Effect of Plasma Protein Binding on the Anti-Hepatitis B Virus Activity and Pharmacokinetic Properties of NVR 3-778

Helsen, N; Vervoort, T; Vandenbossche, J; Len, O; Monshouwer, M; Pauwels, F; Snoeys, J

Snoeys, J (reprint author), Janssen Res & Dev, Beerse, Belgium.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2018; 62 (11):

Abstract

High plasma protein binding (PPB) levels not only affect drug-target engagement but can also impact exposure of hepatocytes to antivirals and thereby ......

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