Antileukemic activity and mechanism of action of the novel PI3K and histone deacetylase dual inhibitor CUDC-907 in acute myeloid leukemia

Li, XY; Su, YW; Madlambayan, G; Edwards, H; Polin, L; Kushner, J; Dzinic, SH; White, K; Ma, J; Knight, T; Wang, G; Wang, Y; Yang, J; Taub, JW; Lin, H; Ge, YB

Ge, YB (reprint author), Wayne State Univ, Sch Med, Dept Oncol, Detroit, MI 48202 USA.; Ge, YB (reprint author), Wayne State Univ, Sch Med, Barbara Ann Karmanos Canc Inst, Mol Therapeut Program, Detroit, MI 48202 USA.; Ge, YB (reprint author), Wayne State

HAEMATOLOGICA, 2019; 104 (11): 2225

Abstract

Induction therapy for patients with acute myeloid leukemia (AML) has remained largely unchanged for over 40 years, while overall survival rates remain......

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