Synthesis and Evaluation of Dapagliflozin Ester Prodrugs with Improved Hygroscopicity and Thermal Stability

Sung, SY; Chae, YN; Lee, DY; Kim, KM; Kim, EJ; Han, JH; Kim, W; Yoon, SH

Yoon, SH (corresponding author), Ajou Univ, Dept Mol Sci & Technol, Suwon 16499, South Korea.

LETTERS IN DRUG DESIGN & DISCOVERY, 2020; 17 (11): 1409

Abstract

Background: Dapagliflozin, developed as an SGLT-2 inhibitor, has a low melting point and high hygroscopicity, which needs extreme care during pharmace......

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