期刊： LETTERS IN DRUG DESIGN & DISCOVERY, 2021; 18 (4)
Background: The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has attracted w......
期刊： LETTERS IN DRUG DESIGN & DISCOVERY, 2021; 18 (5)
Background: Abnormal deposition of amyloid beta (A beta) is considered the primary cause of neurocognitive disorders (NCDs). Inhibiting cytotoxicity i......
期刊： LETTERS IN DRUG DESIGN & DISCOVERY, 2021; 18 (5)
Background: Thrombolysis and endovascular thrombectomy are the two main therapeutic strategies for ischemic stroke in clinic. However, reperfusion inj......
期刊： LETTERS IN DRUG DESIGN & DISCOVERY, 2021; 18 (2)
Y Background: Oxadiazole fragment is one of the most prevalent structures in biochemicals, especially in the research of new pesticides. It is necessa......
期刊： LETTERS IN DRUG DESIGN & DISCOVERY, 2021; 18 (5)
Background: Spirocyclic indoline compounds widely exist in numerous natural products and synthetic molecules with significant biological activities. I......
期刊： LETTERS IN DRUG DESIGN & DISCOVERY, 2021; 18 (5)
Background: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a novel member of the genus betacoronavirus in the Coronaviridae family. I......
期刊： LETTERS IN DRUG DESIGN & DISCOVERY, 2021; 18 (4)
Background: Trypanosomiasis is a widespread zoonotic disease and the existing drugs are not enough to prevent and treat it. Objective: This study aime......
期刊： LETTERS IN DRUG DESIGN & DISCOVERY, 2021; 18 (1)
Background: The combination of two or more therapeutic drugs is an attractive approach to improve the treatment of experimental tumors. Leveraging nan......
期刊： LETTERS IN DRUG DESIGN & DISCOVERY, 2021; 18 (1)
Background: The appearance of antibiotic resistance caused by metallo-beta-lactamases (M beta Ls) is a global public health threat. Developing M beta ......
期刊： LETTERS IN DRUG DESIGN & DISCOVERY, 2020; 17 (3)
Background: Plant-derived natural compounds have a unique molecular structure and rich biological activity, hence, they are treated as important raw m......
期刊： LETTERS IN DRUG DESIGN & DISCOVERY, 2020; 17 (8)
Background: MDA-MB-231 is a Triple-Negative Breast Cancer (TNBC) cell line, which is resistant to tyrosine kinase inhibitors, such as lapatinib. Lapat......
期刊： LETTERS IN DRUG DESIGN & DISCOVERY, 2020; 17 (3)
UBackground: The bromodomain and extra-terminal proteins (BET), in particular BRD4, has recently emerged as a potential therapeutic target for the tre......
期刊： LETTERS IN DRUG DESIGN & DISCOVERY, 2020; 17 (3)
Background: Due to the extensive use of a single fungicide to control crop diseases, the increase of resistant individuals leads to control failures. ......
期刊： LETTERS IN DRUG DESIGN & DISCOVERY, 2020; 17 (3)
Background: Limonoids represent an important class of natural products which possess a broad range of biological activities. Albeit their enormous pot......
期刊： LETTERS IN DRUG DESIGN & DISCOVERY, 2020; 17 (1)
Background: Cancer incidence and mortality have been increasing and cancer is still the leading cause of death all over the world. Despite the enormou......
