Identification and optimization of novel 6-acylamino-2-aminoquinolines as potent Hsp90 C-terminal inhibitors

Jiang, F; Guo, AP; Xu, JC; Wang, HJ; Mo, XF; You, QD; Xu, XL

Xu, XL (reprint author), China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China.; Xu, XL (reprint author), China Pharmaceut Univ, Jiang Su Key Lab Drug Design & Optimizat, Nanjing 210009, Jiangsu, Peoples R China.; You, QD;

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017; 141 ( ): 1

Abstract

In order to discover novel Hsp90 inhibitors targeting the C-terminal ATP binding pocket, a novobiocin derivative based ROCS model was constructed for ......

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