Poldip2 is an oxygen-sensitive protein that controls PDH and alpha KGDH lipoylation and activation to support metabolic adaptation in hypoxia and cancer

Paredes, F; Sheldon, K; Lassegue, B; Williams, HC; Faidley, EA; Benavides, GA; Torres, G; Sanhueza-Olivares, F; Yeligar, SM; Griendling, KK; Darley-Usmar, V; San Martin, A

San Martin, A (reprint author), Emory Univ, Dept Med, Div Cardiol, Atlanta, GA 30322 USA.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018; 115 (8): 1789

Abstract

Although the addition of the prosthetic group lipoate is essential to the activity of critical mitochondrial catabolic enzymes, its regulation is unkn......

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