Differential impact of BTK active site inhibitors on the conformational state of full-length BTK

Joseph, RE; Amatya, N; Fulton, DB; Engen, JR; Wales, TE; Andreotti, A

Andreotti, A (corresponding author), Iowa State Univ, Roy J Carver Dept Biochem Biophys & Mol Biol, Ames, IA 50011 USA.; Wales, TE (corresponding author), Northeastern Univ, Dept Chem & Chem Biol, Boston, MA 02115 USA.

ELIFE, 2020; 9 ():

Abstract

Bruton's tyrosine kinase (BTK) is targeted in the treatment of B-cell disorders including leukemias and lymphomas. Currently approved BTK inhibitors, ......

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