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Edaravone attenuates H2O2 or glutamate-induced toxicity in hippocampal neurons and improves AlCl3/D-galactose induced cognitive impairment in mice

期刊: NEUROTOXICOLOGY, 2021; 85 ()

Edaravone (Eda) is a free radical scavenger used in clinical trials for the treatment of ischemic stroke and amyotrophic lateral sclerosis. However, h......

Vitamin A supplementation ameliorates motor incoordination via modulating ROR alpha in the cerebellum in a valproic acid-treated rat autism model with vitamin A deficiency

期刊: NEUROTOXICOLOGY, 2021; 85 ()

Motor dysfunctions are common comorbidities among autism spectrum disorder (ASD) patients. Abnormal cerebellar development throughout critical periods......

Arsenic induces autophagy-dependent apoptosis via Akt inactivation and AMPK activation signaling pathways leading to neuronal cell death

期刊: NEUROTOXICOLOGY, 2021; 85 ()

Inorganic arsenic (As3+), a well-known worldwide industrial and environmental pollutant, has been linked to neurodegenerative disorders (NDs). Autopha......

Anti-inflammatory and neuroprotective effects of natural cordycepin in rotenone-induced PD models through inhibiting Drp1-mediated mitochondrial fission

期刊: NEUROTOXICOLOGY, 2021; 84 ()

Accumulating evidences suggest that inflammation-mediated neurons dysfunction participates in the initial and development of Parkinson's disease (PD),......

PI3K/AKT pathway mediates the antidepressant- and anxiolytic-like roles of hydrogen sulfide in streptozotocin-induced diabetic rats via promoting hippocampal neurogenesis

期刊: NEUROTOXICOLOGY, 2021; 85 ()

We have previously demonstrated that hydrogen sulfide (H2S), the third endogenous gasotransmitter, ameliorates the depression- and anxiety-like behavi......

Mechanisms of oxidative stress in methylmercury-induced neurodevelopmental toxicity

期刊: NEUROTOXICOLOGY, 2021; 85 ()

Methylmercury (MeHg) is a long-lasting organic environmental pollutant that poses a great threat to human health. Ingestion of seafood containing MeHg......

Effect of arsenic-containing hydrocarbon on the long-term potentiation at Schaffer Collateral-CA1 synapses from infantile male rat

期刊: NEUROTOXICOLOGY, 2021; 84 ()

Arsenic-containing hydrocarbons (AsHCs) are common constituents of marine organisms and have potential toxicity to human health. This work is to study......

Taurine improves neuron injuries and cognitive impairment in a mouse Parkinson?s disease model through inhibition of microglial activation

期刊: NEUROTOXICOLOGY, 2021; 83 ()

Clinical and experimental findings support the view that activation of hippocampus microglia through NADPH oxidase contributes to cognitive impairment......

Postweaning exposure to lanthanum alters neurological behavior during early adulthood in rats

期刊: NEUROTOXICOLOGY, 2021; 83 ()

Lanthanum is a rare-earth element that has been used in various fields including medicine, agriculture and industry. Previously, in utero lanthanum ex......

Astrocyte-derived exosomes carry microRNA-17-5p to protect neonatal rats from hypoxic-ischemic brain damage via inhibiting BNIP-2 expression

期刊: NEUROTOXICOLOGY, 2021; 83 ()

Exosomes play critical roles in neurogenesis. This study aims to explore the mechanism of astrocyte-derived exosomes in neonatal rats with hypoxic-isc......

Impact of Lead Exposure on Thyroid Status and IQ Performance among School-age Children Living Nearby a Lead-Zinc Mine in China

期刊: NEUROTOXICOLOGY, 2021; 82 ()

Background: Lead exposure is one of the most concerning public health problems worldwide, particularly among children. Yet the impact of chronic lead ......

Association of arsenic exposure and cognitive impairment: A population-based cross-sectional study in China

期刊: NEUROTOXICOLOGY, 2021; 82 ()

Background: The influence of chronic arsenic exposure on cognitive impairment has been explored broadly by previous studies. However, most of them foc......

Influence of postnatal polycyclic aromatic hydrocarbon exposure on the neurodevelopment of toddlers at the age of 12 months

期刊: NEUROTOXICOLOGY, 2021; 82 ()

Objectives: To investigate the possible influence of polycyclic aromatic hydrocarbons (PAHs) exposure on neurodevelopment of toddlers at the age of 12......

General anesthesia activates the mitochondrial unfolded protein response and induces age-dependent, long-lasting changes in mitochondrial function in the developing brain

期刊: NEUROTOXICOLOGY, 2021; 82 ()

General anesthesia induces changes in dendritic spine number and synaptic transmission in developing mice. These changes are rather disturbing, as sim......

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