Iterative optimization yields Mcl-1-targeting stapled peptides with selective cytotoxicity to Mcl-1-dependent cancer cells

Araghi, RR; Bird, GH; Ryan, JA; Jenson, JM; Godes, M; Pritz, JR; Grant, RA; Letai, A; Walensky, LD; Keating, AE

Keating, AE (reprint author), MIT, Dept Biol, 77 Massachusetts Ave, Cambridge, MA 02139 USA.; Walensky, LD (reprint author), Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02215 USA.; Walensky, LD (reprint author), Dana Farber Canc Inst, Linde Progr

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018; 115 (5): E886

Abstract

Bcl-2 family proteins regulate apoptosis, and aberrant interactions of overexpressed antiapoptotic family members such as Mcl-1 promote cell transform......

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