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SLCO4A1-AS1 promotes colorectal tumourigenesis by regulating Cdk2/c-Myc signalling

期刊: JOURNAL OF BIOMEDICAL SCIENCE, 2022; 29 (1)

Background SLCO4A1-AS1 was found to be upregulated in several cancer types, including colorectal cancer (CRC). However, the detailed roles of SLCO4A1-......

JIF:7.628

Preclinical validation and phase I trial of 4-hydroxysalicylanilide, targeting ribonucleotide reductase mediated dNTP synthesis in multiple myeloma

期刊: JOURNAL OF BIOMEDICAL SCIENCE, 2022; 29 (1)

Background Aberrant DNA repair pathways contribute to malignant transformation or disease progression and the acquisition of drug resistance in multip......

JIF:7.628

Functional and structural characteristics of HLA-B*13:01-mediated specific T cells reaction in dapsone-induced drug hypersensitivity

期刊: JOURNAL OF BIOMEDICAL SCIENCE, 2022; 29 (1)

Background: Severe cutaneous adverse drug reactions (SCARs) are a group of serious clinical conditions caused by immune reaction to certain drugs. The......

JIF:7.628

Mitochondrial oxidative stress in the tumor microenvironment and cancer immunoescape: foe or friend?

期刊: JOURNAL OF BIOMEDICAL SCIENCE, 2022; 29 (1)

The major concept of oxidative stress is an excess elevated level of reactive oxygen species (ROS) which are generated from vigorous metabolism and co......

JIF:7.628

Post-translational modifications on the retinoblastoma protein

期刊: JOURNAL OF BIOMEDICAL SCIENCE, 2022; 29 (1)

The retinoblastoma protein (pRb) functions as a cell cycle regulator controlling G1 to S phase transition and plays critical roles in tumour suppressi......

JIF:7.628

The pathogenic effects of particulate matter on neurodegeneration: a review

期刊: JOURNAL OF BIOMEDICAL SCIENCE, 2022; 29 (1)

The increasing amount of particulate matter (PM) in the ambient air is a pressing public health issue globally. Epidemiological studies involving data......

JIF:7.628

The effects of SARS-CoV-2 infection on modulating innate immunity and strategies of combating inflammatory response for COVID-19 therapy

期刊: JOURNAL OF BIOMEDICAL SCIENCE, 2022; 29 (1)

The global pandemic of COVID-19 has caused huge causality and unquantifiable loss of social wealth. The innate immune response is the first line of de......

JIF:7.628

Cysteine-rich protein 2 deficiency attenuates angiotensin II-induced abdominal aortic aneurysm formation in mice

期刊: JOURNAL OF BIOMEDICAL SCIENCE, 2022; 29 (1)

Background Abdominal aortic aneurysm (AAA) is a relatively common and often fatal condition. A major histopathological hallmark of AAA is the severe d......

JIF:7.628

DYRK1A reinforces epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma via cooperatively activating STAT3 and SMAD

期刊: JOURNAL OF BIOMEDICAL SCIENCE, 2022; 29 (1)

Background Hepatocellular carcinoma (HCC) accounts for the majority of liver cancer cases, while metastasis is considered the leading cause of HCC-rel......

JIF:7.628

Application of engineered extracellular vesicles for targeted tumor therapy

期刊: JOURNAL OF BIOMEDICAL SCIENCE, 2022; 29 (1)

All cells, including prokaryotes and eukaryotes, could release extracellular vesicles (EVs). EVs contain many cellular components, including RNA, and ......

JIF:7.628

Moonlighting glyceraldehyde-3-phosphate dehydrogenase (GAPDH) protein of Lactobacillus gasseri attenuates allergic asthma via immunometabolic change in macrophages

期刊: JOURNAL OF BIOMEDICAL SCIENCE, 2022; 29 (1)

Background The extra-intestinal effects of probiotics for preventing allergic diseases are well known. However, the probiotic components that interact......

JIF:7.628

Periostin promotes ovarian cancer metastasis by enhancing M2 macrophages and cancer-associated fibroblasts via integrin-mediated NF-kappa B and TGF-beta 2 signaling

期刊: JOURNAL OF BIOMEDICAL SCIENCE, 2022; 29 (1)

Background: Ovarian cancer has the highest mortality among gynecological cancers due to late diagnosis and lack of effective targeted therapy. Althoug......

JIF:7.628

Induction of high affinity monoclonal antibodies against SARS-CoV-2 variant infection using a DNA prime-protein boost strategy

期刊: JOURNAL OF BIOMEDICAL SCIENCE, 2022; 29 (1)

Background Calls for the coronavirus to be treated as an endemic illness, such as the flu, are increasing. After achieving high coverage of COVID-19 v......

JIF:7.628

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