Structure-based identification of a NEDD8-activating enzyme inhibitor via drug repurposing

Wu, KJ; Zhong, HJ; Li, GD; Liu, CF; Wang, HMD; Ma, DL; Leung, CH

Ma, DL (reprint author), Hong Kong Baptist Univ, Dept Chem, T1303, Hong Kong, Hong Kong, Peoples R China.; Leung, CH (reprint author), Univ Macau, Inst Chinese Med Sci, Taipa, Macau, Peoples R China.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018; 143 (): 1021

Abstract

NEDD8-activating enzyme (NAE) is an essential player of the NEDD8 conjugation pathway that regulates protein degradation. Meanwhile, drug repurposing ......

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