Methylation of hypoxia-inducible factor (HIF)-1 alpha by G9a/GLP inhibits HIF-1 transcriptional activity and cell migration

Bao, L; Chen, Y; Lai, HT; Wu, SY; Wang, JE; Hatanpaa, KJ; Raisanen, JM; Fontenot, M; Lega, B; Chiang, CM; Semenza, GL; Wang, YF; Luo, WB

Wang, YF; Luo, WB (reprint author), UT Southwestern Med Ctr, Dept Pathol, Dallas, TX 75390 USA.; Luo, WB (reprint author), UT Southwestern Med Ctr, Dept Pharmacol, Dallas, TX 75390 USA.; Wang, YF (reprint author), UT Southwestern Med Ctr, Dept Neurol & Ne

NUCLEIC ACIDS RESEARCH, 2018; 46 (13): 6576

Abstract

Hypoxia-inducible factor 1 (HIF-1) is a master transcriptional regulator in response to hypoxia and its transcriptional activity is crucial for cancer......

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