methylglyoxal-mediated Gpd1 activation restores the mitochondrial defects in a yeast model of mitochondrial DNA depletion syndrome

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2023; 1867 (5)

Human MPV17, an evolutionarily conserved mitochondrial inner-membrane channel protein, accounts for the tissue-specific mitochondrial DNA depletion sy......

Suppression of endoplasmic reticulum stress reverses hindlimb unloading-induced hepatic cellular processes in mice

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2023; 1867 (9)

Background: The Hindlimb unloaded mouse, an animal model of simulated microgravity demonstrates significant metabolic and hepatic derangements. Howeve......

The D647N mutation of FGFR1 induces ligand-independent receptor activation

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2023; 1867 (12)

The activation loop (A-loop) of kinases, a key regulatory region, is recurrently mutated in several kinase proteins in cancer resulting in dysregulate......

Bioinformatics, thermodynamics, and mechanical resistance of the FtsZ-ZipA complex of Escherichia coli supports a highly dynamic protein interaction in the divisome

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2023; 1867 (12)

In most microorganisms, cell division is guided by the divisome, a multiprotein complex that assembles at the equator of the cell and is responsible f......

Gold nanoparticles reduce tubule-interstitial injury and proteinuria in a murine model of subclinical acute kidney injury

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2023; 1867 (4)

Subclinical acute kidney injury (subAKI) is characterized by tubule-interstitial injury without significant changes in glomerular function. SubAKI is ......

Variations in the enzymatic activity of S1-type nucleases results from differences in their active site structures

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2023; 1867 (10)

Background: S1-like nucleases are widespread enzymes commonly used in biotechnology and molecular biology. Although it is commonly believed that they ......

Splice variants of protein disulfide isomerase-identification, distribution and functional characterization in the rat

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2023; 1867 (2)

Background: Protein Disulfide Isomerase (PDI) enzyme is an emerging therapeutic target in oncology and hematology. Although PDI reductase activity has......

Can the molecules carried by extracellular vesicles help to diagnose pancreatic cancer early?

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2023; 1867 (9)

Background: Pancreatic cancer is a deadly malignancy mainly because of its asymptomatic onset which prevents the implementation of the primary tumour'......

Metalloglycobiology: The power of metals in regulating glycosylation

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2023; 1867 (9)

The remarkable structural diversity of glycans that is exposed at the cell surface and generated along the secretory pathway is tightly regulated by s......

Differential processing of CRISPR RNA by LinCas5c and LinCas6 of Leptospira

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2023; 1867 (12)

Leptospira interrogans serovar Copenhageni's genome harbors two CRISPR-Cas systems belonging to subtypes I-B and I-C. However, in L. interrogans, the ......

Disallowed spots in protein structures

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2023; 1867 (12)

Ramachandran (phi, psi) steric map was introduced in 1963 to describe available conformation space for protein structures. Subsequently, residues were......

A characteristic N-glycopeptide signature associated with diabetic cognitive impairment identified in a longitudinal cohort study

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2023; 1867 (4)

Background: Identifying a biomarker for the decline in cognitive function in patients with diabetes is important. Therefore, we aimed to identify the ......

Narirutin downregulates lipoxygenase-5 expression and induces G0/G1 arrest in triple-negative breast carcinoma cells

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2023; 1867 (6)

Background: Triple-negative breast cancer (TNBC) accounts for 20% of breast cancer that does not express HER2, progesterone and estrogen receptors. It......

Towards the CSNK2 phosphoproteome - With lessons from the COVID-19 pandemic to revealing the secrets of CSNK2 and its promise as a therapeutic target

期刊: BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2023; 1867 (10)

Dramatic advances in phosphoproteomics and the development of a selective chemical probe have presented new opportunities for revealing the cellular l......

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