The RUNX1-ETO target gene RASSF2 suppresses t(8;21) AML development and regulates Rac GTPase signaling

Stoner, SA; Liu, KTH; Andrews, ET; Liu, MD; Arimoto, KI; Yan, M; Davis, AG; Weng, S; Dow, M; Xian, S; DeKelver, RC; Carter, H; Zhang, DE

Zhang, DE (corresponding author), Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA.; Zhang, DE (corresponding author), Univ Calif San Diego, Biomed Sci Grad Program, La Jolla, CA 92093 USA.; Zhang, DE (corresponding author), Univ Calif San Diego, Div Biol Sci, La Jolla, CA 92093 USA.; Zhang, DE (corresponding author), Univ Calif San Diego, Dept Pathol, La Jolla, CA 92093 USA.

BLOOD CANCER JOURNAL, 2020; 10 (2):

Abstract

Large-scale chromosomal translocations are frequent oncogenic drivers in acute myeloid leukemia (AML). These translocations often occur in critical tr......

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