Bcl-2/Bcl-xL inhibitor navitoclax increases the antitumor effect of Chk1 inhibitor prexasertib by inducing apoptosis in pancreatic cancer cells via inhibition of Bcl-xL but not Bcl-2

Morimoto, Y; Takada, K; Takeuchi, O; Watanabe, K; Hirohara, M; Hamamoto, T; Masuda, Y

Morimoto, Y (corresponding author), Showa Pharmaceut Univ, Ctr Educ & Res Clin Pharm, 3-3165 Higashi Tamagawagakuen, Machida, Tokyo 1948543, Japan.

MOLECULAR AND CELLULAR BIOCHEMISTRY, 2020; 472 (1-2): 187

Abstract

In our previous study, we showed that prexasertib, a checkpoint kinase 1 (Chk1) inhibitor, enhances the effects of standard drugs for pancreatic cance......

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